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GC-MS STUDY OF IXORA PAVETTA VAHL.
Ixora pavetta Vahl. is a small tree, traditionally used for the treatment of diarrhoea, dysentery, urinary disorders, leucorrhoea, veneral diseases and sedative. The flowers of the plant were extracted with ethanol by cold percolation method. The presence of the compounds in the extract was analyzed by GC-MS technique. The parameters of mass spectral analysis viz. retention time and characteristic...
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SPECTRAL STUDIES OF NEW ORGANOMETALLIC SCHIFF BASE COMPLEXES AND THEIR ANTI-FUNGAL ACTIVITY
Synthesis of new organometallic Schiff bases complexes with general formula [ML)xH2O] [where M = Mn(II), Ni(II), Cu(II) Pd(II) and Pt(II), L=2,2'-{(1R,1'S)-1,1'Ferrocen-2,4-dien-1-yl-2,2'-diyl bis [(Z)methyl-ylidenenitrilo]}bis(3-iodophenol)] have been prepared and characterized by elemental analysis, magnetic susceptibility, Conductivity IR, UV-Visible, Mass spectra and TGA/DTA. Organometallic Sc...
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PREVALENCE OF PATHOGENIC ORGANISMS IN MEAT SAMPLES OF ONGKHARAK NAKHONNAYOK THAILAND
Globally, foodborne pathogens are the origin of diseases and deaths. To prevent the foodborne pathogens billions of dollars spending. Coliforms level, psychrotrophs mesophiles, E. coli, and Staphylococcus aureus, are routinely assessed to determine microbial safety, sanitation conditions, improper hygiene in poultry carcasses. Thai-population consumes more broiler meat due to its availability and ...
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FORMULATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE FLOATING TABLETS OF LAMIVUDINE
The aim of the present work is to increase the gastric residence time of Lamivudine by preparing it into gastro retentive floating tablets whereby making it available at its site of absorption and to achieve an extended action for a time period of 24hrs and to reduce the dosing frequency to once a day, using release retardant polymers METHOCEL, POLYOX and CARBOPOL. The compatibility of the drug wi...
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MOLECULAR DOCKING STUDIES OF BMS-378806 ANALOGS AS NOVEL HIV-1 GP120/CD4 INHIBITORS
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 recep...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF RITONAVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A simple, precise, specific and accurate reverse phase HPLC method has been developed for the determination of Ritonavir in bulk and pharmaceutical dosage forms. The chromatographic separation was achieved on Symmetry C18 (4.6 x 100mm, 3.5 μm) column using a mixture of Buffer: Acetonitrile (50:50) as the mobile phase at a flow rate 1.0 ml/min. Linearity was observed in concentration range of 50-1...
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CHARACTERIZATION OF ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF METHANOLIC EXTRACTS OF DIFFERENT PARTS OF AEGLE MARMELOS (L.)
Aegle marmelos(L.), family rutaceae is highly reputed medicinal tree commonly known as the bael. All parts of the plant have medicinal properties and extensively used by the traditional medicine practitioners of Bangladesh in different health ailments like Diabetes, Diarrhea, Jaundice, typhoid. The present study was dedicated to investigate phytochemical and pharmacological properties of ripe frui...
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FORMULATION AND DEVELOPMENT OF BOSENTAN LOADED ONCE A DAILY TABLET FOR PULMONARY ARTERY HYPERTENSION USING LIPID MATRICES BY 32 FULL FACTORIAL DESIGN
To avoid problems of conventional therapy of drug delivery and reduced dose, sustained release matrix tablet of Bosentan was prepared using lipid base material as matrices. Primary screening of polymer was done by selecting different lipid base materials like Compritol 888 ATO, Precirol ATO 5, Eudragit RSPO, Glycerly monostearate (GMS) and cetosteryl alcohol. All the batches were prepared by direc...
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DISPERSIBLE FORMULATION MAKEUPS FOR PEDIATRIC USE: A REVIEW
Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature show...
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MULTIPLE SCLEROSIS: A REVIEW
Multiple sclerosis affects around 2.5 million people worldwide it is one of the most common neurological disorders and cause of disability of young adults, especially in Europe and North America. There is a lack of epidemiological studies from Asia where the prevalence is reported to be low, though, with the availability of more neurologists and magnetic resonance imaging, a larger number of patie...
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