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CYTOGENETIC STUDY OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH ACUTE LEUKEMIA
The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. Conventional karyotyping which shows the structural, numerical and compound aberrations have improved the genetic diagnosis of leukemia. The bone marrow samples from patients (2-60yrs) of 53 patients (32 male and 21 female) suffering from vari...
4199
1450
SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF HYDROPHILIC AND LIPOPHILIC DRUGS
Improvement in the bioavailability of poorly soluble drugs is one of the challenges faced in the formulation development of the drugs. One of the most admirable and viable formulation approaches for this is self micro emulsifying drug delivery system (SMEDDS). A combination of clarithromycin and amoxicillin has been proved effective for treatment of H. pylori which are available only in tablet dos...
4199
1854
DEVELOPMENT AND CHARACTERIZATION OF BILAYERD TRANSDERMAL FILM OF DICLOFENAC DIETHYLAMINE
The aim of this research work was to develop and characterise bilayer film and to investigate its potential as slow-release wound healing vehicle. The bilayer is composed of an upper layer impregnated with Diclofenac diethyl amine and a drug-free lower layer, which acted as a rate-controlling membrane. Solvent casting technique was employed to prepare transdermal films. Pre formulation studies are...
4198
1896
CAFFEINE AND P-ANISALDEHYDE FROM THE FRUITS OF ENTEROLOBIUM SAMAN PRAIN
Fruits of the plant were air dried for several days and cut into small pieces, which were subjected to oven dried for 24 hours at 45-50°C to effect further chopping. Cold methanol extract of fruits were subjected to acid-base treatment to separate the alkaloids. The treated extract was subjected to column chromatography to isolate the pure compound. The xanthine alkaloid, 1, 3, 7-trimethyl-1H-pur...
4197
1698
STUDIES OF DRUG-POLYMER INTERACTIONS OF SIMVASTATIN WITH VARIOUS POLYMERS
The purpose of the present study is to prepare different combinations of drug Simvastatin (SV) with different polymers like Sodium alginate (SA), Hydroxypropylmethylcellulose (HPMC), Pectin (P), Dillenia (D) and Hydroxy propyl β- cyclodextrin. (HPC), thereby determine and report any possible interactions between the drug Simvastatin (SV) and various polymers both from natural and synthetic source...
4197
1731
VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1
Saponin derivatives from Vietnamese ginseng are proven for their efficacies in modulating oxidative stress, but there had been no reports about the interaction between them and two enzymes, endothelial nitric oxide synthase (eNOS) and cytochrome P450 2E1 (CYP2E1). eNOS and CYP2E1 are proposed to be attractive targets for the development of inhibitors against oxidative stress, a contributing factor...
4197
2217
CLINICAL EVALUATION OF T-AYU-HMTM IN THE MANAGEMENT OF SICKLE CELL ANEMIA
Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder...
4196
1480
METALLURGICAL AND SOLUBILITY STUDY OF ASHODHIT AND SHODHIT SROTONJANA
The mineral Srotonjana (antimony sulfide) is being used by Indians since ancient times. In Ayurvedic texts, it has been directed that Srotonjana should be used only after shodhana. Shodhana is a process to remove the unwanted physical, chemical impurities and toxic material and makes it suitable for medicinal use. Metallography is an advanced scientific study which is used in the study of the micr...
4196
2274
ANTIMICROBIAL ACTIVITY OF UNCOMBINED AND COMBINED EXTRACTS OF DOLIOCARPUS DENTATUS AND MONTRICARDIA ARBORESCENS
The antimicrobial activity of the individual extracts of Doliocarpus dentatus and Montricardia arborescens and combined extracts of both plants were investigated against bacterial strains E. coli, S. aureus and K. pneumoniae using the Disc/ Agar Diffusion method under asceptic conditions. The magnitude of the diameter of the zone of inhibition was used as an indication for antimicrobial susceptibi...
4195
1827
EVALUATION OF THE POSSIBLE ANTIOXIDANT EFFECTS OF PEGANUM HARMALA AND GINKGO BILOBA IN AMELIORATING ALZHEIMER’S DISEASE IN RAT MODEL
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder leading to dementia in the elderly inhabitants. Increasing evidence advises that oxidative stress that is normally associated with aging is an obvious and early feature of AD and plays a role in its pathogenesis. The present study was designed to evaluate the possible neuroprotective activity of Ginkgo biloba (Gb...
4195
1925