Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
COMPUTATIONAL MODELLING AND FUNCTIONAL CHARACTERIZATION OF HDAC-11
In eukaryotes, DNA is packaged into chromatin structures, whose basic unit is the nucleosome. A principle component of chromatin that plays an important role in the regulation of DNA is the modification of histones. Since histones are post-translationally modified, there inludes a large number of different histone post-translational modifications. These histone modifications create a repressive en...
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EVIDENCE FOR COMPLEX FORMATION OF IBUPROFEN WITH GO-GHRITA
Present investigation provides evidence for complex formation of Ibuprofen (Ib) with Go-Ghrita (GG). Ibuprofen binary mixture in (1:0.5), (1:1), (1:2), (1:3) w/w proportions were prepared by adding to molten Go-Ghrita kept over a water bath at 65-70oC with continuous stirring. Organoleptic and Physico-chemical properties of GG (procured from Magan Sangrahalaya, Wardha) were as per the specificat...
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SAFETY AND ADVERSE EVENTS OF PROPHYLACTIC HPV VACCINES AMONG HEALTHY WOMEN: A SYSTEMATIC REVIEW & META ANALYSIS
Cervical cancer (CaCx) is the third most common female cancer worldwide with an estimated 5, 27, 624 new cases and 2, 65, 653 deaths in 2014. We conducted a systematic review and meta- analysis to assess safety of prophylactic HPV vaccines compared against placebo. Four unique trials were included out of 607 publications. The total patient data evaluated was 1427(852 in vaccinated arm; 575 in the ...
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UPBRINGING OF CHILDREN AND ROLE OF UNANI MEDICINE IN CHILD HEALTH CARE: A REVIEW
Infancy is the most important period of human life, because a infant grows up to be a healthy teen and adult, parents should have to take precautions seriously so as to impart a healthy life to their child, since the immunity of children is not so strong as that of adults so they are prone to diseases and illnesses, the medicine used in conventional system of medicine for such pediatrics ailment...
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CARDIOPROTECTIVE EFFECT OF IVABRADINE VERSUS CARVEDILOL IN RATS
The discovery of the f-channel and its role in regulating pacemaker activity lead to the development of new pharmacological agents such as ivabradine, which target these f-channels causing a reduction in heart rate by inhibiting the /fcurrent. The aim of the present work was designed to evaluate the cardioprotective effect of ivabradine on experimentally- induced myocardial infarction and adrenali...
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EFFECT OF METOPROLOL AND ATORVASTATIN ON OXIDATIVE STRESS IN SOUTH INDIAN CARDIOVASCULAR PATIENTS
Over production of oxygen free radicals, which is mainly mediated by super oxide, occurs in human atherosclerosis. Metoprolol and atorvastatin are the drugs which found to be more prescribed drugs for cardiovascular patients. In the present study, an attempt has been made to evaluate the levels of serum Glutathione, Total anti-oxidant status, lipid peroxidation (malondialdehide) and liver funct...
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TOXICOLOGICAL EFFECT OF MALLASINDURA (MSL) ON LIVER FUNCTION PARAMETERS OF RAT PLASMA AFTER CHRONIC ADMINISTRATION
Mallasindura (MSL), a widely used ayurvedic preparation is used for the treatment of bronchial asthma. It contains rasa –mercury, Rasakarpura -mercurial compound, Bali –purified and processed sulphur and Malla-purified arsenic oxide with herbal juices. The liver function parameters of rat plasma were studied after chronic administration of MSL. The animals used to conduct this experiment wer...
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MODELING OF BAKER TRIAZINE DERIVATIVES AS DHFR INHIBITORS USING QUANTUM CHEMICAL DESCRIPTORS
DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Tri...
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ELECTROCHEMICAL BEHAVIOR AND ANALYSIS OF KETAMINE IN PHARMACEUTICAL FORMULATIONS BY VOLTAMMETRIC TECHNIQUES
The electrochemical behavior of Ketamine is studied by employing D.C. Polorography (DCP), Cyclic Voltammetry (CV) and Differential Pulse Polarography (DPP) in universal buffers of pH ranging from 2.0-12.0. The kinetic parameters, such as transfer coefficients, diffusion coefficients and heterogeneous forward rate constant values were evaluated by employing these techniques. Differential Pulse Pola...
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STUDY OF ANTIDEPRESSANT ACTIVITY OF CHRONIC ADMINISTRATION OF TRAMADOL AND WHEN IT IS CO-ADMINISTERED WITH FLUOXETINE IN LOW DOSES IN SWISS ALBINO MICE USING DESPAIR SWIM TEST
Objective- To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods- The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as...
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