Posted by admin on Sep 30, 2022 in |
Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the medicinal herbs studied for antioxidant, antibacterial, and antifungal effects. Curcumin has been established to be defensive against nephropathy. Objective: The purpose of this study was to assess turmeric’s effect on different kidney function parameters in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Two hundred patients with T2DM were selected in randomized control trial, of which 100 subjects were enrolled in the study group, were given 500 mg of raw turmeric powder in capsule form daily along with their antidiabetic drug medication (Metformin) for 3 months period while 100 subjects on medication of antidiabetic drug (Metformin) were selected as a control group. Serum levels of urea, creatinine, total protein, albumin, and globulin were...
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Posted by admin on Sep 30, 2022 in |
Background: Cancer is one of the deadly diseases, accounting for nearly 10 million deaths every year. Cancer is one of the leading dreadful conditions which most people. Cancer is may due to genetic change, which interferes with normal growth mechanisms. A mutant cell divides and produces abnormal masses. Cancer cells can break away from the mass (or tumour) and travel via the bloodstream or lymphatic system to different body parts. These cells can settle in other body parts to form secondary cancer or metastasis. Various approaches have been introduced to eradicate cancer. Objective: In this literature, we aim to study the In-silico molecular docking for Thiadiazole derivative with an anti-tumor receptor. Methodology: We have used Argus lab software for molecular docking. Ligand is prepared using Chemsketch software and proteins are prepared using Chimera software. Main Observation: our study shows that the binding value lies between -9.7 to -7, and hydrogen bonds are formed. Conclusion: Our study concludes that the Thiadiazole derivative forms good binding affinity with chosen receptors and...
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Posted by admin on Sep 30, 2022 in |
A smile is a basic and universal facial expression and is an interaction between the teeth, the lip, and the gingival outlines. The smile plays a significant role in the communication and appearance of an individual. As the esthetic demand increases, obtaining a “perfect smile” has become a major goal for many people of this generation. One of the most important features of dental and facial aesthetics is the vertical anterior tooth display. This esthetic judgment is made by viewing the patient from the front side in dynamic states like a conversation, facial expressions, and smiling. Excess gingival display (EGD), also known as a gummy smile, is defined as a high smile line showing more than 1.5 to 2 mm of the gingiva during smiling. It is a common condition with a 2:1 female predilection. At least 50% of the population exhibit some form of gingival display in a normal smile. A gummy smile or an excess gingival display (EGD) is generally considered unattractive, while a discrepancy will always...
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Posted by admin on Sep 30, 2022 in |
To study and investigate transfersomes as a transdermal delivery system for the poorly soluble drug, Lornoxicam-loaded transfersomes were prepared with non-ionic surfactants like span 80 and tween 80 by the rotary evaporation-sonication method. Drug & polymer was dissolved in an organic solvent mixture of chloroform and ethanol (1:1, v/v). The outcome of the work is that prepared formulations were characterized for particle size analysis, drug entrapment, optical, phase contrast and transmission electron microscopy, in-vitro drug release through cellophane membrane, and drug release kinetic studies. FTIR studies showed compatibility of the drug with excipients. Based on the entrapment efficiency, drug content and in-vitro release studies, the formulation S2 containing span 80 (4% w/w) was selected for permeation studies through albino mice skin and compared with the pure lornoxicam solution. The cumulative percentage of lornoxicam permeated in all formulations was significantly (p<0.05) higher than the pure drug solution. Parameters like vesicular size, zeta potential, and drug entrapment were evaluated after one month. The study substantiated that the transfersome can be used...
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Posted by admin on Sep 30, 2021 in |
This study was aimed to evaluate the anti-diabetic activity of Ethanolic extract of the whole plant administered at different dosages (100 mg/kg and 200 mg/kg) for 21 days in Dithizone-induced diabetic rats using Glibenclamide as a standard drug (hypoglycemic drug). For the study, rats were divided into five groups of six animals each. Group, I served as control, Group II served as diabetic control received Dithizone, Group III diabetic rats were served with Glibenclamide while Group IV and V diabetic rats were received 100 mg/kg and 200 mg/kg of Ethanolic extract of Caralluma adscendens whole plant. The antidiabetic potential of the whole plant extract was undertaken in Dithizone induced hyperglycemic models by comparing biochemical parameters like blood glucose levels, OGTT and lipid profile (total cholesterol, triglycerides, LDL, and HDL), total protein and liver function tests (Total bilirubin, ASP, ALT, and AST) along with the liver antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA), glycogen content and Glycogenic enzymes were quantified using standard experimental procedures. ...
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