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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 1 (2010) - Issue 9, September

Review Articles

 
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1.

NANOSUSPENSION: AN ATTEMPT TO ENHANCE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS

Most of the new chemical entities coming out from High-throughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging ...

H Banavath, Sivarama Raju K, Md. Tahir Ansari, Md. Sajid Ali and Gurudutta Pattnaik*

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Raebareli (UP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8).1-11

1-11

2184

950

2.

TRANSGENIC ANIMALS: PRODUCTION AND APPLICATION

Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good qua...

Manmohan Singhal* and Niraj Kansara

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8).12-22

12-22

29988

7688

3.

A REVIEW ON ETHANOMEDICINAL USES AND PHYTO-PHARMACOLOGY OF ANTI-INFLAMMATORY HERB VITEX NEGUNDO

Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinocicep...

Trapti Rastogi*, Meenal Kubde, I. A. Farooqui and S. S. Khadabadi

Government College of Pharmacy, Amravati, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).23-28

23-28

3078

874

4.

PHARMACOLOGICAL SCREENING OF ANTIULCER AGENTS: A REVIEW

Gastric hyperacidity and gastro duodenal ulcer is a very common global problem today. Among various causes of gastric ulceration lesions caused by stress, alcohol consumption, H.pylori infection and use of NSAIDs have been shown to be mediated largely through the generation of reactive oxygen species (ROS), especially hydroxyl radical (*OH). Hyper secretion of gastric acid is a pathological condit...

Neetesh K Jain*, Namrata Singh, Pushpendra Kannojiya, Navneet Garud, Akanksha Garud and S D Tonpay

Department of Pharmacology, G R Medical College, Gwalior (M.P.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).29-37

29-37

3315

684

Research Articles

 
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5.

FORMULATION AND IN VITRO EVALUATION OF RAPIDLY DISINTEGRATING TABLETS OF LORATADINE

The aim of the present research work is to evaluate the impact of superdisintegrants in the formulation and evaluation of rapidly disintegrating tablets. In the present study, Loratadine is the model drug. Rapidly disintegrating tablets of Loratadine was prepared by direct compression method. In this method the different excipients used were Calcium Silicate (FM1000), Pharmattose DCl-21 (anhydrous...

Hitesh A Patel*, Jayvadan K Patel and Kalpesh N Patel

Nootan Pharmacy College, S.P.Sahkar Vidhyadham, Kamana Crossing, Visnagar, Mehsana, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).38-44

38-44

1982

953

6.

ANTI-ALLERGIC AND ANTICATALEPTIC ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF AILANTHUS EXCELSA ROXB.

The anti-allergic of an aqueous extract of the leaves of Ailanthus excelsa Roxb.(AELAq) was evaluated by using milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis in rats models while the anticataleptic properties was evaluated by Clonidine induced catalepsy in mice mode. The extract significantly (*p<0.05, **p< 0.01) decreased the leucocytosis and eosinophilia along ...

Dinesh Kumar *, Z A Bhat, P Singh, S C Mudgade, V D Bulani and S S Bhujbal

Department of Pharmaceutical sciences, University of Kashmir, Srinagar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).45-51

45-51

1379

565

7.

MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS

Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...

Vivek Kumar Sharma*, Ashok Goyal and Subrahmanya G Sarma

Department of Pharmacology, Govt. College of Pharmacy, Rohru, Shimla (HP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).52-57

52-57

1372

622

8.

PHARMACOGNOSTIC STUDIES OF POTENTIAL HERB – TRIDAX PROCUMBENS LINN.

The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax Procumbens Linn. Tridax Procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. ...

A V Zambare*, G S Chakraborthy and S K Banerjee

SVKM’s, NMiMS, School of Pharmacy & Technology Management, Shirpur (MH), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).58-62

58-62

2013

527

9.

SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATION

Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, P...

S Venkataraman*, Anitha, R Meera, P Muthumani, R Xavier Arullapa, P Devi and N Chidambaranathan

Department of Pharmaceutical Chemistry, K M College of Pharmacy, Uthangudi, Madurai, TamilNadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).63-77

63-77

1376

547

10.

EFFECT OF TRIDAX PROCUMBENS ON PROTEIN CONTENTS OF VARIOUS ORGANS IN FEMALE ALBINO RATS

The optimization of this study is biochemical effect of protein in Liver, Kidney, Uterus and Ovary of albino rats (Sprague-dawley strain) weighing about 200-250gm treated orally of ethanolic extract of plant Tridax procumbens at 300mg/kg body weight concentration for 3 and 5 days chronically. The result showed that both treated groups of rats are not showing very significant changes in protein con...

Vinita Ahirwar*, Kusum Singh, Sapna Rani, Ankita Srivastava and Tariq Gul

Department of Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi (UP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).78-81

78-81

1598

593

11.

EVALUATION OF ANTIDIABETIC ACTIVITY OF A POLYHERBAL FORMULATION IN ALLOXAN INDUCED DIABETIC RATS

Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β- cytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants l...

P. Selvam

Maharaji College of Pharmacy, Chennai (Tamil Nadu), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).82-87

82-87

1500

556

12.

EVALUATION OF ANTIFUNGAL ACTIVITY OF CALOTROPIS GIGANTEA LATEX EXTRACT: AN IN VITRO STUDY

Medicinal plants are important source of potentially useful structures for the development of novel chemotherapeutic agents. The present study was aimed to evaluate the antifungal effect of partially purified C. gigantea latex extract on some human pathogenic fungi. Ethanolic extract of the latex were tested in vitro against fungi strains. The inhibitory effect was assessed by disc diffusion metho...

Venkatesan Saratha and Sorimuthu Pillai Subramanian*

Department of Biochemistry, University of Madras Guindy campus, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).88-96

88-96

3010

1002

13.

PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF SOLANUM NIGRUM ON THE BLOOD SUGAR OF ALBINO RATS

In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Solanum nigrum (commonly called Makoi) is also a medicinal plant. A dietary intake of Solanum nigrum supplies our body with nutrients that offer protection against numerous diseases. All parts of this...

Nazoora Saleh Aali*, Kusum Singh, Md. Iqbal Khan and Sapna Rani

Department of Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi (UP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).88-96

97-99

1839

655

14.

PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS ON PTEROSPERMUM ACERIFOLIUM LEAVES

Keywords: Pterospermum acerifolium, Pharmacognosy, Sterculiaceae, Drug StandardizationPterospermum acerifolium plant is considered to be laxative, anthelmintic, stomachic and used in inflammation, blood disorders, ulcers and leprosy. The leaf was studied for pharmaconostic evaluations, including examination of morphological and microscopic characters, determination of leaf const...

Rasika D Bhalke* and Subodh C Pal

Department of Pharmacognosy, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).100-04

100-104

1476

582

15.

SYNTHESIS, ANTI-VIRAL AND CYTOTOXICITY STUDIES OF SOME NOVEL N-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

A series of novel N-substituted benzimidazole derivatives were synthesized and screened anti-viral activity against a HIV -1 and -2 in MT-4 cells. New compounds were synthesized through modifying the N-1 hydrogen of benzimidazole moiety with the substitution of sulphanilamide, sulphadimidine, sulphamethoxazole, 2-aminopyridine, pthalamide, benzamide, nicotinamide, anthranilic acid and 2- marcapto-...

Periyasamy Selvam*, Dhani Ram Lakra and Christophe Pannecouque

Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).105-09

105-109

1409

705

16.

TISSUE CHLOROQUINE LEVELS IN DIABETIC RATS

Diabetes mellitus is a disorder of metabolism resulting from insulin abnormality. Tissue levels of chloroquine in diabetes were investigated. Few diseases have such plural effects in the body as diabetes mellitus. Chloroquine distribution in the tissue and blood was investigated in diabetic rats to a certain how diabetes mellitus affects the levels of chloroquine in tissues and blood. This may pro...

Onyegbule A F, Adelusi S A and Omogbai E K I

Department of Pharmaceutical & Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka , Nigeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).110-14

110-114

1289

467

17.

ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR THE ESTIMATIONOF THYMOL IN TACHYSPERMUM AMMI MILL FRUIT BY GAS LIQUID CHROMATOGRAPHY

Thymol is the main volatile compound extracted from dried fruits of Tachyspermum ammi Mill. The compound serves as a biological marker because of its interesting biological activities and is used in traditional medicine, as a bactericide, fungicide, Gastro-intestinal disorders, Bronchitis and asthma, and others. A GC method for the determination of thymol was developed. Chromatographic analysis wa...

Chander Prakash*, S H Ansari, Gurpreet Kaur, Ilyas U K, Ishal M P, Nopa Ram and Gagan Deep Singh

Department of Pharmaceutical Sciences, Jamia Hamdard University, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).115-19

115-119

1478

596

18.

IN VITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF VETIVERIA ZIZANIOIDES ROOT

Objective: To evaluate the antibacterial activity of ethanolic extract of roots of Vetiveria zizanioides. Method: Ethanolic extract of roots of Vetiveria Zizanioides was prepared. Standard cultures of Escherichia coli NCIM 2118; Bacillus subtilis NCIM 2063, P. aeurogenosa NCIM 2036 and Staphylococcus aureus NCIM 2079 were used for the study. The antibacterial tests used were the agar well plate...

V Subhadra Devi*, K Asok Kumar, M. Uma Maheswari, A T Siva Shanmugam and R Sankar Anand

Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(9).120-24

120-124

2189

588