Volume 14 (2023) - Issue 6, June
Review Articles
A SYSTEMATIC REVIEW OF DIFFERENT ANALYTICAL METHODS FOR MAJOR PHYTOCONSTITUENTS OF TURMERIC AND BLACK PEPPER
Curcumin is a phytochemical isolated from Curcuma longa (Zingiberaceae) and has been used by ancient people for a long time to treat various ailments. Piperine is the main bioactive constituent that has been isolated from Piper nigrum L. Piperine increases the bioavailability of curcumin. Several analytical methods have been developed for the detection of curcumin and Piperine like high-Performanc...
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A REVIEW ON THE APPROPRIATENESS OF SURGICAL PROPHYLAXIS IN OBSTETRICS AND GYNAECOLOGY
AIM: This review aims to analyze the appropriateness of surgical antimicrobial prophylaxis in obstetrics and gynecology from 2015 to June 2022. Methodology: The review includes interventional, prospective and retrospective observational studies and surveys based on compliance with surgical antibiotic prophylaxis use concerning standard surgical antimicrobial prophylaxis (SAP) guidelines for gyneco...
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A SYSTEMATIC REVIEW ON THE SCAVENGING AND ELUCIDATING EFFICACY OF BACOPA MONNIERI AS A THYROID STIMULANT
In Indian and Chinese medicine, the herb Bacopa monnieri, (Neer Brahmi) has long been used to treat a wide range of illnesses. Brahmi offers a wide range of pharmacological advantages, including improving memory in the treatment of schizophrenia and Alzheimer's disease. The effectiveness of Brahmi in scavenging and illuminating as well as comprehensive analyses based on its pharmacological effects...
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A REVIEW OF THE MUTUALISTIC RELATIONSHIP OF ENDOPHYTIC FUNGI FOR THE PRODUCTION OF BIOACTIVE METABOLITES
Endophytes constitute a remarkably multifarious group of microorganisms ubiquitous in plants and maintain an imperceptible association with their hosts for at least a part of their life cycle. Their enormous biological diversity, coupled with their capability to biosynthesize bioactive secondary metabolites, has provided the impetus for a number of investigations on endophytes. There is a need to ...
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IMPACT OF GENETICS IN NEURODEVELOPMENTAL DISORDERS
A category of illnesses known as neurodevelopmental disorders is predominantly linked to neurodevelopmental dysfunctions. The two most prevalent neurodevelopmental disorders, “Attention Deficit/Hyperactivity Disorders (ADHD)” as well as“Autism Spectrum Disorders (ASD)”, affect both humans and lower-class species like rats, mice and zebra fish. The purpose of this review is to identify the ...
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PHARMACOLOGICAL EFFECTS OF VITIS VINIFERA SUBSP. VINIFERA: A REVIEW
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grapes are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins, in addition to abundant quantities of gal...
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PUTATIVE ROLE OF ISATIN DERIVATIVES SYNTHESIS AND THEIR BIOLOGICAL APPLICATIONS- A REVIEW
Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 first discovered isatin in 1840 as an oxidation product of indigo dye for nitric acid and chromic acid. Isatin is one of the most important heterocyclic compounds. For example, Schiff foundations of isatin are used for the...
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REGULATORY GUIDANCE FOR EMERGENCY AUTHORIZATION, EXPORT AND IMPORT OF COVID-19 VACCINES IN INDIA AND USA
This research primarily focuses on the process and impact of marketing authorizations, import, and export of COVID-19 vaccines in India and the United States. Pharmaceutical firms now have great legal grounds in India and the United States for vaccine manufacture and distribution. In this pandemic, the regulatory authority of India CDSCO and the US FDA updated the guidelines to provide approval fo...
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UPCOMING TRENDS OF PHARMACEUTICAL MANUFACTURING SCIENCES
The global pharmaceutical sector is in vital need of both Innovative technology for solutions and basic science, allowing the production of highly engineered drug products. Commercial-level manufacturing of Complex drug delivery systems utilizing current technologies is challenging. Work within the pharmaceutical trade has been restricted for an extended time to the analysis and development of the...
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NEURODEGENERATIVE DISORDERS: ROLE OF MEDICINAL PLANTS IN TREATMENT
Neurons are the nervous system's basic components that involve the spinal cord and brain. Neurons do not usually replicate or substitute them because the body cannot replace them as they get impaired or die. Neurological conditions are untreatable and disabling diseases that result in irreversible deterioration/death of the human brain's nerve cells or neurons. Treating these conditions with exten...
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A COMPREHENSIVE REVIEW OF ANTIMICROBIALS AND NOVEL OPPORTUNITIES BY TRADITIONAL MEDICINE TO REVERSE ANTIBIOTIC RESISTANCE
An Antibiotic is an infectious disease that is the chief source for treating bacterial & fungal infections. The microbial resistance problem has been increasing daily, and the viewpoint for the usage of antimicrobial drugs is still undefined. Antimicrobial-resistant organisms are found in people, animals, food, plants, and in the environment. Do not use antibiotics to treat viral infections li...
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A REVIEW ON MANAGEMENT OF CARDIOVASCULAR DISEASES BY HERBAL NANOPARTICLES
Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD’s is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globa...
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A COMPREHENSIVE REVELATION ON PISONIA GRANDIS R. BR.
Medicinal plants are a huge treasure for mankind and a source of remedy for all illnesses as they are storehouses of bio-actives. The therapeutic efficiency of formulations and medicines depends on using standardized plant extracts, as The World Health Organization emphasized. The present documentation on the medicinal plant Pisonia grandis covers its pharmacological, phytochemical, biological sta...
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MEDICINAL VALUE OF MILLETS FOR HEALTHY LIFE
Millets are one of the oldest foods known to humans and possibly the first cereal grain to be used for domestic purposes. The Indian flatbread roti is made from ground millet seeds. In malice of all these extraordinary rates and capacities of millet husbandry systems, the area under millet products has been shrinking over the last five decades and swiftly after the green revolution period. The bit...
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ADVANCEMENT, EXPLORATION AND OUTLOOK OF THE BURGEONED COVID 19 VACCINE – AN OVERARCHING RECAPITULATION
The new Covid-19 virus has reported deaths of around 1 million within about half a year. It has also led to high financial and social crises worldwide. Recent research has been performed to identify suitable treatment procedures. Steps have been taken to develop complicated, costly, and time-consuming vaccines. Viruses are highly potential to develop into perilous diseases. Over 165 vaccines were ...
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PHARMACOLOGICAL OPTIONS FOR MANAGEMENT OF COVID-19: ISSUES CONCERNING ETHICS AND RATIONAL MEDICINE USE
Coronavirus disease 2019 (COVID-19) pandemic has emerged as a major healthcare problem and has posed a great challenge to our existing healthcare facilities. Treatment of COVID-19 has been primarily based on repurposed drugs, drugs approved under emergency authorization or other options which are not thoroughly evaluated in patients with COVID-19, hence, lacking an adequate data on safety and effi...
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A COMPREHENSIVE REVIEW OF SYNTHESIS, DOCKING TARGETS AND PHARMACOLOGICAL ACTIVITIES OF PYRAZOLINE DERIVATIVES
Pyrazolines, among the various 5-membered heterocyclic compound derivatives, have drawn attention towards it because of their various pharmacologic activities. They are nitrogenous heterocyclic compounds containing two nitrogens in the adjacent position, which possess considerable biological activity. The synthesis of pyrazolines was initiated after the pioneering work of Fischer and Knoevenagel i...
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AN OVERVIEW OF TUBERCULOSIS AND MODE OF ACTION OF ANTI-TUBERCULAR DRUGS WITH THEIR APPLICATION
Tuberculosis is a very serious infectious disease that can lead to death if the person does not take medicine on time. This disease can be spread easily, but it is not mandatory that tuberculosis bacteria will attack suddenly. Still, when the immunity decreases for other reasons, then it will be an attack on health. Before this century, tuberculosis was known as a non-treated disease, but now most...
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A COMPREHENSIVE REVIEW OF THE MEDICINAL PLANT PASSIFLORA FOETIDA LINN
Passiflora foetida, commonly known as stinking passion flower has been used as traditional medicine in treating diseases such as throat infection, giddiness, liver disorder, diarrhea, tumor, nervous disorder, anxiety; sleep disorders, skin infections, hysteria and asthma. In addition, P. foetida has been reported to have potential antioxidant, anti-inflammatory, antiepileptic, anti hyperglycemic, ...
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FOCUSING ON THE RECENT PROGRESS IN ANTIMICROBIAL POTENTIALS OF PLANT EXTRACTS-MEDIATED SYNTHESIZED SILVER NANOPARTICLES
Using plant extracts to synthesize metal nanoparticles is one of the easiest, most convenient, cost-effective, and ecologically acceptable ways of avoiding hazardous chemicals. As a result, many environmentally acceptable methods for the fast production of silver nanoparticles utilizing aqueous extracts of plant components such as leaves, bark, and roots have been described in recent years. This s...
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Research Articles
ELLAGITANNIN EXTRACTED FROM PLANT EUPHORBIA PROSTRATA CLAIM MEMORY ENHANCING ACTIVITY
Human memory can store and recall previously learned information to be applied for the routine purpose. Memory disorders caused by diseases can have an impact on an individual's quality of life as well as their overall cognitive abilities. Memory disorders are associated with the alteration in cholinergic neurotransmission. The herbal extract of Euphorbia prostrata was found to be used traditional...
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DESIGN, DEVELOPMENT AND EVALUATION OF STABLE VALSARTAN NANOCRYSTALS WITH CHITOSAN USING MICROWAVE-ASSISTED GRINDING NANOTECHNOLOGY
Solubility and stability are the limiting steps for almost all drugs in the pharmaceutical field toward bioavailability. In the present investigation, microwave reacts with the crystallization solvent to change their crystalline state to stable and highly soluble nanocrystals. Microwave Assisted Grinding Nanotechnology (MAGN) was used to prepare stable nanocrystals of Valsartan, BCS class II, by t...
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IN-SILICO STUDY OF ARYL SULPHONAMIDES AS 5-HT6 SEROTONIN LIGAND: A 2D QSAR STUDY USING TOPOLOGICAL DESCRIPTORS
Serotonin plays a crucial role in various cognitive and behavioral functions. The serotonin signaling is mediated by binding of serotonin to specific receptors on the cell surface. Serotonin 5-HT6 receptors turned out to be promising biological targets for the modulation of central nervous system dysfunctions. Several classes of serotonin 5-HT6 receptor ligands have been discovered. Among them, ma...
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EVALUATION OF ANTILIPIDEMIC POTENTIALS OF PHASEOLUS VULGARIS ON ALLOXAN-INDUCED DIABETIC RATS
Healthy diet has been known to play a key role in managing and preventing diseases. The health benefits of consuming common beans (Phaseolus vulgaris) are widely acknowledged and are ascribed mostly to their high dietary fiber contents and polyphenols. Various animal experimental studies have shown that polyphenol in common beans has antioxidant properties and other biological activities. This stu...
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DESIGN AND DEVELOPMENT OF MODIFIED RELEASE TABLET BY MIXED SOLVENCY ASSISTED SOLID DISPERSION OF VALSARTAN
In the present investigation, newly developed solid dispersion technology that precludes the use of organic solvent and decreases the individual concentration of hydrotropic agents, simultaneously decreasing their toxic potential, was employed for preparing dispersions of valsartan. Valsartan is a pro-drug which has poor bioavailability because of poor solubility as it belongs to BCS class II. Stu...
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PREPARATION, CHARACTERIZATION AND EVALUATION OF RESVERATROL-LOADED PEGYLATED PLGA NANOPARTICLES
This study focuses on preparing and evaluating polymeric nanoparticles made of pegylated PLGA. In this study, both double-emulsion solvent evaporation and single-emulsion solvent evaporation were employed to formulate the pegylated PLGA nanoparticles with PVA as the surfactant. For the encapsulation of the hydrophobic drug Resveratrol, formulations were successfully prepared and tested for their p...
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IN-VITRO ANTIVIRAL ACTIVITY OF TIRYAQE WABAI AGAINST HERPES SIMPLEX VIRUS-1
Background: Herpes simplex virus (HSV) are one of the most important viruses that causes a variety of life-threatening diseases in humans and the chemotherapeutic agents available for HSV infections are limited in efficiency. The formulation from Unani system of medicine was taken for antiviral assay which has already been established as anti-oxidants, immuno-modulator, anti-inflammatory activity ...
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ANTIBACTERIAL ACTIVITY FROM DIFFERENT PARTS OF MORINGA OLEIFERA (L.) AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
Antibacterial activity of methanolic extracts of different parts (leaves, flowers, green pods and roots) of Moringa oleifera plant were evaluated against gram positive bacteria Bacillus subtilis (Bs), Staphylococcus aureus (Sa) and gram negative bacteria Klebsiella pneumonia (Kp), Escherichia coli (Ec), Pseudomonas aeruginosa (Pa). The activities were performed by the agar well diffusion and cup p...
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IDENTIFICATION AND VALIDATION OF PALUSTRIC ACID AND ANDROGRAPHOLIDE FROM OCIMUM BASILICUM LEAF AS A PROMISING BREAST CANCER INHIBITOR: AN IN-VITRO AND IN-SILICO ANALYSIS
This study aimed at identifying promising breast cancer inhibitors through in-vitro and in-silico studies. Ocimum basilicum. L is a traditional herb used for varied ailments. The present study is designed to evaluate the anti-carcinogenic potency of Palustric acid and Andrographolide against the MCF-7 cell line by in-vitro analysis. Further in-silico examination was performed to detect and formula...
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SYNTHESIS, CHARACTERIZATION, AND ANTIOXIDANT ACTIVITY OF NEW PYRAZOLES
Pyrazole and its derivatives are pharmacologically active and are being used in various disorders and diseases with a few side effects. The wide distribution of pyrazole compounds in nature with fascinating pharmacological action is key in the application of this development of newer derivatives. The main structure has a great variety of compounds that have essential pharmaceutical and agrochemica...
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CHANGES IN ASCORBIC ACID CONTENT IN SUGARCANE AFFECTED WITH POKKAH BOENG DISEASE CAUSED BY FUSARIUM MONILIFORME SHOLDEN
India, being a mega-diverse country, has extensively cultivated sugarcane (Saccharum officinarum) family Gramineae (Poaceae) from ancient to modern times. More than sixty percent of total cane area in the India is in the sub-tropics regions of the country. Gangetic plain of Uttar Pradesh has a fertile area which is highly suitable for agriculture, especially sugarcane cultivation. Sugarcane's pro...
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QBD APPROACH IN GACP FOR THE CONTROL OF AFLATOXINS IN COLLECTION AND STORAGE OF ABELMOSCHUS MOSCHATUS SEEDS & TO IDENTIFY AFLATOXINS USING HPLC-FLD TECHNIQUE
The Cultivation of Abelmoschus moschatus plants for collecting seeds used for medicinal purposes is affected by Mycotoxins which are substances that moulds create under particular environmental circumstances. These pollutants harm both human and animal health. Mycotoxins are difficult to get rid of and are occasionally impossible. The best control is prevention. Controlling the moisture levels in ...
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VALIDATED STABILITY-INDICATING RP-UHPLC METHOD FOR THE ESTIMATION OF SOFALCONE IN DRUGS, RECONCILING MASS BALANCE IN FORCE DEGRADATION STUDIES AND LC-MS IDENTIFICATION OF ITS DEGRADATION PRODUCTS
A highly sensitive, simple, accurate and precise Ultra high-performance liquid chromatographic (UHPLC) method was developed and validated for the quantitative determination of sofalcone in the presence of its degradation products. The analysis was performed on Agilent symmetry analytical column Eclipse plus C18 (100mm × 2.1 mm, 1.8μm) ultra-performance liquid chromato-graphy-Diode Array Detector...
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COMPUTATIONAL DESIGN, SYNTHESIS AND IN-VITRO EVALUATION OF NOVEL ARYL FLUORO HYDRAZIDE DERIVATIVES
Infectious diseases continue to be a major cause of morbidity and mortality, and the current antimicrobial resistance crisis has the potential to worsen this problem. To address this issue, new antimicrobials and strategies for fighting antimicrobial resistance are needed. In this study, we synthesized two arylflouro hydrazide derivatives by reacting various selected hydrazides (4-Fluorobenz-hydra...
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QBD APPROACH FOR THE DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF FORMOTEROL FUMARATE AND ACLIDINIUM BROMIDE IN PRESSURIZED METER DOSE INHALER
A Quality design approach to method development involves method goal identification, method scouting and evaluation, method selection, and risk assessment. The present study describes the risk-based HPLC method development and validation of Formoterol fumarate and Aclidinium bromide in a pharmaceutical dosage form. The chromatographic conditions were optimized with the Design Expert software 11.0 ...
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SCREENING OF AQUATIC FUNGI FOR ANTIMICROBIAL AND AMYLASE EFFICACY ISOLATED FROM FISH CULTURING PONDS OF SOUTH-EAST COASTAL ANDHRA PRADESH, INDIA
Objectives: The main intention of the current study was to isolate, antimicrobial assay and amylase screening of fungal strains SAPB-15 and SAPB-20 isolated from freshwater fish culturing ponds of Kaikaluru and Mudinepalli villages, South-East coast of Andhra Pradesh, India. Methods: The water samples were collected from different fish culturing aquatic ponds and transported to the laboratory. A s...
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COMPARATIVE EFFICACY OF SAFOOF E MUHAZZIL AND ITS COMPRESSED TABLETS ON PARAMETERS OF WEIGHT REDUCTION
Background: To enhance patient compatibility Safoof e Muhazzil (powder) was compressed into tablets. Objectives: The present study was aimed at comparing the two dosage forms for any variations in the efficacy of Safoof e Muhazzil. Method: This triple-armed RCT was carried out on 90 patients after obtaining ethical clearance and written and informed consent. The study period was six weeks. Improve...
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POTENTIAL OF PLECTRANTHUS AMBOINICUS AND OCIMUM SANCTUM PHYTOCONSTITUENTS AS ANTIVIRAL AGENTS AGAINST SARS-COV-2: AN IN-SILICO INVESTIGATION
Background: The infectious disease, COVID-19, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is hardly showing signs of waning as it is still ongoing as a pandemic. Objective: To figure out potential leads from Ocimum sanctum and Plectranthus amboinicus’s phytoconstituents against SARS-CoV-2. Methodology: Selected phytoconstituents of O. sanctum and P. amboinicus were ta...
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AN INTELLIGENT ASSISTANT FOR PREDICTION POST-COVID SKIN ALLERGIES DIAGNOSIS
The epidemic of COVID-19 provides various issues for healthcare professionals. Rapid assessment and treatment, vulnerability classification, efficient use of critical care facilities, adequate medications, surveillance, and prompt discharge, are crucial to protect as many casualties as possible. We described different classification techniques of ML (machine learning) to analyze skin-related iss...
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EVULSIONS SPECTROPHOTOMETRIC DETERMINATION OF CYCLOSERINE IN PHARMACEUTICAL FORMULATIONS WITH BPB AND BCG DYES
Two simple and sensitive evulsions spectrophotometric methods have been described for the assay of Cycloserine either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion - pair complexes of the drug with bromophenol blue (BPB) and bromo cresol green (BCG) in acidic medium. For two methods, the extracted complexes showed abs...
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MEDICINAL PLANTS USED IN RICE BEER STARTER CULTURE BY DIFFERENT TRIBES IN ASSAM: AN ETHNOBOTANICAL SURVEY
The study represents the ethnobotanical information of the medicinal plants used by the six major communities of Assam, namely Mishing, Deori, Ahom, Tiwa, Bodo and Rabha, for better understanding of their local beliefs, customs, and tradition in the preparation of traditional rice beer starter culture. A semi-structured questionnaire was used focusing on the local names of the plants used in a sta...
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COMPARATIVE SOLUBILITY STUDY OF CYCLODEXTRINS (Β- CD AND HPΒ- CD) AND ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF LORNOXICAM BY USING TERNARY COMPLEXATION
The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by Comparative solubility of cyclodextrins with Lornoxicam (LXM) by forming ternary Inclusion complexation (TIC). The phase-solubility and saturation solubility studies were executed in the existence of β-CD, HP-βCD and polymers. The drug/CD complexes were formulated and characterized furthe...
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EVALUATION OF ANTIULCER ACTIVITY OF SAPONIN-RICH FRACTION OF MORUS ALBA LEAVES
A peptic ulcer is an excoriated area of the stomach or intestinal mucosa caused principally by the digestive action of gastric juice or small upper intestinal secretions. A peptic ulcer is a conglomerate of heterogeneous disorders that manifests as a lesion in the lining of the gastrointestinal mucosa bathed by acid and pepsin. Peptic ulcers frequently occur along the lesser curvature of the antra...
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NARINGENIN THERAPEUTICS EXERT A PROTECTIVE EFFECT AND ALLEVIATE HYPERGLYCEMIA-INDUCED OXIDATIVE STRESS AND APOPTOSIS IN CARDIAC AND NEURONAL TISSUES OF BALB/C DIABETIC MICE
The continuous search to search for a naturally occurring medicinal compound that could be a suitable adjunct to existing therapies for treating one of the growing global health emergencies in diabetes is a never-ending one. Naringenin [2, 3-dihydro-5, 7-dihydroxy- 2 -(4-hydroxyphenyl) -4H-1-benzopyran-4-one], a naturally occurring flavonoid abundantly present in grapes, grapefruit, and citrus fru...
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MOLECULAR CHARACTERIZATION OF ESBL AND COLISTIN RESISTANCE GENES AMONG CLINICAL ISOLATES OF GRAM-NEGATIVE BACTERIA IN A TERTIARY HOSPITAL IN ABAKALIKI, NIGERIA
Antimicrobial resistance is a threat to public health. This study investigated the occurrence of ESBL and colistin resistance among Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa recovered from clinical samples (n=500) in a tertiary teaching hospital in Abakaliki, Nigeria. The samples were bacteriologically analyzed using selective culture media, biochemical tests, and PCR. All...
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EXTRACTION ISOLATION CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF AEGLE MARMELOS FOR ANTIASTHMATIC ACTIVITY
Aegle marmelos (L) Correa also known as Bale, belongs to family Rutaceae. The plant is used to treat several diseases like bronchitis, asthma, malarial, astringent, laxatives, digestive and febrifuge. Leaves are used as antipyretic, antimicrobial, antidiabetic, antihistaminic, anti-inflammatory, antioxidant, and hyperlipidaemic activity. The plant contains diterpenoids, triterpenoids, and phenolic...
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FORMULATION AND EVALUATION OF HERBAL ANTIOXIDANT GEL
Introduction: Herbal drugs have great growth potential in the global market. Natural product research continues to explore traditional medicines to develop new novel drugs. The present study aimed to investigate antioxidant potential of gel formulated with Punica granatum peel extract, Glycyrrhiza glabra root extract and Citrus sinensis peel extract. Method and Materials: Different gels were formu...
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QUALITY STANDARDIZATION OF AYURVEDIC FORMULATIONS – SANSHAMANI VATI AND MAHALAXMIVILAS RASA
Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the...
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EVALUATION OF ANTIDIABETIC, ANTIOXIDANT, AND PHYTOCHEMICAL ANALYSIS OF CEREUS JAMACARU D.C. SEED EXTRACT
Central and eastern Brazil is home to the cactus species Cereus jamacaru, also called mandacaru or cardeiro. It frequently reaches a height of 6 metres. For animal feed, a kind without thorns is utilized. The most typical type is quite thorny; however, if the thorns are The native Brazilian cactus Cereus jamacaru D.C., also known as "mandacaru," grows naturally in the Caatinga biome and is charact...
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STANDARDIZATION OF AMUKKARA CHOORANUM- SIDDHA DRUG
Siddha medicine originated from Tamil culture in southern India. Worldwide there are 75% of herbal plants are used for AYUSH and Allopathy medicines. Amukkara Choornam is a polyherbal Siddha formulation. Amukkara Choornam has anti-arthritic activity, and it helps to cure rheumatoid arthritis. The demand for Siddha medicines in India is increasing daily; we have to overcome some problems like quali...
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STANDARDIZATION & PHARMACOLOGICAL EVALUATION OF POLYHERBAL EXTRACT TO REPORT THE ANTICARCINOGENIC POTENTIAL
The relevance of traditional medicines and their folkloric applications for the well-being of humanity have been highlighted in the current study. To generate the polyherbal extract for the in-vitro assessment of anticancer activity, the researcher has investigated the standardization criteria for the individual plant drug and extract obtained from these herbs. According to the literature and earl...
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DEVELOPMENT AND EVALUATION OF MICROBEADS OF SIMVASTATIN LOADED WITH SODIUM ALGINATE AND ALOE VERA
Simvastatin, a lipid-lowering agent, belongs class-II drug of BCS. It has a short biological half-life (3hr), and high first-pass metabolism. The target of the present study was to prepare the microbeads of Simvastatin to provide control release of the drug with enhanced bioavailability through sustained release. The method adopted to prepare Simvastatin loaded microbeads was by the ionic gelation...
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COGNITION ENHANCING ABILITY OF A POPULAR GREEN LEAFY VEGETABLE- CHENOPODIUM ALBUM: IN-VITRO AND IN-VIVO CORROBORATION
Oxidative stress and cholinergic deficit are major culprits of cognitive impairment. Intake of green leafy vegetables - rich in antioxidant phytoconstituents- strongly correlates with memory-preserving capacity. Our earlier work showed that hydromethanol (HM) extract of Chenopodium album (a common leafy vegetable) had strong acetylcholinesterase inhibitory and antioxidant activity in-vitro. The ob...
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EXPLORATION OF ANTI-ATHEROSCLEROTIC ACTIVITY OF ORIGANUM MAJORANA L. IN EXPERIMENTAL ANIMALS WITH HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS
Atherosclerosis is a chronic inflammatory disease that is marked by atheroma and patchy intimal plaques in arteries that cause thickening and hardening of arteries. It is reported that “Origanum majorana L.” possess antiulcerogenic, antiproliferative, antioxidant, and anticarcinogenic activities, and it is an important remedy against thromboembolic disease. The present study was designed for t...
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COMPARATIVE STUDY OF PHYSICO-CHEMICAL AND PHYTOCHEMICAL SCREENING OF SOME SELECTED ANTIDIABETIC MEDICINAL PLANT
The present paper deals with the investigation of comparative physicochemical and phytochemical screening of five medicinal plants viz., leaves of Gymnema sylvestre, fruits of Momordica charantia, rhizomes of Curcum alonga, seeds of Eugenia jambolana and fruits of Embilica officinalis widely used in the treatment of diabetes. In the present communication, comparative results were shown. Various ma...
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FORMULATION DEVELOPMENT OF PVP-BASED SOLID DISPERSION OF LUMEFANTRINE WITH PIPERINE FOR SOLUBILITY ENHANCEMENT
The oral bioavailability of lumefantrine (LUMF) is low and erratic owing to its low aqueous solubility and P-glycoprotein (P-gp) mediated efflux. The present investigation aims to develop amorphous solid dispersions (SD) of LUMF co-loaded with piperine (PIP), a P-gp and CYP3A4 inhibitor, to improve its dissolution and thereby oral bioavailability. LUMF-SDs were prepared by using Polyvinyl-pyrrolid...
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GC-MS ANALYSIS AND IN-SILICO ADMET ANALYSIS OF THE AQUEOUS METHANOL LEAF EXTRACT OF ISODON TERNIFOLIUS (D. DON) KUDO
Medicinal plants contain phytocompounds which are of medicinal value. Scientific evaluation of these compounds that may serve as potential drugs is important in validating the medicinal plants. The leaf extract of the medicinal plant, Isodon ternifolius (D. Don) Kudo was prepared by the maceration method using 80% aqueous methanol as the extraction solvent. The resulting extract was subjected to ...
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EFFECTS OF OPTIMIZATION OF NUTRITIONAL REQUIREMENTS AND INFLUENCE OF ENVIRONMENTAL PARAMETERS ON BIOSURFACTANTS DERIVED FROM MARINE BACTERIA
In the present study, biosurfactant-producing microorganisms such as KM1 (Bacillus licheniformis - Kasemedu 1), KM2 (Bacillus subtilis - Kasemedu 2), ER1 (Pseudomonas aeruginosa - Ennore site 1), ER1B (Pseudomonas mendocina - Ennore site 1) and ER9 (Streptococcus lactis - Ennore site 2) were subjected to optimization studies. The optimization study was carried out using various carbon, nitrogen so...
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DOCKING STUDY OF FLT3 RECEPTOR WITH TYROSINE KINASE FOR LEUKEMIA DISEASE
Leukemia is a disease of cancer that affects blood-forming tissues i.e., bone marrow and lymph nodes, which is associated with uncontrolled growth of WBCs. These cells are unable to fight against infection and weaken the ability of bone marrow to make RBCs and platelets. When leukemic cells overproduce, they interfere in circulatory cells' functioning, i.e., RBCs and platelets. Along this, leukemi...
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PRELIMINARY STUDY OF ANTIMICROBIAL ACTIVITY AND PHENOTYPIC CHARACTER FROM ACTINOMYCETES AND PENICILLIUM SP
Indeed, Actinomycetes and Penicillium are microorganisms that live in different ecosystems. Besides, they play important roles in various fields in respect such as agriculture, medicine and the environment. During this study, we were interested in the isolation of two strains namely: Actinomycetes and Penicillium sp. from coconuts and truffle respectively. In addition, the agar cylinder technique ...
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