Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
A PRELIMINARY INVESTIGATION OF TUMOR TAKE INHIBITORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MURRAYA KOENIGII LINN. IN MICE
The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth o...
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A REVIEW ON DELIVERY OF ANTIHYPERTENSIVE DRUGS THROUGH SUBLINGUAL ROUTE
Hypertension is a major risk factor in the development of cardiovascular diseases and has emerged as one of the largest death causing diseases for mankind. There are number of medicines useful for treatment of high blood pressure but the main obstacle for the oral delivery of antihypertensive drugs is low bioavailability due to first pass metabolism. Also, if there is sudden increase in blood pres...
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INFLUENCE OF LEVETIRACETAM ON AGGRAVATION OF MEMORY IMPAIRMENT BY VALPROATE: A STUDY ON PILOCARPINE MOUSE MODEL OF TEMPORAL LOBE EPILEPSY
Association of memory impairment (MI) with epilepsy, majorly in temporal lobe epilepsy (TLE) is considerably a tricky condition where existing treatment options involving the administration of anti-epileptic drugs (AED’s) tend to worsen the stated incidence. This study evaluates the aggravating effect of valproate (VAL) at normal and reduced doses on MI associated with TLE and additionally asses...
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VIRTUAL SCREEENING AND PHARMACOLOGICAL EVALUATION OF NEWER BTK INHIBITIORS AS POTENT ANTI-RHEUMATOID ARTHRITIC AGENTS
Rheumatoid arthritis is a chronic autoimmune disease affecting 1% of the world wide population. Recent researches suggested that the need for discovery of new therapeutic disease modifying anti-rheumatoid arthritis drugs (DMARD’s). BTK (Bruton’s tyrosine kinase) is cytoplasmic, non receptor tyrosine kinase and it is efficient target for the treatment of rheumatoid arthritis. This encouraged us...
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EVALUATION OF HEPATOPROTECTIVE AND ANTI-OXIDANT ACTIVITY OF ROOT EXTRACTS OF AEGLE MARMELOS IN CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY WISTAR ALBINO RATS
Herbal medicines are effective in the treatment of various ailments. Very often these drugs are unscientifically exploited and / or improperly used. Therefore plant drugs deserve detailed studies in the light of modern science. The detailed investigation and documentation of plants used in local health traditions and pharmacological evaluation of these plants and their taxonomical relatives can le...
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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF NITROFURANTOIN IN HUMAN PLASMA BY LC -MS / MS
A simple, rapid and sensitive method using an isocratic Liquid chromatography coupled with Tandem mass spectrometry was developed and validated for the assay of nitrofurantoin in the Human Plasma. The Mass transition of nitrofurantoin and losartan (Internal standard) were M/z 237.1/151.9 and M/Z 421.300/ 179 in ESI Negative ionization. Linearity was observed between the nitrofurantoin concentratio...
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SYNTHESIS AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES (MSN) LOADED COX-II INHIBITOR – MELOXICAM FOR TARGETED COLORECTAL CANCER TREATMENT
Polymer functionalised mesoporous silica nanoparticles hold great promise to enhance drug targeting and cell internalisation for cancer cells. Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles (MSN) were used as folate marker and polyethyleneimine was used to improve cell internalisation. Meloxicam was loaded into the pores o...
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PHYTO-FABRICATION OF SILVER NANOPARTICLES BY DIFFERENT PHYSICO-CHEMICAL PARAMETRES USING PETREA VOLUBILIS L. LEAF BROTH AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanopartic...
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PREVENTION OF GASTRIC EROSION IN INDOMETHACIN ADMINISTERED RATS BY SELECTED ANTIOXIDANTS, VITAMINS AND MINERALS
This investigation was aimed to study the effect of few selected antioxidants, Vitamins and minerals for prevention of gastric erosion in indomethacin induced gastric mucosal damage in rats. Male Wistar rats, weighing between 200 -250 g were divided into 9 groups of 6 animals each (n = 6). The groups were treated respectively as follows Group I normal control and Group II disease control received ...
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ANTI – AGEING ACTIVITY OF MOONG BEAN SPROUTS
The present work was undertaken to justify that Vigna radiate (green moong bean) is helpful in reversing signs of memory loss in aged mice. Passive Avoidance Paradigm (PAP) and Elevated Plus Maze (EPM) were employed as exteroceptive behavioural models and ageing- induced amnesia served as interoceptive behavioural model. Moong bean sprouts (2% and 4% w/w MBS) were administered to mice along with ...
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