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ELICITATION, BIOCONVERSION AND QUANTIFICATION OF BERBERINE FROM CISSAMPELOS PARIERA CALLUS CULTURES
Cissampelos pariera, an important medicinal plant was subjected to elicitation and bioconversion of precursors for the formation of Berberine, an important medicinal component. In vitro cultures of Cissampelos pariera, was successfully established using stem and leaf explants. MS Media fortified with IAA (2 mg/l) alone and MS media enriched with IAA (2mg/l) showed profuse callusing from leaf and s...
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EVALUATION OF DIFFERENT SYNTHETIC AND NATURAL POLYMERS AS PROTECTIVE LAYER POLYMERS ON TOLTERODINE TARTRATE CONTROL RELEASE MUPS TABLETS
Evaluation of different natural and synthetic polymers as protective layer polymers in the manufacturing of control release multi-unit pellet tablets, Tolterodine Tartrate was selected as a model drug with aqueous ethylcellulose suspension is used as control release polymer. Tolterodine Tartrate is highly soluble BCS Class- I molecule, hence selected aqueous solution layering method for drug loadi...
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EXPERIMENTAL DESIGN APPROACH TO OPTIMIZATION OF THE NEW COMMERCIAL RP-HPLC DISCRIMINATION CONDITIONS FOR THE ESTIMATION OF PARACETAMOL AND ZALTAPROFEN IN PHARMACEUTICAL FORMULATION
A simple, rapid, RP-HPLC method developed for the simultaneous estimation of paracetamol and zaltaprofen in commercial pharmaceutical formulation by applying Derringer’s desirability function. The dependent variables such as Capacity factor of first peak, α value and retention time of tR3 as the responses with three important independent factors of organic phase composition, pH of mobile phase ...
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SYNERGISM BETWEEN CASSIA FISTULA AND FLUCONAZOLE; “A NEW APPROACH AGAINST CANDIDIASIS”
Natural products have great potential against microbes and can be used to overcome the problem of drug resistant pathogens. They are helpful in reducing the toxicity of existing antifungal compounds. This present in vitro study demonstrated the synergistic effectiveness of Cassia fistula (CF) leaves extracts and fluconazole (Flu) against isolated Flu resistant strains (FRSs) of Candida albicans (C...
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APPROPRIATE USE OF ANTIBIOTICS FOR THE MANAGEMENT OF SEPSIS IN NEONATES
Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolongation of hospital stay. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for timely diagnosis. Antibiotics are a very important group of drugs for the sick neonate and have undoubtedly played a role in their improved survival. But...
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AQUEOUS ROOT EXTRACT OF THE ANTIMALARIAL HERBAL CRYPTOLEPIS SANGUINOLENTA (LINDL.) SCHLTR DELAYS THE DEVELOPMENT OF PHYSICAL LANDMARKS AND SENSORIMOTOR SYSTEMS IN MICE
We demonstrated previously that the aqueous root extract of Cryptolepis sanguinolenta (cryptolepis), with cryptolepine as the major constituent adversely affect reproduction and foetal development in mice. However, very little is known on the effect of prenatal exposure of cryptolepis on the post-natal life of surviving animals. Using murine models, we report here, the effects of prenatal exposu...
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PHYTOCHEMICAL PHARMACOGNOSTICAL ANTIMICROBIAL AND CYTOTOXICITY STUDIES ON CANTHIUM COROMANDELICUM FRUIT
The medicinal plants are the key source in the life of human beings. The present study was aimed to evaluate the preliminary phytochemistry, pharmacognostical and antimicrobial activity of Canthium coromandelicum fruit. The fruit showed the presence of secondary metabolites like flavonoids, steroids, tannins, phenol, sterols, cardiac glycoside and saponin glycoside in various extracts. The pharmac...
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PRECLINICAL ACUTE AND REPEATED DOSE TOXICITY OF PUERARIA TUBEROSA (PTWE) ON CHARLES FOSTER RATS
Here we have carried out the acute and repeated dose toxicity study on tubers of Pueraria tuberosa water extract (PTWE). For acute toxicity study, rats were orally administered a single dose of 2000 and 5000 mg/kg body weight of PTWE. For repeated dose toxicity study on rats in one set, the different doses were given daily up to 28 days to make general observation and mortality rate. In another se...
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RADICAL SCAVENGING POTENTIAL OF CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)
The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the...
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DEVELOPMENT AND IN VITRO EVALUATION OF MICRONIZED SUSTAINED RELEASE MATRIX TABLET OF CARVEDILOL
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dis...
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