Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.87 | 4.57 | 2.15 | 1.07 | 0.58 | 0.38 |
FORMULATION AND EVALUATION OF TIZANIDINE SUSTAINED RELEASE MATRIX TABLETS USING HYDROXY PROPYL METHY CELLULOSE
Tizanidine is a muscle relaxant agent, with the half life of 2.5 hours and requires daily doses to maintain adequate plasma concentrations. The present study was undertaken to with an aim to formulation development and evaluation of Tizanidine hydrochloride sustained release tablets using hydrophilic polymer to sustain the action of Tizanidine. Different batches of Tizanidine hydrochloride were pr...
5157
2139
EARLY CO-ADMINISTRATION OF VITAMIN E ACETATE AND METHYLCOBALAMIN PREVENT PROGRESSION OF NEUROPATHIC COMPLICATION IN DIABETIC RATS
Oxidative stress has been implicated in the eiteology of diabetic neuropathy (DN) and anti-oxidants have shown to ameliorate this condition. Previous studies have indicated that early treatment with vitamin E acetate (VE) and methylcobalamin (MCA) attenuated surgery induced neuropathy in rats. The aim of this study was to test the effect of early co-administration of VE (50 mg/kg) and MCA (500µg/...
3320
1410
DEVELOPMENT AND VALIDATION OF AN UPLC METHOD FOR IN-VITRO STUDY OF GLIPIZIDE EXTENDED RELEASE TABLETS
A Reversed Phase Ultra Performance Liquid Chromatographic (RP-UPLC) method was developed for the determination of glipizide (GLI) in in-vitro study during formulation development. The chromatographic separation was achieved on a Acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 µm) column, with a mixture of 55 volumes of methanol and 45 volumes of buffer contain 0.001M sodium dihydrogen phosphate in iso...
4985
1875
A STUDY OF RELATIONSHIP BETWEEN ANTIBIOTIC RESISTANCE AND MOLECULAR CHARACTERISTICS OF ESCHERICHIA COLI ISOLATES OBTAINED FROM DIFFERENT HUMAN CLINICAL SPECIMENS AGAINST MULTIPLE ANTIBIOTIC RESISTANCE (MAR) INDEX IN BAREILLY (INDIA) REGION
To analyse the situation of antibiotic resistance, a total of 77 E. coli isolates from urine, pus, sputum and endo-tracheal aspirate were screened for their antibiograms for antibiotic resistance, multiple antibiotic resistance (MAR) index for evaluating the spread of resistance and plasmid profiles for the presence and characterization of plasmids. Very high resistance level (>90%) was detecte...
4573
1501
SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF CEFUROXIME SODIUM AND SULBACTAM SODIUM IN INJECTON
Cefuroxime is a 2nd-generation cephalosporin and Sulbactam is a β-Lactamase inhibitor. The combination formulation is used for the treatment of lower respiratory tract infection. Two new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Cefuroxime Sodium (CEF) and Sulbactam Sodium (SUL) in their combined dosage form...
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2840
STRUCTURE ELUCIDATION AND ANTIHEPATOTOXIC ACTIVITY OF CIS AND TRANS ISOMERS OF PIPERINE ISOLATED FROM DRIED FRUITS OF PIPER LONGUM
The two pure phytochemicals characterized as cis-piperine and trans-piperine isolated from the dried fruits of Piper longum were tested for antihepatotoxic activity at the dose of 50 mg/kg orally respectively, against silymarin as a standard reference. The toxicity was induced by CCl4, and then various biological parameters such as AST, ALT, ALP, SOD, GPx, GSH, total protein, total albumin and tot...
4992
1774
A NOVEL SUSTAINED RELEASE ROBUST MATRIX PELLETS OF GLIPIZIDE
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, ...
3932
2000
VISIBLE SPECTROSCOPIC DETERMINATION OF FAROPENEM SODIUM IN PHARMACEUTICAL DOSAGE FORM
Two simple, precise, accurate and economical visible spectrophotometric methods were developed for the determination of faropenem in bulk and in tablet dosage forms have been described. The method A was based on the formation of green color complex with Potassium ferri-cyanide in the presence of Ferric chloride, which show maximum absorbance (λ max) at 745nm.The method B is based on the reduction...
5442
2667
MOLECULAR DOCKING OF PHYTOCHEMICAL AS FTSZ CELL DIVISION PROTEIN INHIBITOR IN MYCOBACTERIUM TUBERCULOSIS
Mycobacterium tuberculosis is the causal agent of tuberculosis which is an infectious disease responsible for more than 2 million deaths per annum worldwide, mainly in developing countries. Cell division of this microbe is very crucial for propagation. Filamenting temperature sensitive mutant Z (FtsZ) is very important player that seems to assemble into a dynamic ring (Z- ring) on the inner surfac...
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2216
COMPARATIVE ASSESSMENT OF MILK BORNE PATHOGENS AND THEIR ANTIBACTERIAL SENSITIVITY
Milk is considered as a highly nutritious and valuable human food, consumed by the people in a variety of different products. The present work is an effort to have a survey of number of bacteria present in different milk samples viz., Raw, Boiled, Pasteurized and Skimmed milk collected from local market of Haridwar and its adjoining areas by serial dilution method and the quality of milk assessed ...
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2033