Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
FORMULATION AND OPTIMIZATION OF OSMOTICALLY CONTROLLED, MICROBIALLY TRIGGERED COLON TARGETED SYSTEM USING FACE CENTERED CENTRAL COMPOSITE DESIGN
The purpose of present investigation was to achieve successful delivery especially to colon using microbially triggered, osmotically controlled approach. Prednisolone was chosen model drug for treatment of inflammatory bowel disease (IBD). Prednisolone-β-cyclodextrin complex were prepared and phase solubility study was carried out. Cellulose acetate solution containing chitosan was used to prepar...
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PURIFICATION AND CHARACTERIZATION OF ALKALINE PHOSPHATASE FROM DOLICHOS LAB-LAB AND ITS INVITRO DEPHOSPHORYLATION ACTIVITY ON NUCLEIC ACIDS
Phosphatase serves several functions in plant metabolism including growth governance, phosphorous level control, starch breakdown etc. Alkaline phosphatases, acting at an alkaline pH 8, are a significant class of enzymes that catalyze release of phosphate esters especially. This enzyme study is so far limited only to animal source and partly to microbial sources, in terms of clinical research. Alt...
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DIRECT SPECTROPHOTOMETRIC DETERMINATION OF SATRANIDAZOLE
A direct spectrophotometric method was developed by the authors for the detection and determination of satranidazole in pure form as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of a reddish-purple color dye, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample dissol...
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AMELIORATIVE EFFECT OF HYGROPHILA AURICULATA (K. SCHUM) HEINE ON LIPID PEROXIDATION IN A RAT MODEL OF N-NITROSODIETHYLAMINE INDUCED HEPATOCELLULAR CARCINOMA
This study was designed to investigate the ameliorative effect effect of Hygrophila auriculata (H. auriculata) on lipid peroxidation (LPO) in N-nitrosodiethylamine induced Hepatocellular Carcinoma (HCC) in rats. Experimental rats were divided into different groups: normal, N-Nitrosodiethylamine induced hepatocellular Carcinoma bearing rats, H. auriculata treated hepatocellular carcinoma bearing ra...
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REGULATION OF NON-CANONICAL WNT SIGNALING PATHWAY IN STEM CELLS DEVELOPMENT AND CARCINOGENESIS
Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in developme...
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PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL ACTIVITIES WITH RESPECT TO ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF JATROPHA CURCAS FRUIT
Objective: To evaluate the analgesic and anti-inflammatory effects of the methanolic extract of the Jatropha curcas (MEJC) belonging to the family Euphorbiaceae. Materials and Methods: Phytochemical screening was done by standard procedures. Acute toxicity studies were done by using female albino mice weighing 23-35 gm as per OECD 425 guidelines. In the hot plate models for analgesic activity, the...
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A KINETIC AND MECHANISTIC APPROACH TO PROTECTION AND REPAIR OF TERT-BUTOXYL RADICALS INDUCED URACIL RADICALS BY CHLOROGENIC ACID
The rates of oxidation of uracil and chlorogenic acid (CGA) by tert-butoxyl radicals have been studied by measuring the absorbance of uracil at 258 nm and CGA at 328 nm spectrophotometrically. tert-butoxyl radicals are generated by the photolysis of tert-butyl hydroperoxide in presence of tert-butyl alcohol to scavenge ·OH radicals. The rates and the quantum yields (f) of oxidation of CGA by t-Bu...
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A VALIDATED REPORT ON FORMULATION STABILITY STUDIES OF BENDAMUSTINE HYDROCHLORIDE
The objective of this study was to adopt the analytical method. This adoption procedure was carried out by validating the method parameters and conducting the forced degradation studies to check the interference of the chromatographic response of the degradation products with the drug. In the present study an attempt was made to studies related to system suitability, linearity, accuracy, precision...
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ENHANCEMENT OF DISSOLUTION RATE AND FORMULATION DEVELOPMENT OF RITONAVIR TABLETS EMPLOYING STARCH PHOSPHATE- A NEW MODIFIED STARCH
The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...
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EFFECT OF HYDRO-ALCOHOLIC ROOT EXTRACT OF PLUMBAGO ZEYLANICA L ALONE AND ITS COMBINATION WITH AQUEOUS LEAF EXTRACT OF CAMELLIA SINENSIS ON RESERPINE INDUCED PARKINSONISM
Aim: To investigate the antiparkinsonism activity of hydro alcoholic root extract of P. zeylanica L (PZE) alone and its combination with aqueous extract of C. sinensis leaves (AECS) in reserpine induced model. Materials and methods: Parkinsonism (PD) was induced by sub cutaneous administration of reserpine (1 mg/kg) for 5 days. The extracts/drugs being tested were administered orally (p.o) 60 min ...
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