Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
FORMULATION DESIGN OF EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE EXTENDED RELEASE TABLETS: OPTIMIZATION OF FORMULATION USING STATISTICAL EXPERIMENTAL DESIGN
The objective of the present study was to develop Empagliflozin and Metformin hydrochloride extended release tablets, comprising immediate release empagliflozin and extended release metformin hydrochloride in a single tablet. Wet granulation process was employed to develop extended release part metformin hydrochloride. Impact of various formulation variables in extended release part was assessed u...
5172
2977
ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PATHOGENIC BACTERIA CAUSING URINARY TRACT INFECTION IN TERTIARY CARE HOSPITAL IN KATHMANDU, NEPAL
Urinary tract infection (UTI) is one of the common clinical conditions in patients presenting to the tertiary care hospital. In general, most of the case of UTI was being treated by empirical antimicrobial therapy before the laboratory results of urine culture; since the antimicrobial susceptibility test of uropathogenic bacteria and antibiotic resistance for enhanced management of UTI with a comm...
2778
1045
PHYTOCHEMICAL SCREENING, IN-VITRO EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL EFFICACY OF METHANOLIC LEAF EXTRACT OF CLINOPODIUM NEPETA (L.) KUNTZE
The objective of the present study is to evaluate the phytochemical constituents, antioxidant and antibacterial activities of methanolic leaf extract of Clinopodium nepeta (L.) Kuntze. Total phenolic content of leaf extracts was assessed using Folin-Ciocalteu and AlCl3 reagent. Antioxidant assays were evaluated using DPPH, ABTS radical scavenging, and ferric, reducing antioxidant power (FRAP) meth...
2242
1661
BIOACTIVE COMPOUNDS PROFILING AND STRUCTURE ELUCIDATION OF MARTYNIA ANNUA L. HERB
The medicinal herbs used by native people of Mexico since ancient times for numerous therapeutic purposes. The plant is inborn to Mexico but is now well familiarized throughout India on wastelands. In India Martynia annua L. is a well recognized small herbaceous annual plant. The present study was carried out with HPTLC, and the results showed that there were many photochemical in Martynia annua L...
2331
1279
IN-VIVO ANTICONVULSANT ACTIVITY OF 2-SEMICARBAZONO-1-HYDROXY, 1-[2-CHLOROPHENYL] -2-[4′-METHOXYPHENYL] ETHANE
A benzoin derivative of 2-Semicarbazono-1-hydroxy, 1-[2-chlorophenyl]-2-[4'-methoxyphenyl] ethane (2C4MBS) was synthesized by benzoin condensation followed by addition reaction. The structure elucidation done using single XRD studies. Maximal electroshock seizure (MES) model was used in the present study to evaluate the anticonvulsant activity of the test drugs. MES seizures were induced by an ele...
1903
2345
THE THEORETICAL STUDIES OF MOLECULAR ORBITALS AND THERMODYNAMIC PROPERTIES OF ANTIFUNGAL DRUG
In this work, the molecular structure optimization, electronic properties like local chemical reactivity descriptors (Fukui function analysis for reactive site prediction), and thermodynamic properties (Heat capacity, entropy, zero points vibrational energy, thermal energy, translational, rotational and vibrational energy) of antifungal drugs were theoretically computed. In this work also, electro...
1993
1039
EVALUATION OF IN-VITRO ANTIOXIDANT AND NEPHROPROTECTIVE POTENTIALS OF CRINUM ASIATICUM BULBS AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN ALBINO RATS
Objective: To study the in-vitro antioxidant as well as nephroprotective potentials of Crinum asiaticum bulbs’ethanolic extract in contrast to gentamicin-induced nephrotoxicity in albino rats. Materials and Methods: The ethanolic extract of Crinum asiaticum bulbs subjected to preliminary phytochemical analysis to determine the phytoconstituents and evaluation of antioxidant activity was done usi...
1964
1043
RECENT ADVANCES TOWARDS THE DEVELOPMENT AND APPLICATIONS OF NOVEL THERAPEUTICS AGAINST CHIKUNGUNYA VIRUS INFECTIONS
Chikungunya infection, caused by the flavivirus Chikungunya, spreads from one person to another by two species of Aedes mosquitoes, i.e., Aedes albopictus and A. aegypti. There is a rapid global emergence and resurgence of Chikungunya infections in India and the Indian Ocean Islands, making it a public health emergency around the globe. There are numerous strategies being adopted by this arbo...
1982
1014
AN AESTHETIC RECONSTRUCTION OF GROSSLY DECAYED PRIMARY ANTERIOR TEETH – A CASE REPORT
Background: Early childhood caries is a rapidly progressing type of dental caries in children. It can lead to partial or complete loss of crown structure. Grossly decayed anterior teeth often lead to discomfort, and the child may face psychological, aesthetic, functional, and phonetic problems that affect the quality of life of the child, and it poses a challenge for the dentist to preserve the te...
2478
1056
DESIGN AND OPTIMIZATION OF OLANZAPINE IMMEDIATE RELEASE TABLETS USING NATURAL SUPER DISINTEGRANTS BY RESPONSE SURFACE METHODOLOGY
Purpose: To formulate and evaluate Olanzapine immediate-release tablets using direct compression. Immediate release of drug from the dosage form is required for rapid onset of action and produce an immediate therapeutic effect. Method: Tablets were formulated using two different natural super disintegrants like Fenugreek and Isabghul and in combination by using Response Surface Methodology. The se...
2101
1156