NATURAL OCCURRENCE OF MYCOFLORA AND DETERIORATION OF TOTAL ALKALOIDS AND GLYCOSIDES AMOUNTS IN STEREOSPERMUM CHELONOIDES DC. ROOTS UNDER STORAGE
In the present study, total 15 fungal species isolated from roots of drug Stereospermum chelonoides DC. such as: Fusarium solani, F. lateritum, F. semitectum, F. oxysporum, Aspergillus ochraceus, A. niger, A. terreus, Theilavia terricola, Papulaspora immerse, Scytallidium thermophilum, Didymostilbe sp., Cunningamella elegans, Aphanomyces sp., Sordaria fimicola and Mucor praini. Species of Fu...
COMPARISON OF ANTIHELMINTHIC ACTIVITY BETWEEN BISARYL BENZYL PIPERAZINE AND BENZIMIDAZOLE LINKED PIPERAZINE DERIVATIVES
Helminthes infections are more common in poor countries where people suffer from poor health hygiene and sanitation, though there are lot of marketed drugs available for these disease but the interesting thing about antihelminthics is that they are either pypirazine or benzimidazole derivatives, so as medicinal chemist the attention will be drawn towards these different moieties which exert same b...
Anticoagulants are a class of drugs commonly used to prevent the blood from forming dangerous clots that could result in a stroke.Warfarin is an oral anticoagulant. Warfarin differs from most other drugs in that the dosage required to achieve a desired therapeutic effect varies greatly among individuals. Resistance to warfarin has been described as the inability to prolong the prothrombin time or ...
STUDY OF THE EFFECT OF SODIUM VALPROATE ON ENHANCEMENT OF MONOAMINE MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of sodium valproate on enhancement of monoamines mediated behavioural responses following administration of ECS for ten days to rats. Methods: Forty rats were selected for the study in which tonic-clonic seizures were developed fully after giving single maximal electroconvulsive shock (150V, 210mA). Four groups (n= ten in each) were received dif...
Patients with DM are often afflicted by debilitating urologic complications. The main aim of this study is to investigate the effect of streptozotocin (STZ)-induced type I diabetes on contractile responses to numerous stimuli, intracellular cation concentrations and morphology in the rat. Adult rats (n=12) were humanely killed and detrusor muscles of urinary bladder located and excised rapidly a...
Aim: To evaluate anti-inflammatory effects of losartan in experimentally induced rheumatoid arthritis (RA). Materials and Methods: Adjuvant induced arthritis model is used in this study. Albino-Wistar rats of either sex were used. Arthritis was induced by single intra-plantar injection of Freund’s complete adjuvant (FCA) suspended in oil in right hind paw. Rats were divided in to three groups...
EFFECT OF VITAMIN E ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTION WITH COMMONLY USED ANTI DIABETIC AGENTS
Effect of Vit. E on blood glucose and its possible interactions with oral antidiabetic agents (i.e. glimepiride, gliclazide and metformin) in rabbits have been reported in the present study. The study was performed on albino rabbits in which hyperglycemia was induced by giving glucose. We observed that Vit.E significantly lowered the blood glucose level but on co-administration with oral antidiabe...
A MODIFIED LIQUID CHROMATOGRAPHIC METHOD DEVELPOMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE IN BULK AND TABLET DOSAGE FORM
A simple, precise, accurate, reproducible and economical reverse phase liquid chromatography method was developed and validated for the quantitative simultaneous estimation of Bisoprolol Fumarate and Hydrochlorothiazide in bulk and marketed formulations. Estimation of drugs in this combination was done with a C18 column Kromasil 100-5C18 column [250mm x 4.6mm].using mobile phase of composition A...
A study was undertaken to fractionate and characterize the antidiabetic potential of Cyperus pangorei rhizomes. The column chromatography and HPTLC study was performed on ethyl acetate fraction and five sub-fractions were separated and subjected for the evaluation of antidiabetic potential in streptozotocin induced diabetic rats. The experimental data indicated that the ethyl acetate sub-fractio...
A COMPARATIVE STUDY OF EFFECT OF INTRAVENOUS DEXMEDETOMIDINE VS. PLACEBO BEFORE BRACHIAL PLEXUS BLOCK ON PATIENT SATISFACTION AND SUCCESS OF BLOCK
The brachial plexus block(BPB) has gained importance as regional anaesthetic technique for upper limb surgery. The primary aim of our study was to evaluate the addition of intravenous dexmedetomidine before BPB on overall patient satisfaction and sucess with objective of comparing the onset and duration of block, haemodynamic stability and sedation score. A randomized double blind prospective stud...