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PATHOPHYSIOLOGICAL STATUS OF SERUM ANTIOXIDANT, MACRO-MINERALS AND TRACE ELEMENTS IN PATIENTS WITH METABOLIC SYNDROME IN BANGLADESH
This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro - minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spe...
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CLINICOPATHOLOGICAL STUDY OF 115 CASES OF GLIOBLASTOMA MULTIFORME WITH SPECIAL REFERENCE TO GLIOSARCOMA
Background: Glioblastoma Multiforme is the commonest of all astrocytomas. It accounts for 12-15% of all intracranial neoplasm and 50-60% of all astrocytic tumors. Most common site of occurrence is cerebrum and age incidence is highest in fifth and sixth decade. Gliosarcoma constitutes 2% of all brain tumors, 5% of all astrocytomas and 8% of anaplastic astrocytomas. The cell of origin of sarcomatou...
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CONSUMER PROPERTIES OF TRANSDERMAL PATCHES AND THEIR USE IN MODERN PHARMACOTHERAPY
In today's hectic lifestyle, such dosage form as plaster, attracts more attention of scientists and gives new opportunities to use it in medicine. The purpose of our study was to investigate consumer properties of transdermal patches, hold the commodity analysis of the dosage form and determine the prospectiveness of their use in modern pharmacotherapy. Market review has been conducted. Analyzed t...
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LIPOSOMAL GEL AS OCULAR DELIVERY SYSTEM FOR DICLOFENAC SODIUM: IN- VITRO AND IN-VIVO STUDIES
The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area. Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7)...
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BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds...
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METABOLIC SYNDROME: PREVALENCE (IDF & NCEP-ATP III) IN UDHAMPUR, JAMMU CITY
Aim: To determine the prevalence of metabolic syndrome in Udhampur, J & K population according to two different criteria’s (IDF & NCEP-ATP III). Methods: A cross-sectional survey was conducted for the prevalence of metabolic syndrome among 210 participants. A pre-designed questionnaire was used to collect data, including demographic information; physical activity and biochemical paramete...
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TRANSMISSION OF HEPATOCURATIVE EFFECT OF SPILANTHES ACMELLA EXTRACT BASED GEL
Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes ac...
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AMELIORATION OF DIABETES BY SWIETENIA MAHAGONI IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Sweitenia mahagoni is a natural medicine used to treat various human ailments including diabetes. The present study is a comprehensive approach which targets more than one locus in the diabetic model to enumerate the anti-diabetic potential of Swietenia mahagoni as claimed by folklore. Oral administration of the aqueous extract of the leaf decreased the fasting blood glucose level (155.2±6.7) fro...
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ANKLE EDEMA FORMATION DURING TREATMENT WITH THE AMLODIPINE IN A TERTIARY CARE HOSPITAL OF NEPAL
Hypertension is one of the major public health challenges worldwide. Amlodipine, a calcium channel blockers (CCBs), is among the first line antihypertensive drugs used commonly. Amlodipine reduces blood pressure by its vasodilatory action and its adverse drug reactions (ADRs) such as ankle edema, headache and flushing are related with its vasodilatory action. This study is conducted to find the in...
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AN IN-VITRO STUDY FOR MUCOADHESION AND CONTROL RELEASE PROPERTIES OF GUAR GUM AND CHITOSAN IN ITRACONAZOLE MUCOADHESIVE TABLETS
This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar gum ...
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