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ANTIBACTERIAL POTENTIAL, PHYTOCHEMICAL INVESTIGATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEIN OF DIFFERENT FRACTIONS OF ACALYPHA INDICA
Medicinal plants are extensively used to cure various infectious diseases in human. Our present study was undertaken to investigate antibacterial activity in leaf, stem and root extracts of Acalypha indica against the human pathogens such as Staphylococcus sp, E. coli, Salmonella sp, Klebsiella pneumonia and Pseudomonas. The shade dried leaves, stem and root powder was used to prepare extracts by ...
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ANTI TUBERULAR AND ANTHELMINTHIC ACTIVITIES OF AQUEOUS METHANOLIC EXTRACT OF CARALLUAMA ATTENUATA
Caralluma attenuata is a perennial small, leafless succulent plant which grows in tropical and subtropical areas. It belongs to the family Apocyanaceae. The folkal information reveals that the tribes generally chew the whole plant to treat peptic ulcer, diabetes, in weight reduction to suppress hunger and also to produce endurance. It has been reported for the presence of steroids, flavanoids, s...
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A STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS DETERMINATION OF TENELIGLIPTIN HYDROBROMIDE HYDRATE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM
A stability indicating UPLC method was developed and validated for the determination of Teneligliptin hydrobromide and Metformin hydrochloride in bulk and tablet dosage form. The method was carried out using Endoversil column (2.1 × 50 mm, 1.8 mm) with mobile phase consisting of 0.1% v/v ortho-phosphoric acid: acetonitrile (80: 20) under isocratic mode with an injection volume 1 µl and at flow r...
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NANOSTRUCTURED LIPID CARRIERS: THE ADVANCED LIPID CARRIERS AND THEIR APPLICATIONS
Nanostructured Lipid Carriers (NLCs) is a novel type of drug-delivery system. They are binary system which is stable in a different environment. Nanostructured Lipid Carrier (NLC) comprises a blend of solid and liquid lipids as a core matrix. NLCs have aggravated the incessant impulsion for developing safe and valuable drug delivery systems due to their exceptional physicochemical and biocompatibl...
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METALLURGICAL AND SOLUBILITY STUDY OF ASHODHIT AND SHODHIT SROTONJANA
The mineral Srotonjana (antimony sulfide) is being used by Indians since ancient times. In Ayurvedic texts, it has been directed that Srotonjana should be used only after shodhana. Shodhana is a process to remove the unwanted physical, chemical impurities and toxic material and makes it suitable for medicinal use. Metallography is an advanced scientific study which is used in the study of the micr...
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SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SEVERAL NEW N-SUBSTITUTED PHTHALIMIDE ANALOGUES
The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2–7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the ph...
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SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME TRANSITION METAL COMPLEXES WITH SUBSTITUTED ACETOPHENONE THIOSEMICARBAZONE
Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies. . Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted ace...
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ANTIOXIDANT ACTIVITY OF PLANTS AT CHINNATIRUPATHI, SALEM, TAMIL NADU, INDIA
This study was carried out during March - April 2013. The fresh leaves collected were extracted with water and used for antioxidant assay. Nitric oxide scavenging activity, Reducing power assay, Metal chelating activity, Phosphomolybdenum activity was assayed and also secondary metabolites such as phenol, flavonoid was estimated. These metabolites play a major role in antioxidant activity. Here,...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MORPHOLINE MANNICH BASE DERIVATIVES
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gra...
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STANDARDIZATION, FORMULATION & ANTIMICROBIAL ACTIVITY OF CASSIA TORA
Incidence of fungal infections is increasing at an alarming rate, presenting an enormous challenge to healthcare professionals. Despite advances in preventive, diagnostic, and therapeutic interventions, the invasive fungal infection causes significant morbidity and mortality in immunocompromised patients. An effective alternative to conventional synthetic antifungal agents can be the use of medici...
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