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ANTIOXIDANT ACTIVITY OF ISOLATED FLAVONOIDS FROM THE LEAVES OF CORCHORUS AESTUANS LINN.
Preliminary phytochemical investigation of various extracts of leaves of Corchorus aestuans Linn showed the presence of flavonoids, carbohydrates, saponins, phytosterols, phenolic compounds, triterpenoids, cardiac glycosides and tannins. An attempt has been made to isolate flavonoids and perform antioxidant potential of the same. The antioxidant activity was performed by two in-vitro testing metho...
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EXTRACTION AND PHYTOCHEMICAL SCREENING OF MIKANIA SCANDENS LINN. AND EVALUATION OF ITS METHANOLIC EXTRACT FOR ANALGESIC ACTIVITY
Mikania scandens is a rapidly growing herbaceous to semi-woody, perennial vine. It grows quickly over other plants such as young trees, smothering them; it can climb trees up to 25 m tall. Although not as serious a weed as M. chordate, in Southeast Asia it has become a hard to eradicate weed of tea, rubber, and other plantation crops. It also reduces the carrying capacity of pasture. The achenes a...
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MOLECULAR DOCKING STUDIES OF THE COMPOUNDS FROM PERGULARIA DAEMIA AND TERMINALIA CATAPPA L. LEAF EXTRACTS WITH CYP2E1,GST,UDP-GLUCURONYL TRANSFERASE AND Nrf2 BINDING SITE IN KEAP1, IL-6
Objective: Pergularia daemia and Terminalia catappa L.. Leaf extracted with hydroethanol and the extracts were separated by silica gel column chromatography. The selected column fractions are used in GC-MS analysis, from the GC-MS results eight phytochemical compounds are selected based on their biological activities. In the present work we predict the interaction of the selected targeted protei...
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STUDY OF PHYTO CHEMICAL, ANALGESIC AND ANTI ULCER ACTIVITY OF EXTRACTS OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM LINN.
The dried aerial parts of Cardiospermum halicacabum Linn were subjected to extraction using the solvents (petroleum ether, chloroform, Ethyl acetate and ethanol) in increasing order of polarity. The prepared extracts were then subjected to preliminary phytochemical analysis. It was found plant possesses carbohydrates, alkaloids, sterols, flavanoids and saponins. All extracts were selected for furt...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2′-HYDROXY-3′-NITRO-5′-METHYLPHENYL)-5-(ARYL/HETERYL) PYRAZOLES
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2'-hydroxy-3'-nitro-...
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ANTI-DIABETIC, HYPOLIPIDEMIC AND HEPATO-RENAL PROTECTIVE EFFECT OF A NOVEL FERMENTED BEVERAGE FROM SYZYGIUM CUMINI STEM
In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemi...
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SCHIFF BASES DERIVED FROM 2-HYDROXY AND 2- METHOXY NAPHTHALDEHYDE: EXPLORATION OF IN SILICO DOCKING, DNA CLEAVAGE, ANTIBACTERIAL ACTIVITIES AND SAR
Antibacterial activities, molecular docking and DNA cleavage activities of five structurally related Schiff bases [L3 (a), L3 (b), L3 (c) L3 (d) and L3 (e)] were performed and their structure activity relationship was studied. Antibacterial activities of these compounds against gram-negative and gram-positive bacteria were evaluated by using well diffusion method and the compound L3 (c); 1-[(E)-(4...
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STUDY ON SAFETY AND EFFICACY OF DIFFERENT MODALITIES IN THE POST-OPERATIVE PAIN MANAGEMENT IN A TERTIARY CARE TEACHING HOSPITAL
ABSTRACT: Background: Postoperative pain control is an important part of effective postoperative care. However, 30 - 80% of postoperative patients complain about moderate to severe post-surgical pain as a result of the surgical procedure or a pre-existing disease. Aim: To assess the safety and efficacy of different modalities of postoperative pain management in post surgical wards of a tertiary ca...
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NEW SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TOLTERODINE IN BULK AND PHARMACEUTICAL FORMULATION
Simple, fast and economic spectrophotometric methods were developed for determination of Tolterodine in bulk and pharmaceutical dosage forms using water as the solvent. The quantitative determination of the drug was carried out using the zero order derivative measured at 281.5 nm, first order derivative measured at 274 nm and area under curve was measured in wavelength range of 276-286 nm. Calibra...
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DEVELOPMENT AND IN VITRO EVALUATION OF ONCE DAILY CARBAMAZEPINE MATRIX TABLET FROM HYDROPHILIC POLYMERS
The purpose of study was to develop and characterize once daily extended release matrix tablets of Carbamazepine (CBZ), an antiepileptic drug. Tablets were prepared by wet granulation method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in fourteen formulations. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compre...
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