Despite recent success, many fast-dissolving tablets (FDTs) still face problems of low mechanical strength, poor mouth-feel, higher wetting and disintegration times. This research work aimed to overcome from these drawbacks. Attempts were made to prepare fast dissolving tablets by employing vacuum drying technique utilizing single and multi-volatile components. Analysis revealed that, formulation ...
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SALBUTAMOL AND BECLOMETHASONE IN BULK AND TABLET DOSAGE FORM
A new, simple, sensitive, precise, accurate and stability indicating RP-HPLC method has been developed for the simultaneous estimation of salbutamol and beclomethasone in combined tablet dosage form. The analysis was carried out at 230 nm and this chromatographic separation was achieved with Kromasil 250 C18 [250 x 4.6 mm, 5µ] column under 25 oC temperature and using mobile phase water and aceton...
LETROZOLE AND FRUCTOSE-INDUCED POLYCYSTIC OVARIES IN THE RAT: A NOVEL MODEL EXHIBITING BOTH OVARIAN AND METABOLIC CHARACTERISTICS FOR POLYCYSTIC OVARY SYNDROME IN RAT
Introduction: There are numerous animal models available for polycystic ovary syndrome (PCOS), a fully convincing model for PCOS reflecting all pathologic condition of PCOS seen in humans is not available due to difficulties in inducing all pathologies in rat models. If so, it will help to test drug to treat PCOS. The main goal of this study is to create a new model to reflect all pathologic condi...
Cefepime is a broad - spectrum new parenteral cephalosporin used to treat moderate to severe nosocomial pneumonia, empirical treatment of febrile neutropenia and infections of the skin and urinary tract. In this present study a simple, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for analysis of cefepime powder for injectable solu...
ISOLATION AND CHARACTERIZATION OF A NOVEL ANTICANCER MUSCLE PROTEIN FROM EDIBLE MARINE CATFISH TACHYSURUS DUSSUMEIRI
Cancer, the uncontrolled growth of cells, has been estimated as a major cause of death among human population. Although there are many potential drugs, a much effective bioactive drug with less side effects are still in its pioneer stage of research. The aim of the study was to isolate, purify and characterize the anticancer muscle protein from edible marine catfish, Tachysaurus dussumieri, so as ...
SCREENING AND MOLECULAR IDENTIFICATION OF POTENTIAL EXOPOLY-SACCHARIDES (EPSs) PRODUCING MARINE BACTERIA FROM THE BHAVNAGAR COAST, GUJARAT
Marine environment is a complex habitat defined by a wide fluctuation in conditions such as pH, temperature, nutrient availability, osmotic pressure and salinity. Because of these various extreme environmental conditions, it harbors varieties of biodiversity such as bacteria, algae, fungi, coral reefs and sea weeds, as compared to terrestrial environment. For adaptation in these conditions marine ...
EFFECT OF ALOE VERA EXTRACT AND ISONIAZID – RIFAMPICIN DRUG ON LIVER HISTOLOGICAL STUDIES OF MALE WISTAR RATS
The study carried out to find the effect of Aloe vera extract on the toxicity induced by INH - RIF in male Wistar albino rats. We have perform the experiments on rats for 30 days and found the effect on histological alternations of liver by two different method. Firstly, by Compound microscopy and the same tissues were further process through SEM microscopy. We have found the effect of Aloe vera e...
FORMULATION, EVALUATION AND RADIOGRAPHIC STUDY OF STOMACH SPECIFIC FLOATING TABLETS CONTAINING VENLAFAXINE HYDROCHLORIDE FOR TREATMENT OF DEPRESSION
Depression is a chronic, recurring, and potentially life-threatening illness. The present work is to formulate floating tablets of Venlafaxine hydrochloride as this drug is used to treat depression. GIT absorption of Venlafaxine hydrochloride is poor due to low aqueous solubility. Thus, an attempt was made to enhance it gastric residence time that will improve its dissolution profile. The floating...
A COMPREHENSIVE REVIEW ON THE USEFULNESS OF TELEHEALTH INTERVENTION FOR CHILDREN WITH DISABILITY WITH SPECIAL REFERENCE TO SAUDI ARABIA
Background: Healthcare requirements have changed gradually from the primitive ages to this modern era. Information and communication technology has opened innovative techniques like home healthcare for patients through telehealth use. Aims: 1. To find out the usefulness and effectiveness of telehealth intervention on the daily living activities amongst children with disability in Saudi Arabia. 2. ...
STUDIES ON THE EFFECT OF CORE AND SURFACE CROSS-LINKING AGENTS IN PECTIN BEADS ON THE ENTRAPMENT OF INSULIN
Ionotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes and proteins, prepared by various polysaccharides. The externally cross linked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel beads by dispersing th...