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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 3, March

Review Articles

 
Title
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1.

LAMININ DERIVED PEPTIDES: A PROMISING AND TISSUE-SPECIFIC APPROACH

Tissue specificity is the essential need of the hour to cut down clinical abnormalities. Allowing desired drug concentration to reach the target site is the current trend of the drug delivery system. Laminin is an active component of the basal lamina and present in most cells and organs has shown great utility in this case. It is a heterotrimeric glycoprotein containing an α-chain, a β-chain, an...

N. Afrose, P. Panja and S. Dasgupta *

Department of Pharmaceutical Science and Technology, Maulana Abul Kalam Azad University of Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1019-35

1019-1035

689

513

2.

SEASONAL FLUCTUATIONS IN ARBUSCULAR MYCORRHIZAL FUNGAL COMMUNITIES: A REVIEW

Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heav...

Chhavi Mangla, Aditya Kumar * and Ashok Aggarwal

Department of Botany, Dayanand College, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1036-43

1036-1043

381

243

3.

QUALITATIVE AND QUANTITATIVE ESTIMATION OF TYROSINE KINASE INHIBITORS IN PHARMACEUTICAL AND BIOLOGICAL MATRICES – AN OVERVIEW

Tyrosine kinase inhibitors generally having a narrow therapeutic window and large inter-patient variability. In order to support its therapeutic drug monitoring, fast and accurate methods are needed to supporting the pharmacokinetic-guided dosing in patients treating with various tyrosine kinase inhibitors (TKIs) either alone or in combination in bulk, formulations or human plasma using HPLC and d...

Srinivasa Rao Atla *, Bhagyasri Boyina and Drakshayani Badana

Department of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1044-56

1044-1056

426

382

4.

A REVIEW ON HEALTH ISSUES AND PLAUSIBLE REMEDIES IN MENTALLY CHALLENGED CHILDREN

The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex Mental health problems are characterized by in definite persistently depressed mood, low self-esteem, loss of interest in normal life activities. A common problems were the chances to occurs from generation to generation, i.e., genetic in nature, and these may a...

Ruchika Garg and Ladli Kishore *

Department of Pharmacology, Maharaja Agrasen School of Pharmacy, Maharaja Agrasen University, Baddi, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1057-64

1057-1064

364

202

5.

QUINAZOLINE HETEROCYCLE AND ITS ANTI-CANCER ACTIVITY: AN OVERVIEW

The aim of this review is to provide an extensive overview of the diverse pharmacological activities of quinazoline moiety. Quinazolines are well-known and important nitrogen-containing heterocyclic compounds made chemical formula C8H6N2. For the last few years, the heterocyclic fused nucleus quinazoline has drawn immense attention due to its diversified application in medicinal chemistry research...

Neil B. Panchal

Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1065-78

1065-1078

455

247

6.

RATIONAL APPROACHES FOR SYNTHESIS OF SOME NOVEL IMIDAZOLE HETEROCYCLES WITH THEIR BROAD SPECTRUM OF PHARMACOLOGICAL ACTIVITIES: A BRIEF REVIEW

Imidazole has a special role in heterocyclic chemistry, and its derivatives have piqued interest in recent years due to its diverse chemistry and pharmacology properties. Imidazole is a nitrogen-containing heterocyclic ring that is essential in biology and pharmaceuticals. As a result, imidazole compounds have piqued the attention of researchers for more than a decade. Thus imidazole compounds hav...

Nilesh S. Pendbhaje *, Rutuja D. Bankar, Abolee S. Bramhankar, Rupali V. Nirmal and Ashwini A. Jamdhade

Head of Department, Diploma in Pharmacy, SRE’S, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1079-85

1079-1085

202

121

7.

BIOLOGICS AND BIOSIMILARS- A MEDICINE FROM THE LIFE AND FOR THE LIFE: THE COMPLETE REVIEW

In this review, we are completely discussing different eras in pharmaceutical drugs/medicines, i.e., Biologics and biosimilars. These biologics can be called life drugs because they are deriving from living organisms, microbes, yeast, bacteria, and human blood products. These biologics are biopharmaceutical products that are derived from living organisms and are very complex in molecular structure...

Syam Sundar Reddy Onteddula and Gopinathan Narasimhan *

Department of Pharmaceutical Chemistry, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai , Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1086-98

1086-1098

200

114

Research Articles

 
Title
Views
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Cited
8.

VALIDATION THROUGH RE-DOCKING, CROSS-DOCKING AND LIGAND ENRICHMENT IN VARIOUS WELL-RESOLUTED MAO-B RECEPTORS

Molecular docking is one of the most utilized in silico techniques, which drastically reduces the cost and the time needed for the design of novel drugs. Recently, the tremendous growth of resolved crystallographic MAO-B structures, together with the rapidly rising computing power, has resulted in accelerated and moderately correct docking studies. However, initial validations of the docking proto...

Emilio Mateev *, Iva Valkova, Borislav Angelov, Maya Georgieva and Alexander Zlatkov

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav str., 1000 Sofia, Bulgaria.

DOI: 10.13040/IJPSR.0975-8232.13(3).1099-07

1099-1107

691

293

9.

PREDICTION OF HOTSPOT IN PROTEIN-PROTEIN/PROTEIN-SUBSTRATE INTERACTION: A NOVEL COMPUTATIONAL APPROACH

Protein-protein, as well as protein-substrate interactions, play an important role in regulating specific biological functions like signal transduction, apoptosis, gene regulation, and immune response. These play a major role in drug discovery applications and can be used as molecular targets to stop disease development at the molecular level. Thus, understanding the biological mechanism of protei...

Kiran T. Raj, Ankita Singh, Naveen Kulkarni and T. S. Gopenath *

Department of Biotechnology & Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1108-19

1108-1119

326

170

10.

HPLC METHOD FOR ESTIMATION OF VALTRATE IN VALERIANA JATAMANSI AND VALERIANA PYROLAEFOLIA

Valtrate is one of the major valepotriates reported from various species of the genus Valeriana. Aim of the present study was to develop and validate analytical method for quantification of valtrate in dried roots of Valeriana jatamansi and Valeriana pyrolaefolia, both members of family Valerianaceae. Acetonitrile and water (70:30) in isocratic mode were used with an aflow rate of 1.5 mL/min (at 2...

Ashwani Kumar *, Maninder Karan and Karan Vasisht

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1120-24

1120-1124

411

203

11.

ANTIBACTERIAL ACTIVITY OF SOME COMMON KITCHEN SPICES AGAINST ESCHERICHIA COLI, STAPHYLOCOCCUS AUREUS, SALMONELLA TYPHIAND PSEUDOMONAS AERUGINOS

The current study investigated and compared the antibacterial activity of common kitchen spices; Ginger, Turmeric, Bay leaf, and Coriander, against Escherichia coli, Staphylococcus aureus, Salmonella Typhi, and Pseudomonas aeruginosa. The antibacterial activity of different spices was calculated by the agar well cup plate method. The concentrations, 75%, 50%, and 25%, were made for all the test sp...

Raman Yadav *, Shivchandra Kumar Yadav, Sushmita Soni and Siyaram Bhagat Mali

Department of Pharmacology *, SRMC & RI, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1125-34

1125-1134

446

286

12.

STABILITY INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF ACEBROPHYLLINE AND DOXOFYLLINE IN PHARMACEUTICAL DOSAGE FORM

Objective: To develop a simple, selective, and precise stability-indicating high-performance liquid chromatography method for the simultaneous estimation of acebrophylline and doxofylline in bulk and tablet dosage form. Methods: The chromatographic separation achieved on HiQSil C18 Column (250 × 4.6 mm, 5µm) utilizing a mobile phase Acetonitrile: 10 mM n-hexane sulfonic acid buffer (80: 20, v/v)...

Ram S. Sakhare *, Sanjay S. Pekamwar and Narendra Gangadharrao Patre

Department of Quality Assurance, Channabasweshwar Pharmacy College (Degree), Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1135-42

1135-1142

385

267

13.

DEVELOPMENT AND EVALUATION OF POMALIDOMIDE SUPERSATURABLE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVED SOLUBILITY AND DISSOLUTION RATE

Background: Pomalidomide belongs to BCS class IV drug with low solubility and undergoes first-pass metabolism leads to reduced bioavailability of 15%. Objective: The current study aimed to develop pomalidomide Super saturable-SNEDDS to enhance solubility. Methods: Preliminary solubility studies were performed to identify oil, surfactant, and co-surfactant ratios. Pseudo tertiary phase diagram cons...

Maddela Chandra Shekhar * and Pamu Sandhya

Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1143-55

1143-1155

216

148

14.

THE EFFECT OF FRACTIONS OF INDIGOFERA ASPALATHOIDES LEAF EXTRACT ON EXTEND OF LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN DMBA INDUCED HAMSTER BUCCAL POUCH CARCINOMA.

Oral cancer is the sixth leading cancer globally and the leading carcinoma in the Indian subcontinent. The relatively high incidence is due to usage of tobacco, and exposure to carcinogens are frontrunners of oxidative stress-induced DNA damage. The practice of chemopreventive agents is considered to be alternative oral carcinoma. A study on novel natural chemo preventive agent-Indigofera Aspalath...

Philips Abraha, Sachu Philip * and S. Sethupathy

Department of Biochemistry, Vivekanandha Dental College For Women, Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1156-62

1156-1162

174

100

15.

NOVEL IN-SITU GEL TO PROVIDE SUSTAIN RELEASE DRUG DELIVERY FOR OCULAR FUNGAL KERATITIS

Ocular deliveries possess a challenging pharmaceutical approach due to poor absorption index through the corneal appendages and washing away of the drug through tears and lachrymal secretion. The ocular appendages lead to provide lesser bioavailability of conventional dosage forms; hence, frequent dosing is advised to get the optimum effect of the medicine. Therefore, in-situ gel offers a promisin...

A. Patel *, A. Sapariya and R. Dayaramani

Department of Pharmaceutics, Khyati College of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1163-69

1163-1169

230

132

16.

FORMULATION AND EVALUATION OF HEPARIN MICRONEEDLE TRANSDERMAL PATCH

There is an urgent need to replace the injection currently used for low molecular weight heparin (LMWH) multi-dose therapy with a non-invasive delivery device. In this study, unsaturated polyester resin and peroxide were used to fabricate microneedle mould by using 3M microneedle. Dissolving microneedle arrays transdermal patch was prepared by using 20 % w/v polymers of PVA and PVP (polyvinyl alco...

A. Bhuvaneshwaran and Grace Rathnam *

Department of Pharmaceutics, C. L. Baid Metha College of Pharmacy, OMR, Thoraipakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1170-78

1170-1178

329

188

17.

IN-VITRO AND IN-VIVO EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF CALOTROPIS PROCERA ROOT EXTRACTS OF CALOTROPIS PROCERA

Objective: The Calotropis procera (Ait.) R.Br. (Ascelpidaeaceae) has been used traditionally as anthelmintic, depurative, diaphoretic, emetic, expectorant, febrifuge, and purgative, but no scientific reports are available in the regulation of asthmatic condition. In this present study, Calotropis procera (Ait.)  R.Br. was selected to investigate scientifically to establish scientific data for its...

Ankita Beniwal and Roopal Mittal *

IKG Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1179-88

1179-1188

222

136

18.

ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF BARK OF HARDWICKIA BINATA ROXB (FABACEAE / CAESALPINIACEAE)

Background and Objectives: This study was carried out with the objective to investigate the antibacterial and antifungal activity of the bark of Hardwickia binata Roxb. Materials and Methods: Methanolic extract of bark of Hardwickia binata Roxb. exhibited an inhibitory effect towards the pathogenic organisms. Antimicrobial activity the zone of inhibition values of methanolic extract of bark of Har...

Md. Rageeb Md. Usman and Rohini Patil

Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1189-93

1189-1193

183

106

19.

DEVELOPMENT AND EVALUATION OF CYCLODEXTRIN BASED NANOSPONGE LOADED TAZORETENE GEL

The objective of the present study was to develop cyclodextrin-based nanosponge based topical gel of tazoretene using cross-linker diphenylcarbonate and Carbopol® Ultrez 10 NF polymer. The β-Cyclodextrin nanosponges were prepared using various concentrations of β-Cyclodextrin and diphenyl carbonate and characterized. Based on evaluation parameters the β-Cyclodextrin nanosponges formulations (N...

P. Anitha * and B. Ramesh

Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1194-07

1194-1207

207

145

20.

EFFECT OF POLYMERIC RATIO AND PORE FORMERS ON SUPER POROUS HYDROGEL OF AMOXYCILLIN TRIHYDRATE

The work aimed to prepare super porous hydrogels (SPHs) of Amoxicillin trihydrate to release the drug in a sustained manner in the gastric environment and study the polymeric ratio and pore effect formers on the physicomechanical properties and drug release kinetics of the formulations. Fourier Transform Infra-Red (FTIR) studies were done to check the compatibility of the drug with the polymers. T...

Sayantan Bhattacharya *, Gopa Roy Biswas and Sutapa Biswas Majee

Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, 124 B L Saha Road, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1208-17

1208-1217

187

111

21.

ISOLATION, CHARACTERIZATION AND EVALUATION OF ANTI-ULCER ACTIVITY OF PHYTOCONSTITUENTS PRESENT IN MORINGA OLEIFERA LEAF

Moringa oleifera leaf is widely used in the traditional medicine system and also used as a food by different communities and local tribes of Assam in India. Moringa oleifera leaf contains various bioactive compounds such as alkaloids, flavonoids, rutin, steroids, etc. The flavonoids quercetin act as an anti-ulcer agent, and rutin have a gastro cytoprotective effect i.e., present in M. oleifera lea...

Banik Bapan *, Mallik Ajanta, Barman Priyanka and K. Das Malay

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1218-24

1218-1224

195

117

22.

DEVELOPMENT AND VALIDATION OF A SENSITIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD FOR THE ESTIMATION OF CURCUMIN IN RAT PLASMA

Curcumin is used as a potent anti-inflammatory agent in the treatment of rheumatoid arthritis and its clinical pharmacokinetics requires a sensitive method for estimation of its plasma concentration. Hence the aim of the study was to develop a rapid, selective, and sensitive HPLC method coupled with UV detection for the determination of Curcumin in rat plasma. The process of elution was carried ou...

Ayesha Syed and V. Kusum Devi *

Department of Pharmaceutics, Nitte College of Pharmaceutical Sciences, Yelahanka, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1225-30

1225-1230

180

120

23.

FORMULATION AND EVALUATION OF ACECLOFENAC MATRIX TABLETS USING SOLID DISPERSED PRODUCT

Aceclofenac is a non-steroidal anti-inflammatory drug indicated for symptomatic treatment of pain and inflammation. Aceclofenac is a BCS Class II drug with low solubility and high permeability, thus solid dispersion is one of the promising techniques used for enhancement of solubility and dissolution rate. The intent of the present study was to formulate and evaluate aceclofenac matrix tablets by ...

Revati Dharampal Sagare * and Udaykumar B. Bolmal

Department of Pharmaceutics, KLE College of Pharmacy, Vidyanagar, Hubli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1231-40

1231-1240

220

157

24.

PALBOCICLIB LOADED SOLID LIPID NANOPARTICLES BY BOX-BEHNKEN DESIGN: SOLUBILITY ENHANCEMENT

The purpose of the present study was to optimize palbociclib-loaded solid lipid nanoparticles (SLNs) by evaluating the relationship between design factors and experimental data. A three-factor, three-level Box-Behnken design (BBD) was used for the optimization procedure, choosing the amount of tricapric, cremophor RH40 and soy lecithin, as independent variables. The chosen dependent variables were...

Baji Hussain Khan and P. Sandhya *

Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1241-50

1241-1250

229

153

25.

FORMULATION AND EVALUATION OF SATRANIDAZOLE BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

Background: Satranidazole is a class II drug per biopharmaceutical classification systems with poor aqueous solubility and antiprotozoal and anti-bacterial properties. Aim: Therefore, the purpose of the present study was to enhance the solubility of Satranidazole using a self-emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Satranidazole (10 mg) and dissolved in the oil p...

Preeti Narayana Sable *, Sawroop R. Lahoti and Shyam Vishwanaath Ghadlinge

Department of Pharmaceutics Atshribhagwan College of Pharmacy, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1251-58

1251-1258

177

119

26.

ASSOCIATION OF LEVELS OF VITAMIN-D AND MANNOSE-BINDING LECTIN IN CASES OF DENGUE FEVER IN RURAL INDIA

Background: Dengue is an arthropod-borne viral disease caused by the dengue virus (DENV). DENV is an RNA virus that belongs to the Flavivirus genus. The incidence of dengue has grown in the recent decade globally. The World Health Organization (WHO) considers dengue as a major global public health challenge in the tropic and sub-tropic nations. Materials and Methods: NS1 antigen and IgM antibody E...

V. Yadav, R. K. Verma, D. P. Singh, R. Rawat and S. Saraswat *

Department of Microbiology, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, Etawah, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1259-66

1259-1266

183

136

27.

PREPARATION AND STANDARDISATION OF PANCHA HARITHAKADI CHURNA BY HPTLC

Standardization of herbal formulation is essential to assess the quality of drugs for its therapeutic efficacy. Pancha Haritha kadi Churna (PHC) is a traditional poly herbal formulation meant for digestion which consists of five ingredients having digestive property. It is used for the treatment of Constipation and Bloating. Churna’s will play an important role in gastro intestinal problems and ...

S. Srikakulapu *, C. Duraipandian and G. Venkatachalam

Department of Pharmacognosy, Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1267-70

1267-1270

202

111

28.

EARLY TREATMENT WITH PREDNISOLONE AND ACYCLOVIR IN SARS-COV-2 COMPLICATED BELL’S PALSY: A CASE REPORT

Bell's palsy is an idiopathic, unilateral, acute weakness of the face in a pattern consistent with peripheral facial nerve dysfunction and may be partial or complete, occurring with equal frequency on either side of the face. The incidence is about 20 in 100,000 people a year, with about 1 in 60-lifetime risks. Bell's palsy has a peak incidence between the ages of 15 and 40 years. Viral infections...

J. Anusha, P. Deepak, R. M. Suresh and V. Karthik *

Department of Pharmacology, Hassan Institute of Medical Sciences, Haasan, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1271-73

1271-1273

459

121

29.

DEVELOPMENT OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF DORAVIRINE: SOLUBILITY AND DISSOLUTION RATE IMPROVEMENT

Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and dissolution of poorly water-soluble doravirine. The solubility of doravirinein various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants wer...

Komala Devender Reddy * and Pamu Sandhya

Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1274-84

1274-1284

192

243

30.

STUDY ON THE ACCEPTABILITY AND FUNCTIONAL PROPERTIES OF MILLETS INCORPORATED FRYUMS

Millets are called nutri-cereals, highly nutritious, and are known to have high nutrient content, which includes protein, essential fatty acids, dietary fiber, B-Vitamins, minerals such as calcium, iron, zinc, potassium, and magnesium. They help render health benefits like reducing blood sugar level (diabetes), blood pressure regulation, thyroid, cardiovascular and celiac diseases. The present stu...

H. Upasana Sirigeri, B. M. Veena and P. Vanitha Reddy

Department of Nutrition & Dietetics-FLS, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1285-90

1285-1290

168

118

31.

DESIGN AND CHARACTERIZATION OF TASTE MASKED DEXTROMETHORPHAN HBR ORAL DISINTEGRATING TABLET BY USING NATURAL SUPERDISINTEGRANTS

Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the mic...

Shivangi Singh *, Abid Malik and Navneet Verma

Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1291-03

1291-1303

227

147

32.

IMPROVEMENT OF POMALIDOMIDE SOLUBILITY BY SOLID LIPID NANOPARTICLES BY DESIGN OF EXPERIMENT

The aim of the present work is to develop and optimize solid lipid nanoparticles (SLNs) of pomalidomide with the aid of Box-Behnken design (BBD). A design space with three formulation variables at three levels was evaluated in BBD. Amount of lipid (A), surfactant (B), and co-surfactant (C) were selected as independent variables, whereas particle size (Y1), entrapment efficiency (Y2), and percentag...

K. Someshwar * and B. Ramesh

Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1304-14

1304-1314

167

120

33.

DEVIATION IN WHO CORE PRESCRIBING INDICATORS AMONG SURGICAL PATIENTS IN SECONDARY CARE HOSPITAL: THE NEED FOR RATIONAL PRESCRIBING

Irrational use of medicines is a major problem worldwide. In surgical patients, a greater number of drugs are prescribed So, evaluating prescribing patterns of various medications in surgical inpatients would enable identifying the presence of irrational use, thereby paving a way to rational prescribing. A prospective observational study was conducted in a secondary care hospital for six months. T...

Abhirami Azad, Maria Joseph, Minnu J. Biju and Meby Susan Mathew *

Department of Pharmacy Practice, Muvattupuzha, Ernakulam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1315-21

1315-1321

189

116

34.

ANTIOXIDANT EFFICACY OF GARLIC DERIVED ALLICIN ON CULTURED BREAST CANCER CELL LINES

The present study aims at analyzing the efficiency of allicin, agarlic derived phytochemical or neutraceutical in elevating the activities of various enzymic antioxidants on its treatment to cultured breast cancer cell lines. In the experimental work, cultured breast cancer cell lines were treated with different doses of allicin, and through standardized protocols, the cell lines were assayed for ...

Anubha Chaudhari * and Rajendra Chauhan

Department of Zoology, Government MLB Girls PG Autonomous College, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1322-31

1322-1331

240

120

35.

ASSESSMENT OF METHODS USED BY REGISTERED PHARMACISTS FOR DISPOSING OF THE PHARMACEUTICAL WASTE AND EXPIRED MEDICINES AT COMMUNITY PHARMACIES IN URBAN AREA

Introduction: The use of improper disposal methods for expired medicine is an emerging issue that is affecting the ecosystem, and misuse of expired medicines is potentially hazardous for public safety. Our study was aimed to assess the methods used by the registered pharmacist for disposing of the expired medicines in community pharmacies. Materials and Methods: A questionnaire-based cross-section...

Divya Bandu Hagawane *, Narendra Bheemraj Parihar and Seeta Narendra Parihar

Department of Clinical Pharmacy, PES Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).1332-37

1332-1337

247

104

36.

STUDIES ON SOLID DISPERSION OF CURCUMIN USING HYDROPHILIC POLYMER WITH SYLOID XDP AND LOZENGE CHARACTERIZATION

Curcumin, an active phytochemical compound of the rhizome Curcuma longa, shows several pharmacological activities. Curcumin shows high permeability and low dissolution rate, and its incomplete absorption leads to very poor oral bioavailability. The present study aimed to enhance curcumin's solubility and dissolution rate by forming internal ternary solid dispersion using hydrophilic polymer PVP K3...

Pradnya Palekar Shanbhag *, Supriya Lande and Saima Shaikh

Department of Pharmaceutics, Oriental College of Pharmacy, Sector No. 2, Plot No. 3, 4, 5, Sanpada West, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1338-43

1338-1343

271

112

37.

A COMPARATIVE ANIMAL STUDY OF ANALGESIC EFFECTS OF TRANDOLAPRIL AND NIMODIPINE IN MICE USING EDDY’S HOT PLATE

Angiotensin II from the renin-angiotensin system is proposed to be pro-inflammatory induces reactive oxygen species, nuclear factor kappa B. It sensitizes pain receptors to mediators of pain (via PGE2). ACEI block these actions increase endogenous opioids by inhibiting enzyme enkephalinase. Voltage-gated calcium channels (VGCC) causing calcium influx are involved in exocytosis of synaptic vesicle ...

Sayed Shakita Fatima, P. Katiyar *, T. Kumar, Rishi Pal, R. Nath, A. Singh, D. A. Rizvi, A. K. Sachan and R. K. Dixit

University Institute of Health Sciences, C. S. J. M. University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1344-48

1344-1348

178

96

38.

PHYSICO CHEMICAL AND ELEMENTAL ANALYS IS OF THE WHOLE PLANT POWDER OF AZOLLA MICROPHYLLA

Introduction: Anabaena azollae (AM) is used as a biofertilizer feed for cattle; much research is developing toward identifying the elements and their role in food supplements for human consumption. Objective: The study was to characterize the whole plant powder of the A. microphylla concerning physicochemical and elemental analysis. Material and Methods: The whole plant powder was subjected to phy...

P. K. M. Anu Geetham * and A. Malarvizhi

Department of Biochemistry, D. G. G. Arts College, Mayiladuthurai, Nagapattinam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1349-54

1349-1354

189

96

39.

EVALUATION OF POLYGONUM GLABRUM WILLD. LEAF EXTRACTS FOR ANTIOXIDANT PROPERTY

Polygonum glabrum, commonly called dense flower knotweed, is a perennial plant found in most parts of India. The leaves of plants Polygonum glabrum Willd. Belonging to the family, Polygonaceae are a rich source of flavonoids and tannins but not yet scientifically investigated for antioxidant activity. The present study aimed to offer a novel scientific background to the leaves of Polygonum glabrum...

Kusum S. Akki *, Rahul R. Lavhale, Pratiksha Akki and R. V. Karadi

Department of Pharmacognosy, K. L. E. S. College of Pharmacy, Vidyanagar, Hubli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1355-63

1355-1363

189

190

40.

EVALUATION AND ASSESSMENT OF ADVERSE DRUG REACTIONS DEVELOPED USING NEWLY PRESCRIBED DRUGS IN PATIENTS WITH ACUTE DISEASE

The objective of current research is to assess the type of Adverse Drug Reactions (ADR) and associated risk factors, assess the prevalence, estimate the incidence of serious and fatal ADR and the severity of ADRs based on data collected from patients with ADRs caused by drug initially prescribed. Data of patients with acute diseases were collected and analyzed using SAS version 9.1. About 252 ADRs...

P. Praveen * and M. Nagulu

Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1364-73

1364-1373

170

122

41.

UV-SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF HYDROXYCHLOROQUINE SULFATE AND NITAZOXANIDE IN SYNTHETIC MIXTURE

A simple, accurate, precise, reproducible, economical UV spectrophotometric method has been developed and validated for simultaneous estimation of Hydroxychloroquine sulfate (HCQ) and Nitazoxanide (NTZ) in a synthetic mixture. Method A by simultaneous equation method, Method B by the first-order derivative method. Method A: simultaneous equation method was based on the measurement of absorbance of...

Mahyavanshi S. Aayushi * and Jasmina S. Surati

Department of Pharmaceutical Quality Assurance, Shree Lal Bhai Patel college of Pharmacy, Bardoli, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1374-82

1374-1382

241

130

42.

HEAVY METAL CONTENTS AND ASSOCIATED HEALTH RISK OF SOME GHANAIAN AND ASIAN HERBAL DRUGS

This study looked at heavy metal levels in selected registered herbal drugs of Asian and unregistered Ghanaian herbal drugs sold in Kumasi. It examined the health risks of the metals. It provided authorities with data to ensure that herbal drugs are strictly monitored and their metal levels evaluated to safeguard patrons' health. Dry ashing method was used on 10g of each of the herbal drug samples...

Kofi Sarpong, Emmanuel Agyapong Asare *, Emmanuel Dartey, Emmanuel Effah-Yeboah and Gadafi Iddrisu Balali

Department of Chemistry Education, College of Agriculture Education, Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development, Mampong-Ashanti, Ghana.

DOI: 10.13040/IJPSR.0975-8232.13(3).1383-92

1383-1392

176

99

43.

PHARMACOGNOSTIC STUDIES OF GREWIA TILIAEFOLIA VAHL

The study was designed to study the macroscopic, microscopic, and also physicochemical parameters such as fluorescence analysis, extractive values, ash values, and loss on drying were performed. Therefore, this parameter is essentially used to control the quality of crude drugs and/or herbal drugs/drug products. The moisture content (% LOD) of the leaf powder was found to be 5.10± 0.14 (% w/w), t...

Dharmasoth Rama Devi *, Ganga Rao Battu and Keloth Basavaiah

Department of Pharmacognosy and Phytochemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1393-00

1393-1400

167

135

44.

OBSERVATIONS ON CARDIAC ABNORMALITIES IN PATIENTS WITH DEXTROCARDIA AND SITUS AMBIGUUS: A RETROSPECTIVE STUDY

Studies on dextrocardia have been limited by low numbers. Hence, finding the most common diagnosis in patients with dextrocardia and situs ambiguus is challenging among patients seeking medical attention in a tertiary care center. Aims and objectives: To identify the most common diagnostic pattern in dextrocardia (DC) patients with situs ambiguous (SA). Methods: It is a retrospective study with re...

S. Tripathi *, V. K. Ajit Kumar, U. K. Pandey and D. Jain

Department of Cardiology, Institute of Medical Sciences, Benaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(3).1401-10

1401-1410

159

97