Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
SYNTHESIS OF QUINAZOLINONE DERIVATIVES AND THEIR ANTIMICROBIAL EVALUATION
Some new series of 3-(4-substituted-phenyl)- 2-thioxo-2,3-dihydroquinazolin-4(1H)-one, 3-(4-substituted-phenyl)-2-(methylthio)quinazolin-4(3H)-one and 3-(4-substituted-phenyl)-2-hydrazinylquinazolin-4(3H)-one were synthesized by cyclization of 4-substituted-phenylcarbamodithioate with methyl anthranilate followed by reaction with dimethylsulphate and then prepared compound was refluxed with hydr...
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MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...
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ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX-2 INHIBITOR WITH CONVENTIONAL NSAIDs
Objective: The selective COX-2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due to chances of less adverse effects. So the main objective of this research work is to lower the dose of selective COX -2 inhibitor, combine with a conventional NSAID and find out t...
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ASEPTIC PROCESSING RISK MANAGEMENT: A REVIEW
Aseptic processing is a widely used technology in the field of pharmaceutical, biotech, and medical device industries for the preparation of sterile materials. The term aseptic processing as it is applied in the pharmaceutical industry refers to the assembly of sterilized components and product in a specialized clean environment. Aseptic processes are some of the most difficult processes to conduc...
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A RAPID AND SENSITIVE METHOD FOR THE QUANTITATION OF MONTELUKAST IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States - Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used...
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NANOMEDICINE: A MAGICAL HOPE FOR THE MEDICAL WORLD
Emerging nanomedicine technologies could dramatically transform medical science as we know it today with their potential to address unmet medical needs and provide targeted therapy. Nanomedicine technologies could find an increasing place in various areas and applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. The advent o...
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ANAL CANAL CANCER TREATMENT BY CONCURRENT CHEMORADIOTHERAPY VERSUS RADIOTHERAPY ALONE: A COMPARATIVE STUDY
Aim: The aim of this retrospective study is analysis of results of patient treatment outcome when prescribing chemotherapy and radiotherapy as concomitant setup as compared to radiotherapy alone for patients with anal canal carcinoma and related complications of this mode of treatment. Materials and Methods: 24 patients of anal canal cancer (squamous cell carcinoma-17 and adenocarcinoma-7)of me...
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EFFECT OF MAGNESIUM STEARATE ON MUCOADHESIVE MICROSPHERES OF REPAGLINIDE
In this study, an attempt was made to prepare Mucoadhesive microspheres of Repaglinide using various Mucoadhesive polymers designed for oral controlled release. Microspheres containing the Mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS 100, Repaglinide as a model drug and agglomeration preventing agent magnesium stearate were prepared by the Emulsification solvent eva...
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RP-HPLC METHOD FOR THE DETERMINATION OF 5-FLUROURACIL IN PHARMACEUTICAL FORMULATIONS AND SPIKED HUMAN PLASMA
A simple, rapid and accurate reverse phase high-performance liquid chromatographic method for the determination of 5-Flurouracil (5-FU) in pharmaceutical formulations and human plasma samples has been developed and validated. The assay of the drug was performed on a CLC C18 (5 μm, 25 cm 4.6 mm i.d.) with UV detection at 266 nm. The mobile phase consisted of methanol-water mixture in the ratio...
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TOXICOLOGICAL STUDY ON THE EGFR PROTEIN INHIBITOR (IRESSA 1) USING TOPKAT
The epidermal growth factor receptor (EGFR) pathway has emerged as a key target in non-small-cell lung cancer. EGFR inhibition in non-small-cell lung cancer is achieved via small molecular tyrosine kinase inhibitors, such as erlotinib or Iressa (gefitinib), or monoclonal antibodies such as cetuximab. The EGFR is under investigation as a therapeutic target for cancers. Lung cancer cell lines are va...
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