Posted by admin on Dec 31, 2021 in |
Molecular object precise healing designed for the malignancy be unrelated as of the predictable therapy, as well as radio healing in conditions of selectivity and specificity target to the malignant tyrosine kinase, is well-thought-out additional shows potential molecular intention for invention and expansion of the new cytotoxic drug molecules. Epidermal growth factor receptor is overexpression irregulation or alteration are experiential in the various types of epithelial type cancer such as non-small cell lung cancer (NSCLC), carcinoma of the breast, colon, etc., in the present research carry out molecular modeling study approaches on quinazolinone derivatives as EGFR Inhibitors with the put of 20 drug molecules will be taken to show the relationship of the structural parameters, a drug like properties by using molinspiration technique and further, molecular docking simulation was done and find the interaction of Ligands active position of EGFR, as well as computational study, was carried out which results in the prediction of pharmacokinetic & bioactivity properties. Moreover, the results of this work afford the information related to...
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Posted by admin on Dec 31, 2021 in |
Background: Beta-glucogallin (BGG) is a tannin precursor naturally found in a variety of plants such as gooseberry, raspberry, amla, etc. BGG was reported to be a potential therapeutic agent in managing a variety of diseases. This investigation was intended to assess whether BGG alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with the cholinergic system and antioxidant effects. Materials and Methods: Two doses of BGG (5 & 10 mg/kg) were tested in the exteroceptive and interoceptive amnesia model: Morris Water Maze test, Elevated plus-maze model, scopolamine-induced amnesia and assessment of motor coordination activity. The assessment of in vitro antioxidant activity by DPPH method and molecular docking analysis was also performed. Results: Pre-treatment with BGG at doses 5 and 10 mg/kg have shown significant anti-amnesia activity in the behavioral models in a dose-dependent manner.BGG at a lower dose did not impact the motor coordination activity of mice; however, at a higher dose, the results did not show a major impact, though the results look statistically...
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Posted by admin on Dec 31, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorder, bronchitis, and in asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydro-alcoholic extract of E....
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Posted by admin on Dec 31, 2021 in |
A new series of Schiff’s base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and fungal species C. albicans and A. clavatus are selected based on their clinical and pharmacological importance. Bacterial and fungal tests were performed under the same conditions using Cefixime and Griseofulvin as standard drugs. It has been found that synthesized Schiff’s base has shown efficient antibacterial and anti-fungal activities. Thus they can be revealed as potent antimicrobial compounds. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The structures of synthesized compounds were confirmed by TLC, melting point, Infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy (1HNMR)...
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Posted by admin on Dec 31, 2021 in |
An extensive range of studies have shown plant extracts and their phyto-constituents efficacy, proposing them as a promising alternative for treatment or as adjuvants in human diseases such in skin, gastrointestinal, systemic and dental conditions, due to various active components presence, ease of access and reduced side effects. Indeed, depending on solvent used to obtain the extract, its active molecules may vary, including flavonoids, tannins, alkaloids, terpenes, sesquiterpenes, sterols, among others. Extract content (crude/partition/fraction) has pharmacological advantages over isolated compounds, due to pleiotropic activity and synergistic effect between components. Due to factors such as low bioavailability, solubility, and stability, it is difficult to translate its in-vitro and in-vivo effects into clinical picture, besides that pharmacological effects full potential cannot be exploited. However, in recent decades, extraordinary advances have been made in new drug delivery systems for the encapsulation of active plant metabolites, thus helping to improve different medicinal plant-based therapies and product efficacy. The current review highlights the importance of nanocarriers loaded with plant extracts as an alternative for dental, dermatological, gastrointestinal,...
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