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Cu (II) METAL COMPLEXES OF SCHIFF BASES, PREPARATION, CHARACTERISATION AND BIOLOGICAL ACTIVITY
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance d...
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1893
STUDY OF STORAGE PERIODS OF CULTURE SUSPENSION OF STAPHYLOCOCCUS AUREUS
Staphylococcus aureus ATCC 6538 is an important strain of pharmaceutical and biotechnological industries. We studied the viability of culture suspension of Staphylococcus aureus strain ATCC 6538 at 2 to 8°C up to 360 days in 0.9% w/v NaCl. The culture suspension containing 10000 cfu/ml used in the study was stored at 2 to 8°C for 360 days in 0.9% w/v NaCl. Using 10 µl of above culture suspensio...
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NEUROPROTECTIVE ROLE OF HERB ECLIPTA ALBA LINN. ON ACUTE AND CHRONIC UNPREDICTABLE STRESS INDUCED BEHAVIORAL, BIOCHEMICAL AND NEURO-TRANSMITTER ALTERATION IN WISTAR MALE ALBINO RAT BRAIN
Chronic stress is a risk factor for the development of many psychopathological conditions in humans, including major depression and anxiety disorders and cognitive dysfunction. It is therefore important to focus on identifying possible mechanism to prevent these stress-induced disorders. Therefore, current study was designed to investigate the effect of Eclipta alba on chronic unpredicted stress (...
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1837
EUPHORBIA HIRTA LINN. – AN INVASIVE PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal us...
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MICRODOSING: A NEW STRATEGY FOR DRUG DEVELOPMENT PROCESS
New drugs are a great need for clinical conditions but unfortunately development costs are rising and number of drugs receiving marketing approval has fallen. Microdosing is a new experimental approach that offers a faster and potentially less expensive approach for obtaining human in vivo pharmacokinetic (PK) data in early stages of drug development. The concept of microdosing involves the use of...
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1989
PHYTOCHEMICAL STUDIES OF TWO SELECTED UNANI MEDICINAL PLANTS OF KALABURAGI REGION, KARNATAKA, INDIA
The present work was designed to perform the comparative study between the seeds of two selected plants i.e., Butea monosperma & Nigella sativa. The study includes phytochemical screening of primary and secondary metabolites, physico-chemical analysis, pharmacological studies, elemental analysis, and flouroscent studies. The comparative priliminary studies of Butea monosperma and Nigella sativ...
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1951
BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLE FROM COCCINIA GRANDIS AND ITS CATALYTIC ACTIVITY
The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray pow...
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3D QSAR AND MOLECULAR DOCKING STUDIES OF FLAVONOIDS AS SPLEEN TYROSINE KINASE INHIBITORS
Spleen tyrosine kinase (Syk) is a member of tyrosine kinase family protein. Syk protein plays a vital role during intracellular signal transduction from high affinity IgE receptor (FcεRI) in allergic reaction. Flavonoids are well known compounds for their anti-allergic properties. In this present work, thirty-four structurally similar flavonoids are investigated as Syk inhibitors by using 3-dimen...
4192
2017
SESAME OIL INCORPORATED MEDIUM FOR ISOLATION AND ENUMERATION OF LIPOPHILIC YEASTS
This communication reports on an easy and cost effective mycological medium, developed for primary isolation and culture of lipophilic yeasts. The medium has been modified and adjusted specifically to promote the growth of lipophilic yeasts and simultaneously suppress the growth of other fungi and bacteria. The traditional medium of Sabouraud’s dextrose agar (SDA) with olive oil overlay was modi...
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SPECTROPHOTOMETRIC ESTIMATION OF MONTELUKAST FROM BULK DRUG AND TABLET DOSAGE FORM
Two Simple, accurate, precise and sensitive spectrophotometric methods for estimation of Montelukast sodium (MON) have been developed and validated. The zero order spectroscopic method (Method I) and area under curve method (Method II) have developed. The proposed methods are validated according to ICH Q2B guidelines. The Montelukast sodium gives maximum absorbance at 241nm in chloroform and obser...
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