THE RELATIONSHIP BETWEEN CLINICAL FEATURES AND MAGNETIC RESONANCE IMAGING PROVED LUMBAR DISC BULGING AND HERNIATION
Background: Lumbar disc herniation is one of the commonest causes of low back pain. The magnetic resonance imaging is a gold standard non-invasive investigation for viewing lumbar anatomy in detail. Aim of the Study: To evaluate the effects of body mass index on the presence, extent and severity of lumbar disc bulging and herniation as well as to determine the relationship between clinical feature...
MOLECULAR DOCKING AND TOXICITY STUDIES OF SERIES OF COMPOUNDS FROM DIARYL UREA HITS & SPIRO PIPERIDINE INDOLINYL SERIES AS POTENTIAL P2Y1 RECEPTOR ANTAGONISTS
Scientific investigations revealed that the study of P2Y1 receptors is very much essential in the current scenario because of their potential role in related to various disorders/diseases like thrombosis, cardiovascular problems. P2Y1 receptors belong to G protein-coupled receptors, an important target for ADP induced platelet aggregation. Blockade of P2Y1 receptors leads to the treatment of throm...
THE EFFECT OF DOXYCYCLINE HYDROCHLORIDE ON MMP-2 AND 9 IN EXPERIMENTALLY INDUCED PERIODONTITIS – AN ANIMAL STUDY
The periodontal tissues undergo constant changes of remodelling when subject to bacterial infection and the resultant host response. The balance between enzymes secreted by the host such as matrix metalloproteinases (MMPs) and their antagonists tissue inhibitor of metalloproteinases (TIMPs) are major contributors to the progression of periodontal destruction. A sub-type of MMPs referred to gelatin...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF MIRABEGRON IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC
This current study describes developing the novel, precise, simple analytical method suitable for determination of Mirabegron (MIRA) in a pharmaceutical dosage form. Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method was utilized for method development and validation studies of MIRA. Chromatographic separation was carried out on Agilent technologies -1260 infinity system, eclip...
A PILOT STUDY TO ASSESS THE EFFICACY AND SIDE EFFECTS OF SILYMARIN ALONE AND IN COMBINATION WITH ALENDRONATE IN TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
Background: Currently oral bisphosphonates such as alendronate are the preferred therapeutic option for the treatment of postmenopausal osteoporosis by increasing bone mineral density and decreasing both vertebral and non-vertebral fracture risk. Silymarin is mainly used as hepato-protectant but in recent studies on ovariectomized rats, it was found that silymarin can be a promising antiosteoporot...
Objective: The present work deals with the statistical optimization of memantine hydrochloride orally disintegrating tablets by the design of experimentation. The study was aimed at the development of a stable and robust formulation for the well-being of society for the treatment of Alzheimer’s disease, which is the most common form of dementia. Methods: Binder (X1), disintegrant (X2), and dilue...
IN SILICO DESIGN, DOCKING, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES
Emergence of resistant bacterial and fungal strains towards existing antimicrobial agents is one of the major motives for research and development of new molecules to defend them. Oxadiazole is a major compound of heterocyclic nucleus for the development of new drugs. Oxadiazole ring system could be incorporated into many more ring systems which itself have their own activity and could lead to pot...
The paper focuses on different marketing techniques in Pharmaceutical Industry with reference to anti-ulcer drugs. This is an industry where a number of characteristics like, efficacy, quality and safety matters while delivering a product (i.e. the drug). This study comes up with drug development and the various aspects of bringing the product to the market. Secondly, it deals with determining the...
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with ...
COMPARATIVE STUDY ON EFFECT OF OMEGA-3 FATTY ACID AND BONE MARROW MESENCHYMAL STEM CELLS ON COLD STRESS INDUCED NEURONAL CHANGES IN THE HIPPOCAMPUS OF RATS.
The present study aimed to compare the effect of Omega3 fatty acids (OFA) and bone marrow mesenchymal stem cells (BMSC’s) on stress induced neuronal degeneration in CA1 hippocampus region of rats. For isolation and culture of BMSCs, a three week old Wistar rat was sacrificed, femora and tibiae were collected then mesenchymal cells cultured. The 6th passage cells are analyzed by flow cytometry fo...