Most Popular
PLACKETT-BURMAN SCREENING OF OLMESARTAN MEDOXOMIL LIQUISOLID TABLETS: QUALITY BY DESIGN APPROACH
Solubility is considered as the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. Olmesartan medoxomil (OLM) is poorly soluble belongs to BCS class II. The drug is rapidly absorbed following oral administration, with a bioavailability approximately 26%. Liquisolid technique was used to enhance the aqueous...
2966
1959
STATUS OF DIABETIC HYPERTENSION IN KANPUR CITY AND ROLE OF PHARMACIST AS A HEALTHCARE PROFESSIONAL IN TREATMENT AND CONTROL OF DIABETIC HYPERTENSION
Pharmacists in all practice settings are in a key position to start providing care to people, who have diabetes or are at risk of developing it, or to expand and improve their care. Pharmacy programs for patients with diabetes involve activities ranging from identifying and referring at-risk patients, to supporting American Diabetes Association recognized multi-disciplinary diabetes care programs....
2966
1004
PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF VERAPAMIL
Mucoadhesive microcapsules of verapamil, a peripheral vasodilator, used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, have been prepared from sodium alginate, hydroxypropylmethyl cellulose- K4M & E5LV, Carbopol 934P using 10% w/v calcium chloride solution by ionic gelation method. Drug : polymer ratio was 1:1 in all formulations and polymer mixtures employed were 1:1, ...
2965
1092
MICROBIAL CONCRETE: THE PIONEERING WORK ON REPAIRING CONCRETE
The global demand of concrete is increasing every year and generally is considered as most consumed material on earth. But concrete is vulnerable to deterioration, corrosion, and cracks, and the consequent damage and loss of strength requires immensely expensive remediation and repair. One such mechanism that receives increasing attention in recent years is the ability for self-repair. So a nove...
2965
1105
RP-UPLC METHOD FOR COMBINATIONAL ASSAY OF LORNOXICAM AND PARACETAMOL IN COMBINED TABLET DOSAGE FORM
A simple, precise and stability-indicating ultra-performance liquid chromatography (UPLC) method for simultaneous determination of Paracetamol (PCM) and Lornoxicam (LOR) in tablet formulations has been developed and validated. The UPLC separation was achieved on a Waters Acquity UPLC BEH shield RPC18 (2.1x50mm, 1.7µm) column using acetonitrile:30mM Ammonium acetate (40:50, v/v) as mobile phase at...
2965
1350
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING ANALYSIS OF CHOLESTEROL INHIBITORS AGAINST NIEMANN-PICK C2 TARGET GENE (NPC2)
In an effort to develop new targets with enhanced antihyperlipidemic activity, seven new inhibitors such as beta-sitosterol, cholesterol, cholesterol sulfate, desmosterol, lathosterol, stigmasterol and cholesterol acetate was targeted using in silico docking experiments with the modeled structure of the Niemann-Pick C2 target gene (NPC2). Quantitative structure–activity relationship models (QSAR...
2965
1109
COMPUTING SANSKRUTI INDEX OF TURC4C8(S) NANOTUBE
Among topological descriptors connectivity indices are very important and they have a prominent role in chemistry. One of them is Sanskruti index defined as , where Su is the summation of degrees of all neighbours of vertex u in G. In this chapter we compute this new topological index for TURC4C8(S) nanotube....
2965
831
SYNTHESIS OF SOME 2, 3-DIARYL-6-ISOXAZYL-QUINOLINE-4-CARBOXYLIC ACID DERIVETIVES
A series of some new substituted quinolines were synthesized by Doebner reaction, a three component coupling of various aromatic amines with two aldehydes and phenyl pyruvic acid, the intermediate 2, 3-diary-6-acetyl-quinoline-4-carboxylic acids were reacted with various aromatic aldehydes in the presence of basic medium using Claisen-Schmidt condensation in order to afford the corresponding chalc...
2964
1228
EVALUATION OF EFFECTS OF PARTHENIUM HYSTEROPHORUS L., LEAVES EXTRACTS AGAINST MILK-INDUCED EOSINOPHILIA IN MICE
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950's and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and...
2964
1153
SMARTPHONE IS IT “BEHAVIOUR ADDICTION OR SUBSTANCE ABUSE DISORDER”: A REVIEW TO FIND CHEMISTRY BEHIND
Several behavioral addictions have been hypothesized as having similarities to substance abuse addictions. The DSM-4-TR has designated formal diagnostic criteria for several addictive disorders classifying them as impulse control disorders, a separate category from substance use disorder. There have been a lot of behavioral addiction studies like tanning, cosmetic surgery, sexual addiction, etc....
2964
1477