AN OVERVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUES FOR POORLY SOLUBLE DRUGS AND SOLID DISPERSION AS AN EMINENT STRATEGIC APPROACH
Solubility is an important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Among all newly discovered chemical entities most of the drugs are lipophillic and fail to reach market due to their poor water solubility. The solubility behavior remains one of the most challenging aspect informational development. Hence various techni...
Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages. India is slated to be the diabetic capital of the world, with 50.8 mill...
DASAPUSHPAM: THE TRADITIONAL USES AND THE THERAPEUTIC POTENTIAL OF TEN SACRED PLANTS OF KERALA STATE IN INDIA
The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day ...
The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and vari...
L-Asparaginase (E.C. 184.108.40.206.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. This article has briefly touched nearly all the industrial and clinical aspects of L-Asparaginase and provides the recent update of the topic. The article includes a brief introd...
The nanoemulsion is one of the most efficient dispersed nanosystems of droplet size ranging to submicron size. Nanoemulsion are generally transparent or semi transparent system characterized by high stability. They are characterized by high stability. Submicron droplet size and high surfactant concentration makes it an efficient transdermal delivery vehicle. Research works proves that nanoemulsion...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF GLICLAZIDE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION METHOD
A simple, rapid, accurate, precise, specific and economical spectrophotometric method for simultaneous estimation of Gliclazide (GLC) and Metformin hydrochloride (MET) in combined tablet dosage form has been developed. It employs formation and solving of simultaneous equation using two wavelengths 227.0 nm and 237.5 nm. This method obeys Beer’s law in the employed concentration ranges of 5-25 μ...
Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’ is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive and diuretic activities. Several pyrrolizidine alkaloids have been isolate...
Pomegranate, Punica granatum L. (Punicaceae), as a medicinal and nutritional ancient fruit, has an outstanding medical history throughout the world. Each of compartments of pomegranate has interesting pharmacological activity. Juice, leaf, flower, and peels of pomegranate possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic activity. Pomegranate seeds have eth...
Tinospora cordifolia (Thunb.) Miers, (Guduchi) is an evergreen perennial climber. This deciduous and dioecious plant belongs to the family Menispermaceae. It is a plant of significant medicinal importance in the Indian system and designated as Rasayana. Its efficacy has been also recognized by the modern system of medicine. The whole plant is used medicinally however; the stem is approved for us...