Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
THE ROLE OF β-ENDORPHIN AND C-PEPTIDE IN STREPTOZOTOCIN INDUCED DIABETIC RATS WITH EFFECT OF ACU-TENS AT ZUSANLI (ST36) ACUPOINTS
Streptozotocin is 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose drug is commonly used to induce diabetes in experimental rats. This study was designed to evaluate the role of β-endorphin and C-peptide in Acu-TENS therapy at Zusanli (ST36) acupoint. Diabetic was induced by Streptozotocin (45mg/kg/body weight) with a single dose of intraperitoneal injection in male albino Wistar rats. The di...
4192
1021
FABRICATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE LOADED MICROSPHERES BY INCORPORATING NATURAL AND SYNTHETIC POLYMERS FOR COMPARATIVE ANALYSIS
The present developed method was designed to fabricate an innovative, simple, cost-effective, and compatible method for controlled delivery of Metformin hydrochloride (MF) by the use of natural and synthetic polymers for comparative analysis. For the most commonly used anti-diabetic drug Metformin hydrochloride, we have tried to formulate microspheres by incorporating natural and synthetic polymer...
2200
1262
G-QUADRUPLEX MOTIFS IN C MYC PROMOTER REGION AND THE ROLE OF VARIOUS SMALL MOLECULE LIGANDS/PROTEINS IN STABILIZING THIS PROMOTER REGION
One of the essential scientific research concluded that DNA / RNA forms the hereditary or the genomic material in all life forms. The double-helical model given by Watson and Crick further added to the biological findings, and since then, various other DNA structures have been established viz., triple-stranded structures, quadruplexes, higher-order structures such as G-wires, polyads, etc. This re...
2969
1763
SMARTPHONE IS IT “BEHAVIOUR ADDICTION OR SUBSTANCE ABUSE DISORDER”: A REVIEW TO FIND CHEMISTRY BEHIND
Several behavioral addictions have been hypothesized as having similarities to substance abuse addictions. The DSM-4-TR has designated formal diagnostic criteria for several addictive disorders classifying them as impulse control disorders, a separate category from substance use disorder. There have been a lot of behavioral addiction studies like tanning, cosmetic surgery, sexual addiction, etc....
4708
2341
ROLE OF POLYMERS IN SUSTAINED RELEASED MICROBEADS FORMULATION: A REVIEW
The aim of this article is to provide a wide-angle prospect of the detailed information of pharmaceutical polymers in sustained released micro-beads dosage forms. Polymers have played an integral role in the advanced drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and constant release of both hydrophilic and hydroph...
3831
1639
GENETIC BACKGROUND ASSOCIATED WITH THE PROGRESSION OF NON- ALCOHOLIC FATTY LIVER DISEASE TO LIVER FIBROSIS
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAF...
2013
1265
FORMULATION OF MICRO BEADS: A REVIEW
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration. This could be achieved through multiparticulate dosage form like beads which are divided into many individual units, so, called subunits, each exhibiting some desired characteristics. Micro particulate drug delivery systems ...
7448
10409
DESIGN, DEVELOPMENT AND SYNTHESIS OF NOVEL CHIRAL DERIVED MOLECULES, POTENTIALLY ACT AS RNA POLYMERASE NSP-12 AND NSP-6/10 COMPLEX INHIBITORS AGAINST COVID-19
Novel Di and Tridentate chiral molecules and its analogues were designed and synthesized in that the chiral amino ester and 2-amino-3, 5-dibromobenzaldhehyde were condensed. Further, it has coupled with Cassic acid to form desired active molecules. The developed compounds are evaluated for molecular docking to check potency and may represent potential drug candidate inhibitors of RNA dependent RNA...
2782
2184
IN-SILICO BINDING AFFINITIES OF ALKALOID COMPOUNDS ON NICOTINIC ACETYLCHOLINE RECEPTOR α3β4 FOR SMOKING CESSATION TREATMENT
Nicotinic acetylcholine receptor α3β4 is considered as a potential target for anti-smoking drug discovery. In this study, in-silico approaches, including molecular docking and molecular dynamics simulation were applied to investigate binding affinities of 300 alkaloids into the α3β4 (Pdb id: 6PV8). The docking results showed that most of the alkaloids fitted well into the binding pocket of α3...
4773
1776
PROTECTIVE ROLE OF MELATONIN AND TAURINE AGAINST TOXICITY INDUCED BY CAFFEINE IN BRAIN BY ABROGATION OF OXIDATIVE STRESS, DECREASE APOPTOSIS, AND ALTERS CEREBRAL MONOAMINE NEUROTRANSMITTERS IN MALE ALBINO RATS
The current study aimed to investigate the protective effects of taurine and melatonin against caffeine-induced brain damage in rats. 36 male albino rats were divided into 6 groups: Group I: control, group II: Rats received 20 mg/kg melatonin for 28 days. Group III: Rats received 50 mg/kg taurine dissolved in distilled water daily for 28 days. Group IV: Rats received 50 mg/kg caffeine dissolved in...
3838
1819