Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
PROTEIN INTERACTION NETWORK AND DRUG DISCOVERY
Protein conformation and dynamics are influenced by various factors, including binding of ligands, their physico-chemical properties, etc. Every conformational change is dictated by an array of events, as making and breaking of bonds or change in interaction of protein residues. The three dimensional structure of protein molecules are widely investigated, based on small world network approaches, w...
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THE REDUCTION IN CORTISOL INDUCED STRESS MARKERS BY THE AQUEOUS EXTRACT OF CLERODENDRUM COLEBROOKIANUM
In the present competitive world, stress is a major cause for several health disorders– Hypertension, Cardiovascular disorders, Supressed Immunity and other conditions. Proper stress management takes on great importance given the wide range of bodily systems impacted by stress hormones. Cortisol – the “stress hormone” affects the liver by increasing several biochemical pathways. One of the...
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF HEPATOCYTES REGENERATOR POTENTIALITY OF SOME NOVEL OXADIAZOLE DERIVATIVES FOLLOWED BY MOLECULAR DOCKING AGAINST NF-KB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4...
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MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV-1-RT INHIBITORS
Molecular docking studies of 102 newly designed N-substituted imidazoles was performed in the non nucleoside inhibitory binding pocket of reverse transcriptase enzyme of wild type as well as resistant strains of HIV-1 virus with PDB ID 1RT2, 1JLB, 3BGR and 1FK9 respectively by using Glide 5.0 to carry out a binding mode analysis of the designed imidazoles. Results generated from this study indicat...
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1056
ANTI – INFLAMMATORY ACTIVITY OF EXTRACTS OF WOODFORDIA FRUTICOSA STEMS BARK IN ANIMAL MODELS
Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblast...
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ISOLATION, PURIFICATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEINS FROM INDUCED LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Antibacterial proteins are evolutionarily ancient, effect or molecules of innate immune defense and are ubiquitously found in all kingdoms. The present study deals with the induction of antibacterial proteins in the haemolymph of Anthereae mylitta drury (Daba TV) by injecting non-pathogenic Pseudomonas DAS-01. Purified protein fraction obtained on ammonium sulphate precipitation followed by ion ex...
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933
LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION
The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...
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ROLE OF EMBLICA OFFICINALIS IN MITIGATING THE SULPHUR DIOXIDE INDUCED TOXICITY IN RATTUS NORVEGICUS (BERKENHOUT)
SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets - control set (1) were kept in control conditions, while, rats ...
2453
978
POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’ TRIAL
Purpose: Several medications are currently available for trying smoking cessation, such as nicotine replacement therapy or antidepressants. This study investigates potential effect of Meclezine-B6 combination; and B6 tablets administrated orally for possibility of reducing number of cigarettes smoked per day during 10 days. Methods: Using placebo control study. In which adult smokers' volunteers w...
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QUASI-EXPERIMENTAL STUDY OF THE EFFECT OF PATIENT COUNSELING ON QUALITY OF LIFE AMONG TUBERCULOSIS PATIENTS
Objectives: Tuberculosis (TB) remains one of the most substantial infectious causes of death in the world. Studies focusing on the quality of life (QOL) among TB patients are limited and the effect of counselling on patients QOL has not been well-studied. The aim of this study was to assess the effect of patient counselling on QOL among patients with Tuberculosis. Methods: A quasi-experimental stu...
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