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SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SEVERAL NEW N-SUBSTITUTED PHTHALIMIDE ANALOGUES
The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2–7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the ph...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MORPHOLINE MANNICH BASE DERIVATIVES
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gra...
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2169
STANDARDIZATION, FORMULATION & ANTIMICROBIAL ACTIVITY OF CASSIA TORA
Incidence of fungal infections is increasing at an alarming rate, presenting an enormous challenge to healthcare professionals. Despite advances in preventive, diagnostic, and therapeutic interventions, the invasive fungal infection causes significant morbidity and mortality in immunocompromised patients. An effective alternative to conventional synthetic antifungal agents can be the use of medici...
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1839
SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME TRANSITION METAL COMPLEXES WITH SUBSTITUTED ACETOPHENONE THIOSEMICARBAZONE
Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies. . Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted ace...
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TRADITIONAL, PHYTOCHEMICAL AND BIOLOGICAL ACTIVITIES OF ELETTARIA CARDAMOMUM (L.) MATON – A REVIEW
The Elettaria Maton genera belonging to the Zingiberaceae family is native to South India to West Malesia. From ancient times this genus has been largely explored for its biological properties. Various pharmacological properties such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects have been related to this genus. E. cardamomum also acts as an Ayurvedic aphrodisiac and remed...
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SESAME OIL INCORPORATED MEDIUM FOR ISOLATION AND ENUMERATION OF LIPOPHILIC YEASTS
This communication reports on an easy and cost effective mycological medium, developed for primary isolation and culture of lipophilic yeasts. The medium has been modified and adjusted specifically to promote the growth of lipophilic yeasts and simultaneously suppress the growth of other fungi and bacteria. The traditional medium of Sabouraud’s dextrose agar (SDA) with olive oil overlay was modi...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LEAVES OF ECLIPTA PROSTRATA LINN. (ASTERACEAE)
Eclipta prostrata Linn. (Asteraceae) popularly known as "Bhringaraj" is a very useful medicinal plant in India. The aim of the present study is to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Eclipta prostrata. The anti-inflammatory effects were investigated by employing acute inflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin ...
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1785
FIRST DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN TABLETS
Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods...
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EFFECT OF ETHANOL EXTRACT OF TERMINALIA CHEBULA ON THE MOTILITY AND ACETYLCHOLINESTERASE OF COTYLOPHORON COTYLOPHORUM
Cotylophoron cotylophorum, the parasite of ruminants cause a disease called paramphistomosis. Paramphistomosis in domesticated ruminants cause considerable economic loss to the livestock industry in India. In the present study, the anthelmintic activity of Terminalia chebula was assessed based on its effects on the motility and acetylcholinesterase (AChE) of the digenetic trematode C. cotylophorum...
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1715
FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM COMPRESSION COATED TABLETS BY OKRA GUM AS A BINDER
The purpose of the present study was to formulate Losartan potassium compression-coated tablets using okra gum as a binder along with synthetic hydrophilic polymers like various grades of Hydroxypropyl methylcellulose (HPMC) and compare the different parameters. The effect of different concentration of okra is to be used in the formulations with varying concentration of the polymers, elucidating t...
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