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DNA BINDING AND NUCLEASE ACTIVITY OF STRUCTURALLY CHARACTERIZED COPPER(II) COMPLEX
A mononuclear copper(II) complex [Cu(bpy)2(NO3)] NO3 H2O (bpy = 2,2’-bipyridine) has been synthesized and characterized based on physico-chemical spectral data. The complex is characterized based on electronic, IR and ESR spectroscopies. The structure of the complex is determined by single crystal X-Ray crystallography. The complex crystallizes in monoclinic space group P-1. Structural analy...
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PREVALENCE AND CORRELATION OF VIRAL INFECTION (HEPATITIS B OR/AND HEPATITIS C) AMONG HYPERTENSIVE AND DIABETIC PATIENTS IN MALAYSIA AND INDONESIA WHO UNDERWENT HEMODIALYSIS
Background: Increase prevalence of viral infection such as hepatitis B or/and hepatitis C are followed by high incidence of mortality among hemodialysis patients. Objective: To determine prevalence and correlation of viral infection (Hepatitis B or/and Hepatitis C) among Hemodialysis Patients that died for the last five years in Indonesia and Malaysia in relation to gender, age, causes, and countr...
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VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1
Saponin derivatives from Vietnamese ginseng are proven for their efficacies in modulating oxidative stress, but there had been no reports about the interaction between them and two enzymes, endothelial nitric oxide synthase (eNOS) and cytochrome P450 2E1 (CYP2E1). eNOS and CYP2E1 are proposed to be attractive targets for the development of inhibitors against oxidative stress, a contributing factor...
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DEVELOPMENT AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF SALBUTAMOL SULPHATE USING METHOCEL K100M CR POLYMER
In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Salbutamol sulphate, an anti-asthmatic agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of salbutamol sulphate were prepared by direct compression process using methocel K100M CR polymer. Rele...
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A COMPERATIVE STUDY OF VANADIUM PENTOXIDE AND CHROMIUM OXIDE IN STREPTOZOTOCIN INDUCED DIABETES IN ALBINO RATS
Objectives: The present study was conducted to evaluate and compare the effect of vanadium pentoxide and chromium oxide in normal and streptozotocin induced diabetic albino rats. Methods: Diabetes was experimentally induced by injecting intraperitoneally with a single dose of 60mg/kg. The animals were considered as diabetic, if their blood glucose values were above 300 mg/dl on the 10th day afte...
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EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare eff...
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ONCE DAILY GASTRO RETENTIVE MUCOADHESIVE CEPHALEXIN MONOHYDRATE TABLET: FORMULATION AND IN-VITRO EVALUATION
Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polymer ...
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NUTRACEUTICALS: A SLOW TRANSITION FROM PREVENTIVE TO CURATIVE HEALTHCARE AND THE PERCEPTIONS AMONG PHYSICIANS AND PATIENTS – A STUDY OF SOUTH DELHI IN INDIA
Introduction: The health and wellness sector is bracing for a radical change with Information and Communication Technology taking the leading role in research and development, diagnostics, and monitoring. The consumer’s focus is shifting from treatment-based remedies to preventive remedies gradually. Aim: To explore the slow transition from curative to preventive healthcare in the prescribing be...
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IDENTIFICATION AND HPLC QUANTIFICATION OF AFLATOXINS IN GROUNDNUT (ARACHIS HYPOGAEA L.) SAMPLES COLLECTED IN RAYALASEEMA AREA, ANDHRA PRADESH
The present investigation reports the fungal Aflatoxins contamination in groundnut samples collected in different locations in the Rayalaseema area, Andhra Pradesh, India. Aflatoxins were extracted by liquid-liquid extraction method using chloroform solvent. The qualitative and quantitative analysis of aflatoxins present in the samples was done using TLC and HPLC techniques. Among the eight sample...
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BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLE FROM COCCINIA GRANDIS AND ITS CATALYTIC ACTIVITY
The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray pow...
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