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POLYCYSTIC OVARIAN SYNDROME- A MULTIFACETED DISEASE: A REVIEW
Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders in females of reproductive age. Globally, it has been found that PCOS affects 10% of reproductive-age women when using the NIH criteria for diagnosis, and up to 18% of reproductive-age women are diagnosed with PCOS as per the Rotterdam criteria. Mostly symptoms of PCOS include irregular menstrual cycles, signs of h...
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ANTIFUNGAL ACTIVITIES OF PANGIUM EDULE REINW SEED EXTRACTS INHIBIT THE GROWTH OF ASPERGILLUS FLAVUS, PRODUCER OF AFLATOXINS, THROUGH THE IN-VITRO TEST
Aspergillus flavus is a famous fungus that produces aflatoxins. Aflatoxins are the most well known toxic and carcinogenic chemical prominent produced in nature. The fungus and aflatoxins are the main concern of the corn consumer. Pangi (Pangium edule Reinw) is a potential native plant to reduce infestation of the fungus A. flavus to prevent fungal contamination of food or feed. The research was un...
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EMPAGLIFLOZIN: A REVIEW ON ANALYTICAL AND BIO-ANALYTICAL METHODS
Diabetes mellitus is a metabolic disorder that causes high levels of blood glucose level in that 90% of the diabetic population accounts for type 2 diabetes mellitus it also has secondary complications like Cardiovascular disorder, Renal impairment, and susceptibility to infections. Empagliflozin is a potentially highly selective Sodium-glucose co-transportace-2 (SGLT-2) inhibitor used for the tre...
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RADICAL SCAVENGING POTENTIAL OF CLEOME VISCOSA L. AND CLEOME BURMANNI W. & A. (CLEOMACEAE)
The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the...
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HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY OF METHANOLIC BARK EXTRACT FROM ALBIZIA LEBBECK LINN.
In the present study, high performance thin layer chromatographic method was developed and quantification of Diosgenin from Albizia lebbeck. TLC auminium precoated with silica gel were used as the stationary phase in a twin see through glass chamber saturated with n-butanol: glacial acetic acid: water (4:1:1) mobile phase, performed at room temperature (25ºC ± 2). The Rf value of diosgenin was f...
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A NOVEL APPROACHES FOR DRUG DEVELOPMENT AND PHARMACOLOGICAL STUDY OF HERBAL PLANT
From ancient times, herbal medicines are in use to cure the diseases due to their impending and less side effects. But complications in identification, processing, standardizing, extracting of herbal drugs, it seldom attracts scientists towards the development of novel delivery systems for herbal drugs. During drug development, the complete knowledge of novel scientific approaches like toxicity st...
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ACUTE AND SUBACUTE TOXICITY STUDY ON SPERMATOGENIC SIDDHA DRUG ‘ISAPPUKOL CHOORANAM’ (IC)
Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due t...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF Cu(II), Co(III) AND Fe(III) COMPLEXES OF 2-BENZOYL-3-(NITROPHENYL)QUINOXALINE
A new series of transition metal complexes of the type ML where M = Cu(II), Co(III) and Fe(III) and L = 2-benzoyl-3-(nitrophenyl)quinoxaline have been characterized and the structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis and NMR spectral data. From the spectral measurements and magnetic susceptibility values a square planar g...
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DEVELOPMENT AND VALIDATION OF A HPLC METHOD WITH UV DETECTOR FOR QUANTIFICATION OF GEMIFLOXACIN IN HUMAN PLASMA: APPLICATION TO BIOEQUIVALENCE STUDY
A simple, sensitive, high throughput and specific HPLC method with UV detection was developed and validated to according to the FDA guideline for quantification of gemifloxacin in human plasma. The bioanalytical method consists of liquid-liquid extraction and quantification by UV detection. The analyte was separated isocratically on a Cyano column (250 X 4.6 mm, 5µ particle size) with a mobile ph...
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2055
SYNTHESIS OF THIAZOLIDINONE AND AZETIDINONE DERIVATIVES OF BENZOXAZOLINONE AS ANTIMICROBIAL AGENTS
The present investigation is concerned with synthesis of new substituted benzoxazolinone derivatives (1-18) with the objective of discovering novel and potent antimicrobial agents. The structure of all the synthesized compounds were elucidated by elemental (C, H, N) and spectral (IR, 1HNMR and mass) analysis. The purity of the synthesized compounds was checked by thin layer chromatography (TLC). T...
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