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THROMBOLYTIC POTENTIAL OF PUNICA GRANATUM – A STUDY IN THE RAT MODEL
Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation...
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SCREENING OF ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF LAGERSTROEMIA SPECIOSA (LINN.) PERS. LEAVES
The present study was designed to investigate the hypolipidemic activity of the methanolic leaf extract of Lagerstroemia speciosa Linn. Plant extract was tested in fat diet induced hyperlipidemic rat models. Methanolic extracts of leaves of Lagerstroemia speciosa Linn. were administered in doses of 250mg/kg and 500mg/kg/day for one week. The obtained results reveal that methanolic leaf extract (LM...
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EVALUATION OF CNS DEPRESSANT AND ANALGESIC ACTIVITIES OF THE METHANOL EXTRACT OF PIPER LONGUM LINN. LEAVES
Present study reports CNS depressant and analgesic activities of methanol extract obtained from the leaves of Piper longum L (MEPL). CNS depressant activity was evaluated by using open field and hole cross tests at doses of 250 and 500 mg/kg body weight while peripheral analgesic activity was evaluated by using acetic acid induced writhing method and formalin test respectively in rat model at 100 ...
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CONTROLLED RELEASE OF AN ANTI- EMETIC AGENT FROM A POLYMERIC MATRIX: FORMULATION AND IN- VITRO STUDY
The objective of the present study was to develop once daily controlled-release matrix tablets of Domperidone Maleate, an anti- emetic agent. Several formulations containing an anti- emetic agent (domperidone maleate) and hydrophilic polymers (Hydroxypropyl methylcellulose, Carbopol and Polyethylene oxide) were prepared by wet granulation methods. The tablets were subjected to thickness, diameter,...
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THE SUCCESS OF DIFFERENT APPROACHES TO THE DEVELOPMENT TO ANTIPLATELET DRUGS
The aim of this research is to precisely discuss and appraise the success of different approaches to the development to antiplatelet drugs. Platelets play a main function in haemostasis and the development of arterial thrombosis that is the final event complicating cardiovascular diseases and peripheral vascular diseases, and antiplatelet drugs improve survival of patients with these diseases. Ant...
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EVALUATION OF ANTICONVULSANT ACTIVITY OF THE LEAVES ETHANOLIC AND AQUEOUS EXTRACTS OF NYCTANTHES ARBORTRISTIS LINN. AGAINST SEIZURES INDUCED BY PENTYLENETETRAZOLE AND ELECTROCONVULSIVE SHOCK IN MICE
Nyctanthes arbortristis Linn. (Oleaceae) which has been used as an antiepileptic remedy in tribal people of India (Orissa and Bihar) along with its use in Ayurveda, Sidha and Unani systems of medicine was evaluated for anticonvulsant activity against experimental seizures. The leaves ethanolic and aqueous extracts of N. arbortristis protected mice against tonic convulsions induced by maximal elect...
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ENHANCEMENT OF DISSOLUTION RATE AND FORMULATION DEVELOPMENT OF RITONAVIR TABLETS EMPLOYING STARCH PHOSPHATE- A NEW MODIFIED STARCH
The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...
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FORMULATION OF NICERDIPINE HYDROCHLORIDE INCLUSION COMPLEX FOR DISSOLUTION ENHANCEMENT
The purpose of this study was to improve the dissolution rate of poorly soluble Nicardipine hydrochloride with cyclodextrin complexation by using different techniques like physical mixing, solvent evaporation and kneading method. Nicardipine hydrochloride is a calcium channel blocker. It is belonging to BCS class - II having poor solubility and high permeability. It is used to treat Angina having ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF DOXAZOSIN MESYLATE
The objective of the present investigation was to develop a sustained release (SR) tablets of Doxazosin Mesylate by wet granulation technique using a combination of synthetic polymers (Eudragit RS-100 and Eudragit RL-100). Different batches of Doxazosin Mesylate sustained release tablets were prepared by using microcrystalline cellulose as diluents by wet granulation technique. The compatibility o...
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EXPRESSION OF CHICKEN ANEMIA VIRUS VP3 GENE IN HeLa CELLs
Chicken anemia virus (CAV) encodes the protein VP3 also named “apoptin” that specifically induces apoptosis in human tumor cells. In this study, the VP3 gene cloned in p VAX1 plasmid vector was transfected in HeLa cells. The expression of CAV VP3 gene was detected using immunoperoxidase test and indirect fluorescent antibody technique. High level of gene expression was observed in HeLa cell cu...
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