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ONCE DAILY GASTRO RETENTIVE MUCOADHESIVE CEPHALEXIN MONOHYDRATE TABLET: FORMULATION AND IN-VITRO EVALUATION
Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polymer ...
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EFFECT OF FICUS HISPIDA IN INFLAMMATORY BOWEL DISEASE IN EXPERIMENTAL ANIMALS
Background: Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal condition. Conventional treatment regimens utilizing corticosteroids, anti-inflammatory and other immunosuppressive therapies have major limitations owing to their associated side effects and compliance issues. Objectives: To evaluate the effect of ethanolic extract of Ficus hispida Linn. in inflammatory bowe...
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1872
COMPARATIVE ANTI-ANXIETY POTENTIAL OF DIFFERENT PARTS OF VITEX NEGUNDO LINN.
Vitex negundo, commonly called Nirgundi, is one of the widely investigated medicinal plants of India. The present study were planned to compare different parts, i.e. leaves, stems and roots of V. negundo for antianxiety activity using elevated plus maze model. Petroleum ether (60 - 80 °C), chloroform, ethanol and aqueous extracts of these parts were prepared and evaluated for anti-anxiety activit...
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1779
DEVELOPMENT AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF SALBUTAMOL SULPHATE USING METHOCEL K100M CR POLYMER
In the present study, an attempt has been made to evaluate the effect of hydrophilic polymers on the release profile of drug from matrix system. Salbutamol sulphate, an anti-asthmatic agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of salbutamol sulphate were prepared by direct compression process using methocel K100M CR polymer. Rele...
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1721
FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET
The objective of the study is to design gastro retentive drug delivery systems for Amoxycillin trihydrate. It was prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. The preparation was carried out by using guar gum as a carrier in the form ...
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1690
BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLE FROM COCCINIA GRANDIS AND ITS CATALYTIC ACTIVITY
The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray pow...
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1460
ANTIOXIDANT, ANALGESIC AND CYTOTOXIC ACTIVITIES OF MIMUSOPS ELENGI LINN. LEAVES
Mimusops elengi Linn. (Family: Sapotaceae) is a tree which is traditionally used against a number of diseases including ulcers, headache, dental diseases, wound and fever. In the present study crude methanolic extract of Mimusops elengi Linn. leaf was investigated for possible antioxidant, analgesic and cytotoxic activity. The extract exhibited statistically significant antioxidant activity in DPP...
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1512
PREVALENCE AND CORRELATION OF VIRAL INFECTION (HEPATITIS B OR/AND HEPATITIS C) AMONG HYPERTENSIVE AND DIABETIC PATIENTS IN MALAYSIA AND INDONESIA WHO UNDERWENT HEMODIALYSIS
Background: Increase prevalence of viral infection such as hepatitis B or/and hepatitis C are followed by high incidence of mortality among hemodialysis patients. Objective: To determine prevalence and correlation of viral infection (Hepatitis B or/and Hepatitis C) among Hemodialysis Patients that died for the last five years in Indonesia and Malaysia in relation to gender, age, causes, and countr...
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NUTRACEUTICALS: A SLOW TRANSITION FROM PREVENTIVE TO CURATIVE HEALTHCARE AND THE PERCEPTIONS AMONG PHYSICIANS AND PATIENTS – A STUDY OF SOUTH DELHI IN INDIA
Introduction: The health and wellness sector is bracing for a radical change with Information and Communication Technology taking the leading role in research and development, diagnostics, and monitoring. The consumer’s focus is shifting from treatment-based remedies to preventive remedies gradually. Aim: To explore the slow transition from curative to preventive healthcare in the prescribing be...
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1463
IMPACT OF CLINICAL PHARMACIST IN THE MONITORING OF DRUG – RELATED PROBLEMS IN PSYCHIATRY PATIENTS AT TERTIARY CARE TEACHING HOSPITAL
Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortalit...
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