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A COMBINATORIAL APPROACH TO IDENTIFY NOVEL HIV-PROTEASE (WILD AND MUTANT) INHIBITORS (PIs) USING ZINC DRUG DATABASE
The Human immunodeficiency virus type-1 protease is one of the most important target to highly active anti retrovirus therapy(HAART) for the treatment of all acquired immune deficiency syndrome(AIDS). Protease inhibitor “Darunavir” is most recently included as a PI in the list of HARRT(highly active anti retrovirus therapy), more effective against mutant and wild type simultaneously of Proteas...
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THE NOVEL CORONA VIRUS (nCoV2) SEEMS TO DEFY ALL LAWS OF VIROLOGY
Amongst the known coronaviruses, many were responsible for causing disease in humans knowingly from the common cold to acute severe respiratory syndrome. The novel coronavirus, nCoV-2 has been implied to cause increasingly severe damage to public health besides demolishing the global economy with a staggering figure of continuous rise in mortality within the afflicted cases in almost every country...
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TOXIC IMPACT OF λ- CYHALOTHRIN ON DNA AND RNA CONTENTS OF THE FISH CTENOPHARYNGODON IDELLA
The synthetic pyrethroids used in agriculture also absorb rapidly via different routes and slowly accumulate into various vital tissues and cause adverse effects on the health status of animals. It leads to produce a number of biochemical changes at the level of nucleic acids. The freshwater fish Ctenopharyn godonidella was exposed to sublethal concentrations (1/10th of LC50 value) of λ- cyhalo...
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HPLC, FTIR AND GC-MS ANALYSIS OF ETHYL ACETATE EXTRACT OF RED SEAWEED HYPNEA FLAGELLIFORMIS GRAVILLE EX J. AGARDH 1851
The experiment was carried out to investigate the phytochemicals constituents of the red seaweed Hypnea flagelliformis (Greville ex J. Agardh. 1851) from Tuticorin coastal waters, Gulf of Mannar, southeast coast of India; by using HPLC, FTIR, and Gas Chromatography-Mass Spectrometry. The selected seaweed was extracted with ethyl acetate (by soxhlet extraction method), furthermore subjected to HPLC...
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THE EFFECT OF KEREHAU LEAF EXTRACT (CALLICARPA LONGIFOLIA LAMK.) ON LIPID RATIOS AND AORTA HISTOPATHOLOGY OF MALE RATS OF WISTAR STRAIN
Ethanol extract of kerehau leaves is known to have anti-inflammatory and antioxidant activities with the potential to prevent atherosclerosis. This study aims to determine the ability of kerehau ethanol extract in reducing the lipid levels, the lipid ratios, and the number of foam cells in the blood vessel walls. This study employed in-vivo and ex-vivo experiments on male rats of Wistar strain ind...
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CLINICAL PHARMACIST ASSESSMENT OF MONITORING AND RESOLVING THE DRUG-RELATED PROBLEMS IN BIPOLAR DISORDER PATIENTS: A PROSPECTIVE, OBSERVATIONAL STUDY AT TERTIARY CARE TEACHING HOSPITAL
Background: Bipolar disorder is a chronic mental illness due to a different interval of manic and depressive phase, the patient may become more prone to DRP, which interfere with the patients’ health outcome. Hence, clinical pharmacist can contribute to managing the DRP through proper pharmaceutical care intervention. Method/Design: A prospective, observational study had been done with 286 parti...
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ISOLATION AND QUANTIFICATION OF GALLIC ACID FROM EULOPHIA OCHREATA LINDL. BY HPTLC
In the healthcare system, the development and modernization of phytomedicine in phytochemistry play a central and important role in drug development. Isolation and purification of bioactive compounds from naturally occurring substance are of prime importance. A sensitive and reliable high-performance thin-layer chromatography method has been developed for the estimation of gallic acid in the alcoh...
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NATURAL OCCURRENCE OF MYCOFLORA AND DETERIORATION OF TOTAL ALKALOIDS AND GLYCOSIDES AMOUNTS IN STEREOSPERMUM CHELONOIDES DC. ROOTS UNDER STORAGE
In the present study, total 15 fungal species isolated from roots of drug Stereospermum chelonoides DC. such as: Fusarium solani, F. lateritum, F. semitectum, F. oxysporum, Aspergillus ochraceus, A. niger, A. terreus, Theilavia terricola, Papulaspora immerse, Scytallidium thermophilum, Didymostilbe sp., Cunningamella elegans, Aphanomyces sp., Sordaria fimicola and Mucor praini. Species of Fu...
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OPTIMIZATION AND DEVELOPMENT OF BIO SYNTHETIC SILVER NANO PARTICLES OF AZURIN- AN ANTI-CANCER AGENT FROM PSEUDOMONAS AERUGINOSA
The pretentious extract of Pseudomonas aeruginosa has shown promising anticancer activity. It contains a protein called Azurin. It has a molecular weight of 14 kDa. It is soluble in water. It is a type I copper-containing protein of cupredoxin family. In this work, Pseudomonas aeruginosa MTCC strain 647 was cultivated in modified Asparagine -proline broth. An attempt was done to isolate and purify...
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QUANTITATIVE EVALUATION OF SOLUBILITY AND SURFACE MICRO-HARDNESS OF ENAMEL ON EXPOSURE TO VARIOUS SOFT DRINKS – AN EX-VIVO STUDY
Objective: To evaluate and compare pH and titrable acidity (TA) of various commonly consumed commercially available soft drinks. To evaluate and compare the weight of enamel dissolution and surface micro-hardness of the tooth after exposure to commonly consumed commercially available soft drinks. Methods: 60 human enamel specimens were randomly divided into 5 groups: Group 1: Kinley water (control...
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