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QUANTITATIVE ESTIMATION OF DRUGS AND PHARMACEUTICALS USING CHLORAMINE-T AND SAFRANIN-O DYE BY AN OXIDATIVE SPECTROPHOTOMETRIC METHOD
Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., Cetirizine hydrochloride, Duloxetine hydrochloride, Esmolol hydrochloride, Gemifloxacin, Moxifloxacin and Phenylephrine Hydrochloride based on their reactivity towards Chloramine-T (ChL-T). The method is based on the oxidation of drugs by ChL-T (Excess amount) in presence of acidic medium...
4131
1805
ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF METHANOLIC EXTRACT OF FILICIUM DECIPIENS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
This study evaluated methanolic extract of Filicium decipiens (MFD) on reducing hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. MFD was orally administered once a day after 3 days of streptozotocin -induction at 100,200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, Glucose – 6 – phosphotase , Fructose 1, 6 –phosphotase in hepatic ...
4130
1934
CYTOTOXIC ACTIVITY OF N-HEXANE, CHLOROFORM AND CARBON TETRACHLORIDE FRACTIONS OF THE ETHANOLIC EXTRACT OF LEAVES AND STEMS OF BACCAUREA RAMIFLORA (LOUR.).
The purpose of the study was to find out the cytotoxic activity of the n-hexane, chloroform and carbon tetrachloride fractions of the ethanolic extracts of the leaves and stems of Baccaurea ramiflora (Lour.). Ethanolic extracts of the leaves and stems of Baccaurea ramiflora were subjected to solvent-solvent partitioning using n-hexane, chloroform and carbon tetrachloride to obtain n-hexane leaves ...
4130
1804
DESIRE FOR FERTILITY AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS (PLWHA) IN SELECTED ANTIRETROVIRAL THERAPY (ART) CLINICS OF HORRO GUDURU WOLLEGA ZONE, NORTH WEST OROMIA, ETHIOPIA- A CROSS SECTIONAL STUDY
Background: Most recently fertility issues in HIV positive men and women are becoming increasingly important. Because of ART access and its good life effect, it is expected that the need and desire to get married, to have children and to have sexual partners for PLWHA would change with the regard to reproductive health. In Ethiopia HIV positive individuals may or may not have desire to have childr...
4130
1631
DEVELOPMENT AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLET OF OFLOXACIN
Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of ofloxacin with indion 204 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activat...
4130
1674
BIO EFFICACY OF MICHELIA CHAMPACA LINN ON MEMBRANE BOUND ENZYMES IN CCl4 INDUCED HEPATOTOXICITY IN RATS
The aim of the present study is to evaluate the protective effect of flower extract of Michelia champaca on membrane bound enzyme (serum ATPase) levels on male albino rats. The membrane bound enzymes (Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase) levels of methanolic flower extract of Michelia champaca at a dose of 300 mg/kg was evaluated during exposure to CCl4. There was a significant decrease i...
4130
1541
PROSPECTIVE STUDY ON ROLE OF CRP AS AN INFLAMMATORY MARKER IN TYPE-II DIABETES MELLITUS IN TERTIARY CARE HOSPITAL
Globally at present, there are an estimated 366 million people affected with diabetes mellitus. The Indian figure is around 61.3 million diabetics, which is projected to cross 100 million by the year 2030. Owing to rise of diabetes mellitus cases, the economic burden due to diabetes in India ranks the highest in the world. With the increasing prevalence of diabetes, it has resulted in an increase ...
4130
1609
ANTIPLASMODIAL ACTIVITY OF EXTRACTS OF KHAYA SENEGALENSIS (DERS.) A. JUS (MELIACEAE) AND MELIA AZEDARACH L., PLANTS OF SENEGALESE TRADITIONAL MEDICINE
Two medicinal plants (Khaya senegalensis and Melia azedarach), frequently used by a large part of the Senegalese population and in particular that of the natural region of Casamance in the traditional treatment of malaria, were selected to study phytochemistry and to compare the antimalarial activity of the different parts used (leaves, bark, and seeds). The extraction of these drugs was carried o...
4130
1595
NEEM LEAF EXTRACT PREVENTS METHOTREXATE INDUCED GENOTOXICITY IN THE SOMATIC CELLS OF DROSOPHILA MELANOGASTER”
Background &Objective: To explore possible protective effect of neem leaf extract against methotrexate induced genotoxicity in the somatic cells (wing primordial) of Drosophila melanogaster. Methods: In the first phase of the experiment, neem leaf extract (NLE) at two doses was tested in the somatic cells (wing primordia) of Drosophila melanogaster (3rd instar trans heterozygous larvae resu...
4129
1637
A VALIDATED HPLC METHOD FOR ESTIMATION OF LORN AND PCM IN THEIR COMBINED TABLET DOSAGE FORM
The present work describes a reverse phase high performance liquid chromatographic method without use of buffer in mobile phase for the simultaneous estimation of Lornoxicam and Paracetamol in combined tablet dosage form. Chromatography was performed on Chromasil C18 (250 × 4.6 mm i.d. and particle size 5 μm) column in isocratic mode with mobile phase containing acetonitrile: 0.2% triethylamine ...
4129
1497