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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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7.

VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1

Saponin derivatives from Vietnamese ginseng are proven for their efficacies in modulating oxidative stress, but there had been no reports about the interaction between them and two enzymes, endothelial nitric oxide synthase (eNOS) and cytochrome P450 2E1 (CYP2E1). eNOS and CYP2E1 are proposed to be attractive targets for the development of inhibitors against oxidative stress, a contributing factor...

T. T. T. Do, H. T. T. Nguyen, Q. H. T. Duong, S. H. Le and P. T. V. Nguyen *

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Đinh Tien Hoang Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.

DOI: 10.13040/IJPSR.0975-8232.10(1).70-82

70-82

4136

2188

35.

A COMPERATIVE STUDY OF VANADIUM PENTOXIDE AND CHROMIUM OXIDE IN STREPTOZOTOCIN INDUCED DIABETES IN ALBINO RATS

Objectives: The present study was conducted to evaluate and compare the effect of vanadium pentoxide and chromium oxide in normal and streptozotocin induced diabetic albino rats. Methods: Diabetes was experimentally induced by injecting intraperitoneally with a single dose of 60mg/kg.  The animals were considered as diabetic, if their blood glucose values were above 300 mg/dl on the 10th day afte...

Pradumna Pathak* and Mangala Lahkar

Department of Pharmacology, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, India

DOI: 10.13040/IJPSR.0975-8232.6(11).4843-46

4843-46

4135

1371

26.

EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL

Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare eff...

Mehwish Majeed * and Yogita S Karandikar

Department of Pharmacology, Government Medical College, Srinagar, Kashmir, India

DOI: 10.13040/IJPSR.0975-8232.7(6).2492-98

2492-98

4135

1929

10.

ONCE DAILY GASTRO RETENTIVE MUCOADHESIVE CEPHALEXIN MONOHYDRATE TABLET: FORMULATION AND IN-VITRO EVALUATION

Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polymer ...

K. G. Parthiban*, B. Senthil Kumar, R. Manivannan and D. Sanjeevi kumar

Department of Pharmaceutics, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam, Namakkal (DT), Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(5).89-98

89-98

4134

1661

50.

IMPACT OF CLINICAL PHARMACIST IN THE MONITORING OF DRUG – RELATED PROBLEMS IN PSYCHIATRY PATIENTS AT TERTIARY CARE TEACHING HOSPITAL

Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortalit...

S. C. Wali, M. S. Ganachari, A. S. Parihar * and S. B. Sonawale

Department of Pharmacy Practice, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(2).819-23

819-823

4134

1404

45.

BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLE FROM COCCINIA GRANDIS AND ITS CATALYTIC ACTIVITY

The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray pow...

N. C. S. Reddy, M. Nageshwar and G. B. Reddy *

Department of Chemistry, PG Centre Wanaparthy, Palamuru University, Mahbubnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(9).4391-95

4391-4395

4134

1465

11.

DEVELOPMENT AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF SALBUTAMOL SULPHATE USING METHOCEL K100M CR POLYMER

In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Salbutamol sulphate, an anti-asthmatic agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of salbutamol sulphate were prepared by direct compression process using methocel K100M CR polymer. Rele...

Md. Qamrul Ahsan , Md. Mofizur Rahman, Mithilesh Kumar Jha , Ishtiaq Ahmed, Md. Mizanur Rahman Moghal and Md. Habibur Rahman

Department of Pharmacy, Bangladesh University, Mohammadpur, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(3).567-76

567-576

4133

1725

37.

DNA BINDING AND NUCLEASE ACTIVITY OF STRUCTURALLY CHARACTERIZED COPPER(II) COMPLEX

A mononuclear copper(II) complex [Cu(bpy)2(NO3)] NO3 H2O (bpy = 2,2’-bipyridine) has been synthesized and characterized based on physico-chemical spectral data. The complex is characterized based on electronic, IR and ESR spectroscopies.  The structure of the complex is determined by single crystal X-Ray crystallography. The complex crystallizes in monoclinic space group P-1.  Structural analy...

S. Chandrasekhar and K. Hussain Reddy*

Department of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.7(10).4204-13

4204-13

4133

1690

50.

NUTRACEUTICALS: A SLOW TRANSITION FROM PREVENTIVE TO CURATIVE HEALTHCARE AND THE PERCEPTIONS AMONG PHYSICIANS AND PATIENTS – A STUDY OF SOUTH DELHI IN INDIA

Introduction: The health and wellness sector is bracing for a radical change with Information and Communication Technology taking the leading role in research and development, diagnostics, and monitoring. The consumer’s focus is shifting from treatment-based remedies to preventive remedies gradually. Aim: To explore the slow transition from curative to preventive healthcare in the prescribing be...

T. U. Zaman *, H. A. Adetunji and E. F. M. Salih

Department of Health Information Management and Technology, Faculty of Public Health and Health Informatics, Umm Al Qura University, Aziziyah, Makkah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(7).3113-17

3113-3117

4133

1465

30.

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET

The objective of the study is to design gastro retentive drug delivery systems for Amoxycillin trihydrate. It was prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. The preparation was carried out by using guar gum as a carrier in the form ...

Garima Gupta* and Amit Singh

Department of Pharmaceutics, R.V. Northland Institute, Dadri, Gautam Buddha Nagar, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.4(7).2683-90

2683-2690

4132

1692