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PIPERAZINE – A BIOLOGICALLY ACTIVE SCAFFOLD
The broad and potent activity of piperazine has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the piperazine in the present context and promise they hold for the future. This review mainly focused the updated information on the most active piperazine derivatives that have been reported to show significant biological actions ...
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ANTI-BACTERIAL EFFICACY OF OCTENIDINE AS A MOUTH WASH
To evaluate the antimicrobial activity of Octenidine (OCT) 0.1%, Chlorhexidine (CHX) 0.2% against bacterial strains of Enterococcus faecalis and Staphylococcus aureus. The strains were inoculated in 7ml of brain heart infusion broth and diluted to reach the concentration equivalent (0.5 McFarland standard). 1ml of organism suspension was contacted with 1ml of each mouthwash and was removed at time...
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ASPECTS OF VALIDATION IN HPLC METHOD DEVELOPMENT FOR PHARMACEUTICAL ANALYSIS – COMPARISON OF VALIDATION REQUIREMENTS BY FDA, USP AND ICH
The most important factor in developing pharmaceutical drug substances and drug products today is ensuring that the HPLC analytical test methods that are used to analyze the products generate reliable, reproducible and meaningful results. The US Food and Drug Administration (FDA) and United States Pharmacopeia (USP) have each documented the importance of this to the drug development process and ha...
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STUDIES ON AN ANTI-AGING FORMULATION PREPARED USING ALOE VERA BLENDED COLLAGEN AND CHITOSAN
Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals po...
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ANTIFERTILITY EFFECT OF AQUEOUS EXTRACT OF INDIGOFERA TRIFOLIATA LEAVES ON REPRODUCTIVE ABILITIES OF FEMALE ALBINO RATS
The present work deals with antifertility effect of the aqueous extract of Indigofera trifoliata leaves in female albino rats. Pregnant rats weighing 120 to 200 gm were randomized into 4 groups. From day 11 upto day 15 of pregnancy, rats were laprotomised on 10th day of pregnancy and live fetuses were observed in both the horns of the uterus. Rats in group 1 (control) were orally administered, wit...
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ZANJABEEL (ZINGIBER OFFICINALE ROSC.): A HOSEHOLD RHIZOME WITH IMMENCE THERAPEUTIC POTENTIAL AND ITS UTILIZATION IN UNANI MEDICINE
The tradition of home treatment is found in all cultures throughout the world whether in developed or developing countries. Few herbal drugs commonly appear in the home use as a medicine. One such drug is Zanjabeel, it is the rhizome of Zingiber officinale Rosc. It is a popular culinary spice that was used as an important medicine by ancient Unani physicians. It is a very important drug of house h...
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PRODUCTION OF SINGLE CELL PROTEIN FROM SUGARCANE USING FUNGI
Single cell protein is a protein extracted from cultured algae, yeasts, or bacteria and used as a substitute for protein-rich foods, especially in animal feeds or as dietary supplements. Many types of animal feeds contain single cell proteins. It can also be called biomass, bioprotein or microbial protein. The word single cell protein which was coined in the 1960 is considered to be appropriate si...
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IN SITU GEL FORMING INJECTABLE DRUG DELIVERY SYSTEM
Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an intensive research have been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in situ gelforming drug delivery systems such as ease of administration and reduced frequency of administration, ...
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ETHNO-MEDICINAL CLAIMS, PHYTOCHEMISTRY AND PHARMACOLOGY OF SPONDIAS PINNATA: A REVIEW
Spondias pinnata is a well-known plant indigenous to South East Asian countries. The plant has been used intensively in many traditional herbal medicines across the globe. This plant has been known to possess antimicrobial, anti-diabetic, ulcer-protective, anti-cancerous, anti-diarrhoeal, anthelmintic, cytotoxic and hepatoprotective activity. It has also been reported that different parts of the p...
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AN OVERVIEW OF TRANSFERSOMAL DRUG DELIVERY
Vesicular systems have gained immense importance in the last few years as a means for sustained and efficient drug delivery. This article was designed to review all aspects of a novel class of vesicles, transfersomes. Tranfersomes and the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. It exists as an ultra-deformable complex having a hydrated core surrounded by...
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