The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
Cranberries (Vaccinium macrocarpon) contain many bioactive compounds and have some biological activities and beneficial health properties. This study aimed to screen phytochemicals of cranberry fruits from the different solvent, to estimate the total phenolic and flavonoid content of cranberry fruits and their antioxidant effect in-vitro by DPPH, superoxide and nitric oxide radical scavenging assa...
The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) due to its low solubility and first- pass metabolism. So, nanoemulsion of nimodipine increase its solubility and enhance its oral bioavailability. Pseudo -ternary phase diagrams were made by using aqueous titration me...
COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS
In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based o...
STUDY ON THE ANTI METASTATIC AND ANTICANCER ACTIVITY OF TRITERPENE COMPOUND LUPEOL IN HUMAN LUNG CANCER
Lup-20(29)-en-3-ol, known as Lupeol is one of the most extensively studied triterpene compounds for their diverse biological properties. Natural triterpenoids gain pre-eminence in cancer research owing to their effects in regulating transcription factors and pathways associated with cell proliferation. The objective of the present study was to evaluate the anticancer activity of Lupeol on human ad...
In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have bee...
ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF LEAF EXTRACTS OF THE INDIAN TRADITIONAL MEDICINAL PLANT WRIGHTIA ARBOREA
Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents...
QUANTITATIVE ESTIMATION OF TOTAL PHENOLIC CONTENT OF TWO SPECIES OF PORTULACA OBTAINED BY USING MICROWAVE ASSISTED EXTRACTION AND ITS VALIDATION
Portulaca oleracea and Portulaca quadrifida have been used traditionally have been used for their pharmacological properties and consumed as a part of the diet. Anti-oxidative property of phytochemicals might play a role in their observed benefits, and phenolic compounds are known to be the major contributors towards the anti-oxidant property of phytochemicals. The objective of this study was to q...
DESIGN AND DEVELOPMENT OF ANTI-DIABETIC TABLET FORMULATION CONTAINING SPRAY DRIED EXTRACT OF MULBERRY LEAVES
Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia in diabetes is associated with long term damage, dysfunction, failure of kidney, nerves and blood vessel. Nowadays, herbal treatments available for diabetics are eroding the share of allopathic formulations. Cur...
IMPROVING SOLUBILITY OF CURCUMIN IN AQUEOUS SYSTEM BY THE SELF-ASSEMBLY OF HYPERBRANCHED POLY(AMIDE-ESTER) AND CURCUMIN
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Flu...