1.
Fungal infections constitute a significant global health challenge, necessitating prolonged therapeutic interventions and confronting limitations such as inadequate dermal penetration, emerging drug resistance, and systemic toxicity. Conventional topical formulations of antifungal agents often demonstrate suboptimal clinical efficacy owing to poor permeation across the stratum corneum and instabil...
Sakshi Laad and Pooja Tiwari *
IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore, Madhya Pradesh, India.
DOI: 10.13040/IJPSR.0975-8232.17(5).1355-63
1355-1363
2.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and leading cause of dementia, imposing a rapidly growing clinical and socioeconomic burden worldwide. This narrative review summarizes current understanding of AD pathophysiology, advances in diagnostics, and emerging therapeutic approaches. Hallmark mechanisms include amyloid-β plaque deposition, tau hyperphosphorylation, mi...
Virendra Kushwaha *, Pooja Agrawal, Shweta Pandey, Shivangi Raj Singh, Sonali Chandra and Shekhar Tripathi
Department of Pharmacology, G. S. V. M. Medical College, Sarvodaya Nagar, Kanpur, Uttar Pradesh, India.
DOI: 10.13040/IJPSR.0975-8232.17(5).1364-74
1364-1374
3.
The anti-aging cosmeceutical industry has transformed from conventional cosmetic applications to biologically active products designed to target the key molecular mechanisms of skin aging itself. The focus of this review is to identify key bioactive ingredients, their mechanisms of action, and delivery systems being used in anti-aging products. The most commonly used bioactives are retinoids, pept...
Ayesha Siddiqua Gazi *, Umaymah Ahmareen, Aaine Ashfaq and Mehveen Mukaram
Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad, Telangana, India.
DOI: 10.13040/IJPSR.0975-8232.17(5).1375-95
1375-1395
4.
Transdermal drug delivery system (TDDS) is an emerging modality in drug administration of skeletal muscle relaxants (SMRs), which have significant benefits in comparison to traditional oral and injectable delivery methods. Including tizanidine and baclofen, which often exhibit poor bioavailability, first-pass liver metabolism, and overall systemic adverse effects, including sedation and gastrointe...
Nisha Ballarpure, Neha Yadav and Anmol Dhawande *
School of Pharmacy, G. H. Raisoni University, Saikheda, Pandhurna, Madhya Pradesh, India.
DOI: 10.13040/IJPSR.0975-8232.17(5).1396-05
1396-1405
5.
Alzheimer's disease is a progressive neurological disorder and the main cause of dementia worldwide. It imposes a substantial socioeconomic and healthcare burden, especially as people age. This article discusses the complex pathophysiology of Alzheimer's disease, including the β-amyloid cascade, tau hyperphosphorylation, cholinergic dysfunction, excitotoxicity, oxidative stress, chronic neuroinfl...
Mann Patel *, Pankti Dalwadi and Nishit Patel
A-one Pharmacy College, Ahmedabad, Gujarat, India.
DOI: 10.13040/IJPSR.0975-8232.17(5).1406-13
1406-1413
