Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY OF VALSARTAN USING HOT MELT EXTRUSION TECHNIQUE
The aim of present study is to improve the aqueous solubility of valsartan by utilizing hot melt extrusion technique (HME). Hot melt extrudates were prepared by novel polymeric matrices such as HPMCAS and Plasdone S630 copovidone at different ratios. The solubility studies of extrudates, showed a significant improvement in aqueous solubility. Gastroretentive floating tablets of valsartan using its...
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THE EFFECT OF GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) ON LITHIUM-INDUCED LOCOMOTOR ACTIVITY IN RAT
Ginger has shown to benefit in muscular pain due to eccentric exercise and in osteoarthritis but a later review denied these properties due to uncertainties. To ascertain the reality, this study was proposed. Methods: (A) Albino rats (n=6-12) were administered G.J at single dose (4 ml/rat, p.o) as single administration (acute) and chronic treatment 4ml/rat p.o over period of 7 days. Following this...
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STUDY ON DETECTION METHODS FOR NOREPINEPHRINE IN BIOLOGICAL SAMPLES
Norepinephrine (NE) is an important catecholamine neurotransmitter that acts as a biochemical messenger in central nervous systems and neuronal cells of mammals, which is secreted and released by the adrenal medulla and the noradrenergic neurons during the synaptic transmission. It is often used for treating bronchial asthma, myocardial infarction hypertension and organic heart disease. Abnormal r...
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A REVIEW ON THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PIPERIDIN-4-ONES K. P. Greeshma * and S. Muthulingam
Piperidine is a key structural motif in various alkaloids and a variety of compounds studied in medicinal chemistry. Though many methods have been developed for their construction, there is still need for noval approaches. Among the wide variety of heterocyclic compounds; piperidin-4-ones exhibit various biological activities. Synthesis and biological applications of piperidin-4-ones derivatives a...
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STEM CELLS IN REGENERATIVE ENDODONTICS
Endodontic treatment is helpful in saving millions of teeth each year, but at present the focus has shifted towards regenerative approaches as an ideal form of therapy to treat diseased or necrotic pulp tissues. Regeneration of lost tissues has been known for a very long time, but their use in dentistry is gaining momentum. The growing understanding of biological regeneration has permitted the use...
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IN SILICO FINDING OF THE PUTATIVE DRUG TARGETS FROM HYPOTHETICAL SET OF PROTEINS FOR MYCOBACTERIUM LEPRAE TN
Leprosy is a chronic granulomatous disease caused by acid-fast bacilli Mycobacterium leprae. It is most prevalent in tropical countries and poses a threat to over 122 countries across the globe. In 2012, 232857 new cases of leprosy were registered in the world. World Health Organization (WHO), recommended the Multi Drug Therapy (MDT) for treatment of leprosy, but the minimum duration of treatment ...
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SCHIZOPHRENIA: A LOOK FORWARD WITH ZINC06025953
Phosphodiesterase PDE10A is an enzyme that has established connection earlier with schizophrenic condition, schizophrenia is well known severely chronic and disabling disease worldwide today. Unfortunately, there is no concrete evidence till day to point out as a single cause of this disease. However, in a recent work a research team of Merck Research Group recognized earlier pyp-1 as an effective...
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DEVELOPMENT OF ONDANSETRON HCL FAST DISINTEGRATING TABLETS USING 32 FULL FACTORIAL DESIGN
The present investigation was carried out to study the disintegrant property of Plantago ovata and Ocimum basilicum mucilages. The objective of the work was to develop Fast disintegrating tablets of Ondansetron HCl with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata (2-10% w/w), Ocimum basilicum (4-8%w/w) muci...
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A RANDOMIZED CLINICAL TRIAL TO ASSESS AND COMPARE THE ANTIMICROBIAL ACTIVITY OF PLANTS OF LYTHRACEAE FAMILY WITH HIORA MOUTH WASHES IN SUBJECTS WITH CHRONIC PERIODONTITIS – “UNVEILING THE UNSEEN EFFECTS”
Aims and objectives: Periodontal disease is the most common disease associated with microbial infection with destruction of supporting structures. The aim of the present study is compare the antimicrobial efficacy of plants of lythraceae family with hiora mouthwash in subjects with chronic periodontitis. Materials and methods: A total of 90 subjects were taken and randomly divided into three group...
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VARIATION IN RESIN DUCTS AND YIELD IN CHIR PINE POPULATION
Pinus roxburghii (F-Pinaceae) is one of the most common chir-pine found in the mid-Himalayan region. The crown of this species displays two different needle colour morphotypes (Dark- Green, Light- Green). It is a well known timber and resin yielding tree. Wood exudes oleoresin which yields rosin and turpentine oil having important role in commercial industry. So, the present study was focused on t...
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