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DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETECTION OF RESIDUAL ETHANOL, ISOPROPYL ALCOHOL AND TOLUENE IN AMIODARONE HYDROCHLORIDE DRUG SUBSTANCE
A simple and reliable head space Gas Chromatographic method has been developed for the determination of residual ethanol, isopropyl alcohol and toluene in Amiodarone hydrochloride drug substance. The proposed method is based on flame ionization detection technique with DB 624 as stationary phase. Linearity of detector response was established up to 150 % of the limit level for ethanol, isopropyl a...
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ANTIDIABETIC ACTIVITY OF 1-(4-(DIMETHYLAMINO)BENZYLIDENE)-5-(2-OXO INDOLIN-3-YLIDENE) THIOCARBOHYDRAZONE IN RATS
Objective: The present study was aimed to evaluate the antidiabetic activity of 1-(4-(Dimethylamino) benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone i.e. a novel Isatin derivative diabetic rats. Methods: The antidiabetic activity of Isatin derivative was evaluated against alloxaninduced diabetes in rats. Diabetes in rats was induced by administration of alloxan monohydrate (120...
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2033
A COMPREHENSIVE REVIEW OF XANTHENE AND THIOXANTHENE
Xanthene (or 9H-xanthene) is a parent active compound in which a pyran ring is combined with a benzene ring on both sides, whereas in thioxanthene, the oxygen of xanthene is replaced by a sulphur atom. Xanthene and thioxanthene are important classes of organic compounds which exhibit diverse pharmacological activities such as anti-spasmodic, anti-parkinsonian, anti-psychotic, anti-rhinitic, anti-i...
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FORMULATION, OPTIMIZATION AND EVALUATION OF HEXADECANOIC ACID PHYTOSOMAL GEL FOR ANTI-FUNGAL ACTIVITY
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid...
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1416
SURFACE MODIFICATION AND NON-COVALENT FUNCTIONALIZATION OF SINGLE-WALLED CARBON NANOTUBES AND THEIR CHARACTERIZATION
Single-walled carbon nanotubes (SWNTs) though emerged as a promising material for delivery of biomolecules into various cells, due to their high cytotoxicity, they are limited in use in many biological systems and also in humans. The present research explores the preparation of functionalized SWNTs of low cytotoxicity and biocompatibility by altering the size and surface functionalization. Noncova...
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1683
ASSESSMENT OF ANTIOXIDANT, CYTOTOXIC AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT FRACTIONS OF CRUDE EXTRACT OF STEPHANIA JAPONICA STEM
The different fractions of crude methanolic extract of stem of Stephania japonica (Thunb.) Miers was evaluated for antioxidant, cytotoxic and antibacterial activities. The various fractions of S. japonica Stem i.e. Ethyl Acetate (EAJS), CHCl3 (CFJS), CCl4 (CTJS) and Petroleum ether (PEJS) were subjected to free radical scavenging activity. In this investigation, CFJS showed the most significant fr...
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1682
CHARACTERIZATION AND EVALUATION OF NIZATIDINE FLOATING MICROSPHERES BASED DRUG DELIVERY SYSTEM FOR ANTI-ULCER ACTIVITY
Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floati...
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1752
PREFERRED SAMPLE FOR THYROID PROFILE IN DIABETIC PATIENTS
Hypothyroidism and Hyperthyroidism are the two primary pathological conditions that involve the thyroid gland. Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Accurate measurement of thyroid hormone concentrations is the key for proper diagnosis of thyroid gland dysfunction. This article is mainly focused on the effect of food on serum levels of...
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1432
QUALITY BY DESIGN (QbD) BASED DEVELOPMENT OF A STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF COBICISTAT IN BULK
By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of cobicistat has been developed using analytical Quality by design approach. The optimized method was achieved using unisol C-18 (3 μm, 4.6 ×150 mm) column with mobile phase consisting of mixture of water and methanol (70:...
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1444
FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN SENILITY INDUCED STERILITY OF MALE WISTAR RATS – A HISTOMORPHOMETRIC STUDY
Ageing is associated with the diminished function of various tissues in the body. The gonadal function declines with age. In male, there is progressive atrophy of the sperm producing elements of the testes, resulting in diminished spermatogenesis. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium ...
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