The nanoemulsion is one of the most efficient dispersed nanosystems of droplet size ranging to submicron size. Nanoemulsion are generally transparent or semi transparent system characterized by high stability. They are characterized by high stability. Submicron droplet size and high surfactant concentration makes it an efficient transdermal delivery vehicle. Research works proves that nanoemulsion...
HYPOLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF ETHANOLIC EXTRACT OF IMMATURE LEAVES OF MANGIFERA INDICA (LINN.) IN ALLOXAN INDUCED DIABETIC RATS
The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of immature leaves of Mangifera indica. The different fractions of extract were administered intraperitonially as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid...
Alopecia is the medical term for hair loss or baldness. It is a health condition in which hair is lost from some or all areas of the body, usually from the scalp. Hair loss can be caused due to different reasons, such as genetic tendencies, environmental triggers, exposure to chemicals, medicines, nutritional deficiency, extreme stress or long illness etc. On the basis of hair loss pattern and c...
Medicines obtained from plant source are known as an herbal medicine, and the herbal medicine are one which make human healthy without causing any of harmful effect. Madhuca Indica is a plant of Indian origin having tremendous therapeutic potential but is not fully utilized. It is hidden from the eyes of the researchers and other botanist. Madhuca Indica has several pharmacological activity, and p...
Niosomes are self assembled vesicles composed primarily of synthetic surfactants and cholesterol. They are analogous in structure to the more widely studied liposomes formed from biologically derived phospholipids. Niosomes represent an emerging class of novel vesicular systems. Niosome formation requires the presence of a particular class of amphiphile and aqueous solvent. In recent years a compr...
RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF IRBESARTAN, LOSARTAN, HYDRO-CHLOROTHIAZIDE AND CHLORTHALIDONE–APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Irbesartan, Losartan, diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Hypersil BDS (Length 250 mm × Diameter 4.6 mm Particle size 5 μm) column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 ...
ANALYSIS OF BIOACTIVE COMPOUNDS AND ANTIMICROBIAL ACTIVITY OF MARINE ALGAE KAPPAPHYCUS ALVAREZII USING THREE SOLVENT EXTRACTS
The seaweeds are economically valuable resources, used as food, fodder, fertilizer and medicine and thus useful to mankind in many ways. In the present study, Kappaphycus alvarezii, a marine alga, has been analysed for the presence of bioactive products using three solvent extracts. Antimicrobial activity was also done using the same extracts of seaweed. The results revealed that the selected seaw...
Mushrooms are an important natural source of food and medicines. Traditionally medicinal properties of mushroom have been well demonstrated particularly in Eastern Asian countries. In modern clinical practices, the bioactive compounds derived from the extract of mushroom sporocarps or mycelium has been widely used for the prevention and treatment of various human diseases such as cancer, diabetes,...
A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FEBUXOSTAT IN BULK AND PHARMACEUTICAL FORMULATIONS
A simple and cost effective spectrophotometric method is described for the determination of febuxostat in pure form and in pharmaceutical formulations. The drug was highly soluble in methanol so it was selected as the solvent system for the drug. This ensured adequate drug solubility and maximum assay sensitivity. The linearity range for febuxostat at its wavelength of detection of 315 nm was obta...
This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the rhizome of Costus speciosus (Zingiberaceae). The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, total phenolic content and flavonoid content were studied. Costus speciosus exhibited potent total antioxidant activity which was expressed as an eq...