SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW4-(SUBSTITUTED\ARYL)-((1, 3–DIPHENYL-1H-PYRAZOLE-4-YL) METHYLENEAMINO)-1, 5-DIMETHYL-2-PHENYLPYRAZOLILDIN-3-ONE DERIVATIVES
Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated....
ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability an...
SYNTHESIS AND CHARACTERIZATION OF NOVEL CHOLESTERYL LACTATE BASED FATTY ACID ANALOGS AND THEIR IN VITRO ANTIMICROBIAL ACTIVITY
A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with –COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C10-C18, unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyo...
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The re...
COMPARISON OF ANALGESIC EFFECT OF EPIDURAL ROPIVACAINE (0.2%) AND ROPIVACAINE (0.2%) WITH FENTANYL (4mcg/ml) IN POST OPERATIVE PATIENT OF TOTAL KNEE REPLACEMENT SURGERY
Introduction: Epidural anesthesia is the most commonly used technique for providing not only peri-operative surgical anesthesia but post-operative analgesia in lower abdominal and limb surgeries. Our study aimed to assess the comparison between ropivacaine(Group A) and combination of ropivacaine with fentanyl (Group B) in terms of their analgesic effect, hemodynamic stability, side effects and req...
Drug addiction represents one of the major medical, social, and economic burdens of human behavior. Opioids are powerful relievers; use of opioids for the treatment of pain has been associated with the potential disadvantages including development of tolerance, dependence. There are seven stages involved in opioid addiction. Identification of glial-mediated mechanism inducing opioid side effects i...
Background: In present study, we aim to assess the anticandidal activity of crude extracts and screening of bioactive compounds and their identification by NMR, IR and GC-MS. Results: A total of 192 isolates were isolated from patients having oral and vaginal candidiasis and a total of 134 isolates showed positive results with Gram staining. The selected isolates APKU-2, APKU-3 and APKU-4 were ide...
Nanosized ﬂuorescent carbon particles, carbon dots (CDs), are a kind of ﬂuorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Mor...
The objective of the study is to design gastro retentive drug delivery systems for Amoxycillin trihydrate. It was prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. The preparation was carried out by using guar gum as a carrier in the form ...
The present study was carried out to evaluate anti-tussive activity of ethyl acetate and methanolic extract of leaves of Adhatoda vasica Nees. As cough is a natural reflex expulsive defense mechanism of the body, it is the most common symptom of respiratory disease. Ammonium hydroxide and Sulphur dioxide induced cough models in mice were used for evaluation of antitussive activity of ethyl acetate...