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EFFECTIVENESS OF GUANFACINE IN SMOKING CESSATION – A SYSTEMATIC REVIEW
Background: Guanfacine is a drug used to treat ADHD (attention deficit hyperactivity disorder) and treatment for hypertension from 1986, approved by the FDA. Recently it had been deduced that Guanfacine could also be employed in smoking cessation as a pharmaceutical aid. This could be attributed to the physiological effect that the drug has on the human body, such as decreased heart rate and blood...
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SYNTHESIS AND QSAR STUDY OF NOVEL THIAZOLE MOIETIES HAVING ANTIOXIDANT ACTIVITY
Thiazoles derivatives are an important class of heterocyclic compounds, reported to possess a wide spectrum of biological activities. Moreover, thiazole nucleus occupies a very important place in the field of antioxidant agents. The above observations prompted us to synthesize some novel thiazole derivatives with various substitutions at along with heterocyclic rings in the same framework for syne...
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SURFACE MODIFICATION AND NON-COVALENT FUNCTIONALIZATION OF SINGLE-WALLED CARBON NANOTUBES AND THEIR CHARACTERIZATION
Single-walled carbon nanotubes (SWNTs) though emerged as a promising material for delivery of biomolecules into various cells, due to their high cytotoxicity, they are limited in use in many biological systems and also in humans. The present research explores the preparation of functionalized SWNTs of low cytotoxicity and biocompatibility by altering the size and surface functionalization. Noncova...
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QUALITY BY DESIGN (QbD) BASED DEVELOPMENT OF A STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF COBICISTAT IN BULK
By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of cobicistat has been developed using analytical Quality by design approach. The optimized method was achieved using unisol C-18 (3 μm, 4.6 ×150 mm) column with mobile phase consisting of mixture of water and methanol (70:...
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GAS CHROMATOGRAPHIC DETERMINATION OF FATTY ACID COMPOSITION IN COCONUT OIL EXTRACTED BY PROBE SONICATION TECHNIQUE
Coconut oil is an edible vegetable oil used in the food, pharmaceuticals, and cosmetics industries. Fatty acids are the major constituents of Coconut oil. Various methods were reported for the extraction of oil from coconut seed kernels. Extraction of coconut oil from its seed kernel using the probe sonication method is not reported in the literature. Hence, in the present study, oil was extracted...
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A BRIEF REVIEW ON GLYCOMIMETICS AND THEIR PHARMACEUTICAL APPLICATIONS
This review enumerates the classification, role, and importance of carbohydrate derivatives and glycomimetics. Carbohy-drates are polyhydroxy aldehydes or ketones. Carbohydrates are the most abundant dietary source of energy for all organisms. They are precursors for many organic compounds such as fatty acids and amino acids. They can participate in the structure of cell membranes and cellular fun...
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THE IMPORTANCE OF DOMINANT HAND AT PLACEBO EFFECT OF INERT SPRAY TO MUSCULAR FATIGUE INDUCED EXPERIMENTALLY
Purpose: Placebo effect is a phenomenon where the patient's symptoms can be relieved by a false treatment in pharmacological aspects, most likely because of the patient expectations or believes that the treatment will have success. So, it is a psychological response to the treatment, without being accompanied by the improvement of physical condition. Placebo is often defined as: “Substance or pr...
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DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO SPECTROPHOTO-METRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCl IN BULK AND SYNTHETIC MIXTURE
There are so many promising plant based chemical constituents are present which act as alternative therapy for the control of diabetes. But due to lack of its proper quality control parameters they are not widely used. The US FDA patent is approved for fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Absorbance ratio method uses the ratio of ab...
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ASSESSMENT OF ANTIOXIDANT, CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM
The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant fr...
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PREFERRED SAMPLE FOR THYROID PROFILE IN DIABETIC PATIENTS
Hypothyroidism and Hyperthyroidism are the two primary pathological conditions that involve the thyroid gland. Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Accurate measurement of thyroid hormone concentrations is the key for proper diagnosis of thyroid gland dysfunction. This article is mainly focused on the effect of food on serum levels of...
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