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DESIGN AND IN-VITRO CHARACTERIZATION OF METADOXINE BUCCAL PATCHES USING BORASSUS FLABELLIFER FRUIT RESIN – A NOVEL MUCOADHESIVE POLYMER
In this study, an attempt was made to introduce a new mucoadhesive polymer - Borassus flabellifer fruit resin (BFR), especially for buccal drug delivery. The novel polymer, in combination with two other natural polymers (Pectin and Sodium alginate) and one synthetic polymer (PVA) were used to formulate buccal patches containing Metadoxine. Compatibility studies carried out with the help of FT-IR s...
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EFFECT OF METHANOL EXTRACT OF ANARCARDIUM OCCIDENTALE (CASHEW) STEM BARK ON SOME BIOCHEMICAL PARAMETERS OF CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
Purpose: Anacardium occidentale (Cashew) has been used by Folk medicines as a remedy for many diseases. In this study, we investigated the ameliorative activity of methanolic stem bark extract of Anacardium occidentale. Methods: Blood samples of the rats from each group were collected by tail bleeding for baseline biochemical test to know the state of the animals’ liver before the inducement of ...
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DEVELOPMENT AND EVALUATION OF GINGER TRANSDERMAL PATCH AND ITS IMPLICATIONS IN MIGRAINE THERAPY
The potential of transferosomal formulation for transdermal delivery of Ginger constituents was investigated. The aim was to reduce the dosage and improve patient acceptance. Transferosomes were formulated by ethanol injection technique using Phospholipids (Lipoid P-100), cholesterol, various edge activators (tween 80, Span 80), and other excipients. Transdermal patches were prepared by solvent ca...
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APPLICATION OF EXTRACT OF GERANIUM PALUSTRE HERB AS A DENTAL FILM IN THE TREATMENT OF ORAL MUCOSA DISEASES
Investigation of antioxidant, anti-inflammatory and antimicrobial activity of a dental film, which easily reabsorbs with applied phytocomplex of Geranium palustre, has been performed to use it for the treatment of oral mucosa diseases. To get the extract, the dried material was grounded, extracted and lyophilized. Quantitative determination of biologically active substances in lyophilized phytocom...
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FTIR SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ARTEMETHER AND LUMEFANTRINE IN BULK AND FORMULATIONS
A FTIR method was developed to estimate Artemether and Lumefantrine simultaneously in bulk as well as in formulations. It is based on the measurement of absorption of radiation at the absorption band of ether at 1113.10-1091.77 cm-1 for ART and phenyl substitution band at 893.65-857.08 cm-1 for LUM, because those absorption bands did not occur in excipients present in a pharmaceutical preparation....
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MOLECULAR DOCKING STUDIES ON PHYTOCHEMICALS OF SOLANUM NIGRUM FRUITS FOR ITS HEPATOPROTECTIVE ACTIVITY
Liver fibrosis is a wound healing process that is initiated in response to chronic liver injury caused by viruses, toxins, and hepatotoxic drugs. This disease is characterized by inflammation, followed by the deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) is identified as a host cofactor for Hepatitis C Virus (HCV) entry. The fruits of Solanum nigrum po...
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AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI-COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN-2-YL-THIAZOLIDIN-4-ONES
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), s...
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SYNTHESIS AND BIOLOGICAL SCREENING OF PYRIMIDINE LINKED BENZENE SULPHONAMIDE DERIVATIVES
Background: It has been developed a new combination of Palladium catalyzed Buchwald-Hartwig type reaction for the synthesis of N-tert- Butyl- 3- {[5- methyl- 2- (arylamino)pyrimidin- 4- yl]amino}benzene-sulfonamides 5 by the treatment of N-tert-butyl-3-[(2-chloro-5-methyl pyrimidin-4-yl)-amino]benzene sulfonamide 4 with various aromatic amines in the presence of Cs2CO3 and in DMF under microwave c...
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PHYTOCHEMICAL SCREENING, POLYPHENOLS CONTENT AND A NOVEL SOURCE OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF ESSENTIAL OIL OF LAURUS NOBILIS FROM MOROCCO
Bacterial resistance and oxidative stress are an important etiology of chronic diseases. This is the reason why new alternatives were established to overcome the incidence of some pathologies. Thus, the present study was aimed to evaluate the antibacterial activity of the extracted oil against bacteria that causes nosocomial infections in neonatal intensive care by using disc diffusion method. The...
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A COMBINATORIAL APPROACH TO IDENTIFY NOVEL HIV-PROTEASE (WILD AND MUTANT) INHIBITORS (PIs) USING ZINC DRUG DATABASE
The Human immunodeficiency virus type-1 protease is one of the most important target to highly active anti retrovirus therapy(HAART) for the treatment of all acquired immune deficiency syndrome(AIDS). Protease inhibitor “Darunavir” is most recently included as a PI in the list of HARRT(highly active anti retrovirus therapy), more effective against mutant and wild type simultaneously of Proteas...
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