Posted by admin on Jun 30, 2015 in |
A rapid, sensitive and specific RP-HPLC method was developed and validated for determination of Rosuvastatin Calcium in bulk and tablet dosage form. Chromatography was carried out on a Enable C18G (250 x 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and water in the ratio of 75:25 % v/v as mobile phase at a flow rate of 0.6 ml/min and effluent was monitored at 252 nm. The method was linear over the concentration range of 5 – 40 µg/ml with a correlation coefficient of 0.999. The retention time of the drug was 3.097 mins. The proposed method was validated by determining sensitivity, accuracy, precision, robustness studies. The developed method was effectively applied to tablets of Rosuvastatin Calcium and the % assay of the drug was found to be 99.98 %. The method is simple, rapid, accurate, precise and reproducible and hence can be applied for routine quality control analysis of Rosuvastatin Calcium in pure and tablet dosage...
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Posted by admin on Jun 30, 2015 in |
The complications as well as expense had been increased in marketing new chemical entities (NCEs) due to their poor solubility, high toxicity, high dosage, non-specific delivery, in-vivo degradation and short circulating half-lives. Nanoparticles possess immense prospective as an efficient drug delivery system. Nanoparticulate-based delivery systems have potential to significantly impact on pharmaceutical industry and can make a huge impact through drug targeting because it leads to reduction in toxicity and increased efficiency of chemical entity. Nanoparticulate drug delivery system has been extensively useful in the field of pharmaceutical, because they results in controlled and sustained release properties and can decrease the gap between drug discovery and drug delivery. This review aims to summarize various production methods, attributes, drug loading, drug release pattern and pharmaceutical applications of NPs. In this review, numerous potential methods employed for fabricating NPs such as emulsification solvent evaporation method, solvent diffusion method, salting out technique, coacervation/precipitation and polymerization has been illustrated through sequential...
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Posted by admin on Jun 30, 2015 in |
Pain is the most predominantly associated symptom with patients visit to the dental office. The pain may arise due to either an endodontic cause or a periodontic cause, but the endodontic pain type variant is the most commonly encountered by the dentists in their dental offices. Even though the endodontic pain is more common, there arises a dilemma in diagnosing and planning the treatment for the patient in day to day practice. This makes the proper diagnosis and adequate management of the endodontic pain as an important part of any dental practice. This article aims to review the importance of diagnosing the cause and adequate treatment for endodontic...
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Posted by admin on Jun 30, 2015 in |
This study aims to utilize natural palm oil in the formulation of liposome and evaluate its stability and degradation via the 1H NMR technique. In this study, the conventional method was used to prepare liposome consisting 0, 5, 10, 15, 20 and 25% of palm oil in their structure, and the liposome were characterized in vitro afterwards. The chemical degradation of liposome in the presences of blood component was detected using 1H NMR after incubation period of 2 hours, one day and one week. According to 1H NMR spectrums, samples that lack palm oil or those exceeding 15% palm oil concentration underwent decomposition in the first 2 hours, while samples that were loaded with 5,10 and 15% or palm oil showed no such degradation. However, after being incubated for a day with serum component, the samples loaded with 10 and 15% palm oil remained stable and did not succumb to degradation. It can be surmised that this approach is a viable analytical concept based on the chemical characteristics and...
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Posted by admin on Jun 30, 2015 in |
A series of novel 3-(substituted aryl)-1-(5-methylfuran-2-yl)prop-2-en-1-one derivatives (3a-k) were synthesized from commercially available 2-acetyl-5-methylfuran and various substituted aromatic aldehydes in presence of anhydrous potassium carbonate in ethanol solution and by microwave irradiation method with good yield compared to conventional method. Anhydrous potassium carbonate has been utilized as safe, inexpensive and efficient basic catalyst for synthesis of chalcones. The structures of the all synthesized compounds have been established on the basis of IR, Mass, 1H NMR and 13C NMR. The antimicrobial activities of these derivatives were evaluated by quantifying the minimal inhibitory concentration (MIC) against various microbial strains such as Escherichia coli [ATCC-9637], Staphylococcus aureus [ATCC-25923], Klebsiella pneumonia [ATCC-13883], Candida albicans [ATCC-28366], Rhizopus arrhizus [ATCC-11145] and Aspegillus niger [ATCC-26036]. Among the tested compounds, compound 3h exhibited strong microbial activity against most of the microbial strains except A....
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