Posted by admin on Dec 31, 2020 in |
Sphagneticola trilobata L. has been used to treat various diseases in worldwide. This study investigated the antioxidant activity and phytochemical constituents in chloroform and ethanol extract of Sphagneticola trilobata L. The extract of Sphagneticola trilobata L. was screened for antioxidant potential through DPPH assay, FRAP radical scavenging assay and phytochemical analysis was carried out for the detection of active secondary metabolite or different constituents such as alkaloids, flavonoids, proteins, carbohydrates and phenolic compound. Different concentrations of extract were analyzed and ascorbic acid was used as a standard antioxidant. IC50 and % inhibition were evaluated. S. trilobata L. leaves extracts of methanol and chloroform was found to be highly significant with the least IC50 value ranging from 68.0 to 75.0 µg/ml in DPPH. Chloroform and methanol extracts of S. trilobata L. leaves showed excellent FRAP free radical scavenging activity with IC50 value ranging from 0.55 ± 0.042 and 0.55 ± 0.03 respectively and ascorbic acid 0.63 ± 0.01 and the extract was found to contain large amounts of secondary metabolites...
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Posted by admin on Dec 31, 2020 in |
The stem bark of Khaya senegalensis, known as mahogany is commonly sold on the Ghanaian market for the treatment of numerous ailments. To ensure its safe and efficacious use, there is a need to ensure that this plant material is of the best quality. Quality will involve ensuring its identity, purity and content are up to recommended standards by applying available and relevant methods. As a means to improve the safe use of the material, mutagenic studies were also conducted. This study sought to evaluate parameters that can be easily applied to evaluate the quality of the stem bark of K. senegalensis. Macroscopy, microscopy, physicochemical, and phytochemical investigations using fluore-scence and UV analysis were employed. Microscopic analysis of K. senegalensis leaf revealed the presence of calcium oxalate crystals, trichomes, stomata cells, and vein islets. Phytochemical screening of the stem bark showed the presence of alkaloids, saponins, tannins, flavonoids, glycosides, and terpenes. UV analysis displayed spectra that shift and change in absorbance on acidification and basification of the aqueous and...
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Posted by admin on Dec 31, 2020 in |
In recent years, scientific research has confirmed the presence of large amounts of probiotic Lactobacillus sp. in fermented dairy products, which shows a positive impact on human health. This study was designed to isolate Lactobacillus with probiotic potential from local and commercial samples. 40 Lactobacilli strained were isolated from commercial and local yogurt samples by tenfold dilution plating method and plated on Man-Rogosa-Sharp agar medium and were screened for their use as potential probiotics. The isolates were tested for their ability to survive at pH 2.0, pH 3.0, in the presence of 0.3% bile salt and antimicrobial activity; sensitivity against 10 specific antibiotics (ciprofloxacin, erythromycin, tetracycline, penicillin G, ampicillin, streptomycin, polymyxin B, vancomycin, chloramphenicol and rifampicin) using filter paper disc diffusion method and two-fold serial dilution methods. Out of the 40 strains, 24 strains (42%) had survival rates above 90% after 2 h of incubation at pH values of 2.0 or 3.0 pH. Further screening performed on the above 40 isolates indicated that 24 strains show to 0.3% bile salt. Lactobacilli...
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Posted by admin on Dec 31, 2020 in |
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAFLD progression. Several epidemiological, familial, and twin studies have elucidated the role of heritability. More recent genome-wide association studies and candidate gene studies have reported certain genes that play a key role in the susceptibility and advancement of NAFLD. The genetic basis of the disease further enhances the understanding of the pathogenic mechanism, which helps in developing novel biomarkers and therapeutic strategies. This review provides a summary of the genes involved in the susceptibility of...
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Posted by admin on Dec 31, 2020 in |
Novel Di and Tridentate chiral molecules and its analogues were designed and synthesized in that the chiral amino ester and 2-amino-3, 5-dibromobenzaldhehyde were condensed. Further, it has coupled with Cassic acid to form desired active molecules. The developed compounds are evaluated for molecular docking to check potency and may represent potential drug candidate inhibitors of RNA dependent RNA polymerase of Covid-19, compare to Remdesivir and Hydroxychloroquine. The present work is to identify and investigating the potential drug out of eight compounds that may be used to inhibit RNA-dependent RNA polymerase non-structural proteins complex of Covid-19 to prevent the replication of viral genome in host cells. The compounds BNT-202006, BNT-202008 & BNT-202009 showed and exhibited minimum binding energy when it bound with protein targets when compared with Remdesivir and Hydroxychloroquine as standard...
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