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PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF SODIUM VALPROATE
Mucoadhesive microcapsules of sodium valproate, an anticonvulsant used in the treatment of epilepsy and in migraine, have been prepared from sodium alginate, hydroxypropylmethyl cellulose-K4M, carbopol 934P & sodium CMC using 10% w/v calcium chloride solution by ionic gelation method. Drug: polymer ratios were 1:1 in all the formulations and polymer mixtures employed were 4:1, 5:1, 6:1, 7:1 ...
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QUALITY OF LIFE OF DIABETIC PATIENTS ON DIFFERENT TYPES OF ANTIDIABETIC MEDICATIONS
Diabetes mellitus (DM) was found to impair all dimensions of health except mental health and pain and in a more recent multinational study, DM was found to have a notable impact on general health, measured using the Medical Outcomes Short-Form 36 (SF-36). A cross-sectional, randomized study conducted in Ajman and Sharjah, October 2012 to May 2013, using a self-completed questionnaire and SF-36 h...
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PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL IN WESTERN ODISHA
Objective: To assess the pattern of adverse drug reactions (ADRs) in a tertiary care hospital. Materials and methods: This study was conducted in VSS Medical College, Burla, Odisha from October 2012 to September 2014. ADRs collected from various clinical departments were compiled and analyzed for distribution of age, gender, department, drug class and organ system. Assessment of causality, severit...
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Cu (II) METAL COMPLEXES OF SCHIFF BASES, PREPARATION, CHARACTERISATION AND BIOLOGICAL ACTIVITY
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance d...
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SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF HYDROPHILIC AND LIPOPHILIC DRUGS
Improvement in the bioavailability of poorly soluble drugs is one of the challenges faced in the formulation development of the drugs. One of the most admirable and viable formulation approaches for this is self micro emulsifying drug delivery system (SMEDDS). A combination of clarithromycin and amoxicillin has been proved effective for treatment of H. pylori which are available only in tablet dos...
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1827
CAFFEINE AND P-ANISALDEHYDE FROM THE FRUITS OF ENTEROLOBIUM SAMAN PRAIN
Fruits of the plant were air dried for several days and cut into small pieces, which were subjected to oven dried for 24 hours at 45-50°C to effect further chopping. Cold methanol extract of fruits were subjected to acid-base treatment to separate the alkaloids. The treated extract was subjected to column chromatography to isolate the pure compound. The xanthine alkaloid, 1, 3, 7-trimethyl-1H-pur...
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DRUG USE EVALUATION OF SHENMAI INJECTION IN THE FIRST AFFILIATED HOSPITAL OF BENGBU MEDICAL COLLEGE: A PROSPECTIVE ANALYSIS
Introduction: To investigate the evaluation pattern of Traditional Chinese medicine injection, establish the drug use evaluation(DUE) standards of shenmai injection, and implement of DUE programs of shenmai injection in the First Affiliated Hospital of Bengbu Medical College. Methods: Three hundred and thirty four patients were included in this retrospective analysis. The study duration was divide...
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ANTI-OXIDANT POTENTIAL OF METHANOLIC EXTRACT OF TRIGONELLA FOENUM, TRACHYSPERMUM COPTICUM, NIGELLA SATIVA AND THEIR COMBINATION IN 1:1:1 RATIO
Trigonella foenum (T. foenum), Trachyspermum copticum (T. copticum) and Nigella sativa (N. sativa) are important medicinal plants that need to be explored for their anti-oxidant potential. The aim of the present study was to evaluate the total anti-oxidant potential of methanolic extracts of T. foenum, T. copticum, N. sativa and the combination of these methanolic extracts in 1:1:1 ratio (Combinat...
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1609
BIOCHEMICAL STUDIES ON THE MICE HEART REGARDING LEAD ACETATE INDUCED OXIDATIVE STRESS
Lead is important heavy metal and due to widespread use in industry, it has become an important pollutant that exerts toxic effects on human health. Lifestyle factors (e.g. cigarette smoking), proximity to industrial areas, lead mines, lead based paints and leaded gasoline significantly contribute to lead pollution of the air, food, water and soil. Several antioxidant enzymes and molecules have be...
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SYNTHESIS OF 3- (1 – BENZYL – 1H – BENZO [D] IMIDAZOL – 2 – L AMINO) – 2 – (3 – ARYL – 1- PHENYL – 1H – PYRAZOL – 4 – YL) THIAZOLIDIN – 4- ONES AND THEIR ANTIMICROBIAL ACTIVITIES
Reaction of 1- (1- benzyl- 1H- benzo [d] imidazol- 2- yl) hydrazine (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff bases (3a-f). Further, cyclization of compounds 3a- f with thioglycollic acid in benzene in presence of anhydrous ZnCl2 furnished desired novel compounds 3- (1 – Benzyl - 1h - Benzo [D] Imidazol – 2 - L Amino) – 2 - (3 –...
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