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ANATOMICAL AND HISTOCHEMICAL CHARACTERISTICS OF MORINDA CITRIFOLIA L. (RUBIACEAE)
Morinda citrifolia (L.) is an important medicinal plant belonging to the family Rubiaceae and commonly known as “Noni” in Tamil was highly distributed in South India. The aim of this research is to understand the concept and techniques of anatomical and histochemical localization of secondary metabolites in Morinda citrifolia (L.) as well as take part in the standardization of herbal medicine....
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1579
PHENOLIC ACIDS AND FREE RADICAL SCAVENGING ACTIVITY OF ALCHEMILLA JUMRUKCZALICA PAWL
Comparative study of free radical scavenging activity and phenolic acid content of Bulgarian endemic Alchemilla jumrukczalica and the commercial herbal - Alchemilla vulgaris complex was carried.The methanol extracts of studied samples showed significant antiradical activity. The concentration of the extracts needed for 50% inhibition of DPPH was found to be 12,09 µg/ml and 19,62 µg/ml for A. jum...
4107
1687
A FACILE SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME MACROCYCLIC COPPER COMPLEXES
Biologically potent compounds are one of the most important classes of materials for the upcoming generations. Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. This initiates a task for current chemistry to synthesize compounds that show promising activity as therapeut...
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2222
DETERMINATION OF CHEMICAL COMPOSITION, TOTAL PHENOLIC CONTENT, TOTAL FLAVONOID CONTENT AND IN-VITRO ANTIOXIDANT CAPACITY OF VARIOUS ORGANIC EXTRACTS OF GYNURA CREPIOIDES LEAVES CULTIVATED IN MALAYSIA
Gynura crepioides, also known as Okinawa Spinach, belongs to the family Asteraceae, which is known to possess various medicinal properties. The present study was thus aimed at determining the GC-MS based chemical profiling, total phenolic content (TPC), total flavonoid content (TFC) and anti-oxidant (AO) capacity of the organic crude extracts such as hexane, chloroform-ethyl acetate, obtained from...
4107
1693
MOLECULAR DOCKING ANALYSIS OF 3- SUBSTITUTED 5-HYDROXY COUMARIN DERIVATIVES AS VITAMIN K EPOXIDE REDUCTASE INHIBITOR
Warfarin and coumarin containing drugs act on Vitamin K epoxide reductase to show its anti-coagulant activity. In this study, three different series of 5- hydroxy coumarin containing phenyl, furan and pyran substituents at third position were designed. Molecular docking studies were performed to determine binding modes and affinities of ligand molecule towards Vitamin K epoxide reductase. In docki...
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1794
EXPLORING THE ANTIMICROBIAL PROPERTIES OF ARTEMISIA ANNUA DURING DIFFERENT FLOWERING STAGES
Many of the plants used to treat certain diseases because they have shown antimicrobial activity. In this case, many studies have conducted on antimicrobial activity of Artemisia annua. The crude extracts obtained from Artemisia annua L. (Asteraceae) were investigated for their antibacterial activity by using agar well diffusion assays against three bacterial species (Escherichia coli, Bacillus su...
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1529
IN VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY OF LEAF EXTRACTS OF BALLOTA NIGRA AGAINST FIVE BACTERIAL PATHOGENS
Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neuro-sedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. The main objective of this study is to evaluate the antibacterial activity of leaf extracts of Ballota nigra Linn. against five bacterial pathogens. The leaves were extract...
4104
1581
INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN-DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
Cyclin dependent kinases (CDKs) are known as cell cycle regulators in eukaryotic cell cycle. Different CDKs (CDK2, CDK4 etc.) are having structure homology among them. Using computer based molecular modeling tools, interactions between naturally occurring terpene based compounds with crystal structure of CDK4 mimic CDK2 enzyme having PDB ID : 1GII. Using In-silico techniques, the binding energies ...
4103
1726
STUCTURAL AND SPECTROSCOPIC STUDY OF Cu(II) – TAURINE –HEXAMINE TERNARY COMPLEX: DETERMINATION OF THE STABILITY CONSTANTS IN METHANOL – WATER MIXTURES
Stoichiometry and apparent stability constant (KC) of the complex formed between Cu(II), hexamine and taurine were determined in water and methanol-water mixtures (% methanol w/w: 3.11; 6.15; 10.4; 15.2; 19.9 and 25.3) by UV–vis spectroscopy at 25o C and constant ionic strength (0.05 M, sodium chloride). Stoichiometry of the ternary complex (1:1: 2, metal: hexamine: taurine) is not modified with...
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1697
HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF BALANITES AEGYPTIACA (L.) DEL AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity i...
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1916