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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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40.

OPTIMIZED FORMULATION OF VANCOMYCIN LOADED THERMOREVERSIBLE HYDROGEL FOR TREATMENT OF ORTHOPEDIC INFECTIONS

The aim of the present study was to develop suitable controlled release injectable vancomycin thermoreversible chitosan/ β-glycerophosphate hydrogel system for treatment of orthopedic infections. The effect of different formulation variables on the gelation temperature was studied. The prepared vancomycin loaded Chitosan/β-glycerophosphate thermoreversible hydrogels were characterized regarding ...

Hend Mohamed Abdel-Bar, Amal Youssef Abdel-Reheem, Rihab Osman*, Gehanne A.S. Awad and Nahed Mortada

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(7).2936-46

2936-2946

4172

2140

10.

VASORELAXATION EFFECT PROMOTED BY THE CALCIUM CHANNEL BLOCKER VERAPAMIL COORDINATED TO RUTHENIUM (II): CHEMICAL AND BIOLOGICAL PROPERTIES

This paper presents the synthesis and physical-chemical characterization of a new terpyridine (tpy) ruthenium complex coordinated to the L-type calcium blocker channels verapamil (vera) obtained from commercial pill. Elemental analysis (%C N H), infrared (IR) and ultraviolet-visible (UV-vis.) spectroscopy, mass spectrometry (MS), and 13CNMR (nuclear magnetic resonance), and HPLC (high performance ...

O. A. Nascimento, E. F. Boffo , B. R. Silva, J. C. Biazzotto, L. M. Bendhack, R. S. da Silva and R. G. de Lima

Departamento de Química , Universidade Federal da Bahia, Avenida Barão de Geremoabo number 147 , Ondina, Salvador, BA, Brazil

DOI: 10.13040/IJPSR.0975-8232.6(9).3733-43

3733-43

4172

1776

54.

THE EFFECT OF ELICITORS ON THE PRODUCTION OF VASICINE FROM JUSTICIA ADHATODA L. CELL SUSPENSION CULTURES

In this study, α-naphthyl acetic acid and mannitol were used as elicitors to improve the productivity of useful metabolite, vasicine for archiving high concentration in Justicia adhatoda L. cell suspension cultures. When the cells were treated with 3mg 100 ml-1 suspension of α-naphthyl acetic acid,   the vasicine concentration was increased by 1.65 mg ml-1 in 15 days culture compared to untrea...

Rashmi Pa and Linu Mathew*

School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, 686 560, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3923-26

3923-3926

4171

1783

46.

FIRST AND SECOND ZAGREB INDICES AND POLYNOMIALS OF V-PHENYLENIC NANOTUBES AND NANOTORI

Let G be a simple molecular graph with vertex and edge sets V(G) and E(G), respectively. In 1972, Gutman and Trinajstić introduced the First and Second Zagreb topological indices of molecular graphs. These topological indices are useful in the study of anti-inflammatory activities of certain chemical instances, and in elsewhere. In this present study, compute the First Zagreb index Zg1(G)=  and ...

Mohammad Reza Farahani *, R. Pradeep Kumar and M. R. Rajesh Kanna

Department of Applied Mathematics, Iran University of Science and Technology (IUST) Narmak, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(1).330-33

330-333

4171

1618

42.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME METHYL 4-(1H-BENZO[d] IMIDAZOL-2-YL) PHENYL CARBAMODITHIOATE AMINE DERIVATIVES

Benzimidazole is a heterocyclic aromatic organic compound which has been an important pharmacophore and privileged structure in medicinal chemistry. Substituted benzimidazoles have considerable interest as compounds with a wide spectrum of biological activity and low toxicity. In the present study, a new series of benzimidazole thiourea derivatives are synthesize and screened for antibacterial and...

L. P. Singh*, O. P. Tiwari and Brijyog

Institute of Pharmacy, Harish Chandra P.G. College Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1194-00

1194-1200

4171

1952

18.

INDUCED COAGULATION AS A COMPLICATION OF INFLAMMATORY REACTIONS IN MICE TREATED WITH MONOSODIUM GLUTAMATE

Monosodium glutamate (MSG) is a familiar food additive processed to enhance the taste. This work was carried out to investigate the effect of MSG on platelets profile and indices of thrombus formation together with the detection of some plasma inflammatory markers. The study used adult male mice divided into five groups: a control group and four groups treated with different doses of MSG (2, 4, 8 ...

G. M. Badr * and A. I. Algefare

Department of Biological Sciences, Faculty of Science, King Faisal University, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(3).1121-25

1133-1137

4171

1485

50.

EFFECT OF HUMIC AND SALICYLIC ACIDS ON OIL YIELD AND FLAVONOID GLYCOSIDE OF SAFFLOWERS (CARTHAMUS TINCTORIUS L.) AS MEDICINAL PLANTS GROWN IN IRAQ

This study was conducted to investigation the effect of humic acid and salicylic on oil yield and flavonoids glycoside of safflower plant (Carthamus tinctorius L.) grown in Iraq. After soil preparation the plant seeds were cultivated during winter growing seeds at 2015-2017 at Karbala region, South Baghdad in Iraq. The humic acid was applied at 1000, 2000 and 4000 mg/lit conception as organic flow...

A. Kashams *, M. A. Hamza and I. S. Abbas

College of Agriculture, Karbala University, Karbala, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(5).2100-04

2100-2104

4170

1838

5.

CARBON NANOTUBES: AN APPROACH TO NOVEL DRUG DELIVERY SYSTEM

Carbon nanotubes are cylindrical carbon molecules have novel properties, making them potentially useful in many applications in nanotechnology, electronics, optics, and other fields of material science as well as potential uses in architectural fields. They have unique electronic, mechanical, optical and chemical properties that make them good candidates for a wide variety of applications, includi...

M. H. Alai*, S. P. Poptani and G.V. Patil

Radhai Niwas, Behind bus stand, A/P- Nampur, Tal- Satana, Dist- Nasik- 423204, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).329-39

329-339

4169

1679

48.

LIQUID CHROMATOGRAPHIC SEPARATION AND ANALYSIS OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL FORMULATIONS

An accurate, simple and precise RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical formulations was developed and validated. Chromatographic separation of two drugs was achieved on a Kromasil C18, (250x4.6nm, 5µm) column by using the mobile phase consisted of methanol, tetrahydrofuran and water in the ratio 55:05:40 at a flow rate of 1mL/min...

Krishna Veni P.R. , Jyothi K. Kasthuri , A. Vasu Babu , K. Vijay , G.V. Raman , I.E. Chakravarthy , B. Hari Babu*

Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur-522510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3630-34

3630-3634

4169

1659

25.

CHARACTERISATION OF ISOELEUTHERINE IN AQUEOUS EXTRACT OF ELEUTHERINE PLICATA HERB, IRIDACEAE, ACTIVE AGAINST ENTAMOEBA HYSTOLITICA/ ENTAMOEBA DISPAR IN-VITRO

Eleutherine plicata Herb., Iridaceae, is an herbaceous Iridaceae, vernacular marupazinho, largely used as tea, in the Amazonian popular phytotherapy, to treat diarrhoea alleged to amoeba infestation. To investigate the form of use of this medicinal plant andits alleged activity, and to perform a phytochemical analysis and an anti-amoebaean assay. Bulbs of the plant were dried, grinded and extracte...

M. S. Nascimento, J. M. S. Vieira , L. C. S. Malheiros, J. O. C. Silva JÚNIOR , L. C. S. Rodrigues and W. L. R. Barbosa*1

Laboratory of Phytochemistry of the Faculty of Pharmacy, Federal University of Para, Rua Augusto Correa, no. 01, CEP 66075-110, Guama, Belem, Para, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(4).1096-00

1096-1100

4168

1946