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SPECTROPHOTOMETRIC ESTIMATION OF MONTELUKAST FROM BULK DRUG AND TABLET DOSAGE FORM
Two Simple, accurate, precise and sensitive spectrophotometric methods for estimation of Montelukast sodium (MON) have been developed and validated. The zero order spectroscopic method (Method I) and area under curve method (Method II) have developed. The proposed methods are validated according to ICH Q2B guidelines. The Montelukast sodium gives maximum absorbance at 241nm in chloroform and obser...
4147
1712
3D QSAR AND MOLECULAR DOCKING STUDIES OF FLAVONOIDS AS SPLEEN TYROSINE KINASE INHIBITORS
Spleen tyrosine kinase (Syk) is a member of tyrosine kinase family protein. Syk protein plays a vital role during intracellular signal transduction from high affinity IgE receptor (FcεRI) in allergic reaction. Flavonoids are well known compounds for their anti-allergic properties. In this present work, thirty-four structurally similar flavonoids are investigated as Syk inhibitors by using 3-dimen...
4147
1984
RESEALED ERYTHROCYTES AS A POTENTIAL DRUG CARRIER SYSTEM
Novel drug delivery system has been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms. Out of various cellular carrier systems, erythrocytes (red blood cells, RBC) have been the most widely investigated and found to possess great potential for the delivery of drugs and drug-loaded microspheres. These cellular carriers, having remarkable bioco...
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1626
TRADITIONAL, PHYTOCHEMICAL AND BIOLOGICAL ACTIVITIES OF ELETTARIA CARDAMOMUM (L.) MATON – A REVIEW
The Elettaria Maton genera belonging to the Zingiberaceae family is native to South India to West Malesia. From ancient times this genus has been largely explored for its biological properties. Various pharmacological properties such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects have been related to this genus. E. cardamomum also acts as an Ayurvedic aphrodisiac and remed...
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2898
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM, LEVOCETIRIZINE DIHYDROCHLORIDE AND ACEBROPHYLLINE IN FIXED-DOSE COMBINATION TABLETS
A fixed-dose combination of montelukast sodium, levocetirizine dihydrochloride, and acebrophyl line is used in the treatment of asthma, COPD, allergic rhinitis and other conditions where patients feel difficulty in breathing. The present study was designed to develop and validate a simple, sensitive, precise and accurate isocratic reverse-phase high-performance liquid chromatography (HPLC) method ...
4146
1768
SESAME OIL INCORPORATED MEDIUM FOR ISOLATION AND ENUMERATION OF LIPOPHILIC YEASTS
This communication reports on an easy and cost effective mycological medium, developed for primary isolation and culture of lipophilic yeasts. The medium has been modified and adjusted specifically to promote the growth of lipophilic yeasts and simultaneously suppress the growth of other fungi and bacteria. The traditional medium of Sabouraud’s dextrose agar (SDA) with olive oil overlay was modi...
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6429
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LEAVES OF ECLIPTA PROSTRATA LINN. (ASTERACEAE)
Eclipta prostrata Linn. (Asteraceae) popularly known as "Bhringaraj" is a very useful medicinal plant in India. The aim of the present study is to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Eclipta prostrata. The anti-inflammatory effects were investigated by employing acute inflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin ...
4145
1795
COMPARATIVE ANTI-ANXIETY POTENTIAL OF DIFFERENT PARTS OF VITEX NEGUNDO LINN.
Vitex negundo, commonly called Nirgundi, is one of the widely investigated medicinal plants of India. The present study were planned to compare different parts, i.e. leaves, stems and roots of V. negundo for antianxiety activity using elevated plus maze model. Petroleum ether (60 - 80 °C), chloroform, ethanol and aqueous extracts of these parts were prepared and evaluated for anti-anxiety activit...
4145
1783
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 1, 6- DIPHENYL-10, 10a-DIHYDROPYRIDO[2, 3-d]-1, 2, 4-TRIAZOLO [4, 3-a]PYRIMIDIN-5(1H)-ONE DERIVATIVES
In this research, a new series of total twenty derivatives (39-58) of titled compound were synthesized with the help of substituted acetophenone which undergoes Aldol condensation reaction with dimethyformamidedimethylacetal (DMFDMA) to form corresponding unsaturated carbonyl compounds such as enaminones. The compound 2-thioxo-1,3-dihydropyridino[2,3-d] pyrimidin-4(1H)-one were obtained by reactin...
4143
2639
FIRST DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN TABLETS
Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods...
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1567