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A STUDY ON THE ROLE OF DIETARY AGENT MOMORDICA CHARANTIA L ON PROTEIN GLYCATION
Protein glycation is a spontaneous post translational modification of proteins by excess sugars causing formation of advanced glycation end products (AGEs) in diabetic individuals and responsible for diabetes complications. A wide variety of anti-glycating agents have been reported & recently there has been interest in natural products with anti-glycation properties. Momordica charantia L (M. ...
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SYNTHESIS AND SCREENING N-(2, 4′-DIOXO-1, 2-DIHYDRO-3’H-SPIRO [INDOLE-3, 2′-[1,3]THIAZOLIDIN]-3′-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY
A novel synthesis of N-(2, 4'-dioxo-1, 2-dihydro-3'H-spiro [indole-3, 2'-[1, 3] thiazolidin]-3'-yl)-2 -hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, 1H-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 µg/...
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COMPARISON OF DIFFERENT SUPERDISINTEGRANTS IN DESIGNING OF FAST DISSOLVING TABLETS OF METOPROLOL TARTRATE
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Th...
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VASORELAXATION EFFECT PROMOTED BY THE CALCIUM CHANNEL BLOCKER VERAPAMIL COORDINATED TO RUTHENIUM (II): CHEMICAL AND BIOLOGICAL PROPERTIES
This paper presents the synthesis and physical-chemical characterization of a new terpyridine (tpy) ruthenium complex coordinated to the L-type calcium blocker channels verapamil (vera) obtained from commercial pill. Elemental analysis (%C N H), infrared (IR) and ultraviolet-visible (UV-vis.) spectroscopy, mass spectrometry (MS), and 13CNMR (nuclear magnetic resonance), and HPLC (high performance ...
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SYNTHESIS AND TESTING OF METAL COMPLEXES OF QUINOXALINE BASED SCHIFF BASES FOR ANTIMICROBIAL AND ANTICANCER ACTIVITIES
The compound 3-chloro-2-hydrazine quinoxaline was condensed with 2-furaldehyde to derive a Schiff base 2-furaldehyde-2-(3-chloro-2-quinoxalinyl) hydrazone (FCCQH).The ligand and also its complexes with VO (IV), Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Zn (II), and Pd (II) have been synthesized and characterized by elemental analysis, magnetic studies, thermal analysis, infrared spectra, UV-v...
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EFFECT OF CURCUMIN SUPPLEMENTATION ON THE SUBMANDIBULAR SALIVARY GLANDS OF D-GALACTOSE INDUCED MALE MICE
Significant increase in the salivary gland lipid peroxidation, fluorescence product as well as accumulation of lipofuscin granules–age pigment was observed after injection of 5% D-galactose 0.5 ml daily for 30 days. Supplementations of turmeric extract (30mg/kg body weight) for 30 days during and after D-galactose treatment significantly reduced all the above parameters. Histochemical changes in...
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PRELIMINARY PHYTOCHEMICAL INVESTIGATION AND HPTLC FINGER PRINTING OF AN ANTIDIABETIC POLYHERBAL FORMULATION
The aim of the present work was to investigate the phytochemical components of an antidiabetic polyherbal formulation. The formulation was prepared using ingredients of Azadirachta indica A. Juss, Commiphora mukul, Curcuma longa L, Emblica officinalis Gaertn, Garcinia cambogia Gaertn, Gymnema sylvestre Retz, Momordica charantia L, Ocimum sanctum L and Trigonella foenum-graecum L. The formulation w...
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SYNTHESIS AND CHARACTERIZATION OF PVA BASED SERICIN FILM FOR ANTIBACTERIAL WOUND DRESSING
Sericin is a globular protein obtained from degumming of silk cocoon in the silk reeling process. The sericin film was synthesized for the application of antibacterial wound dressing, but it has a low physical property, hence the synthetic polymer was used in the synthesis of highly stable biocompatible film. The PVA based sericin film was prepared by solvent casting method by the addition of synt...
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SYNTHESIS OF 3- (1 – BENZYL – 1H – BENZO [D] IMIDAZOL – 2 – L AMINO) – 2 – (3 – ARYL – 1- PHENYL – 1H – PYRAZOL – 4 – YL) THIAZOLIDIN – 4- ONES AND THEIR ANTIMICROBIAL ACTIVITIES
Reaction of 1- (1- benzyl- 1H- benzo [d] imidazol- 2- yl) hydrazine (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff bases (3a-f). Further, cyclization of compounds 3a- f with thioglycollic acid in benzene in presence of anhydrous ZnCl2 furnished desired novel compounds 3- (1 – Benzyl - 1h - Benzo [D] Imidazol – 2 - L Amino) – 2 - (3 –...
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ANTIBACTERIAL ACTIVITIES OF OLD AND YOUNG LEAVES OF OLEA EUROPAEA (OLIVE TREE) OF ALJOUF REGION, SAUDI ARABIA
Antibacterial activities of different solvent extracts of young and old leaves has been evaluated against Pseudomonas aeureginosa (ATTCC10145) an opportunistic bacteria by Agar Well Diffusion Method. Extracts of olive leaves have been prepared by using standard extraction methods and DMS was used as vehicle for all the extracts. Amikacin was used as standard drug to which P. aeruginosa was found s...
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