Most Popular
PROCESS VALIDATION OF SOTALOL HYDROCHLORIDE TABLETS
Process Validation is a very common term in the pharmaceutical industry. But it involves series of activities carried out in order to have the assurance that the desired quality products are manufactured. The manufacturing process need to be controlled and for this one should have sound knowledge and understanding regarding the process as well as the product. Each and every step should be scientif...
4217
2003
LIQUID CHROMATOGRAPHIC SEPARATION AND ANALYSIS OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL FORMULATIONS
An accurate, simple and precise RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical formulations was developed and validated. Chromatographic separation of two drugs was achieved on a Kromasil C18, (250x4.6nm, 5µm) column by using the mobile phase consisted of methanol, tetrahydrofuran and water in the ratio 55:05:40 at a flow rate of 1mL/min...
4217
1677
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFPODOXIME PROXETIL AND LEVOFLOXACIN HEMIHYDRATE IN COMBINED DOSAGE FORM
A simple, accurate, precise, rapid and economical RP-HPLC method was developed for the estimation of Cefpodoxime Proxetil (CPD) and Levofloxacin hemihydrate (LVX) in tablet dosage form. In Agilent – 1100/1200 Series, using C18 (250 x 4.6 mm x 5μ) column and with mobile phase composition of Phosphate buffer: Acetonitrile (pH 6.0) (50:50 v/v) at a flow rate of 1 ml/min was used. Detection was car...
4217
1676
ANTIMICROBIAL ACTIVITY OF CLEMATIS BRACHIATA THUNB LEAF EXTRACTS
The antimicrobial activity as well as phytochemical screening of the hexane, acetone, methanol and water extracts of Clematis brachiata Thunb (Ranunculaceae) leaves was investigated. The agar dilution assay method was used for the evaluation of the antimicrobial activity of extracts against 10 bacteria and four fungal species. The phytochemical screenings were performed by using the standard proce...
4215
1654
BIOMARKERS FOR THERAPEUTIC RESPONSE IN CERVICAL CANCER
Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Despite the tremendous progress that has been achieved in the screening and management of cervical cancer, there is still a need for clinically relevant prognostic biomarkers to monitor the response of patients to various therapies and to predict the chances of recurrence and recovery....
4214
1508
PUNICA GRANATUM ATTENUATES SCIATIC NERVE LIGATION INDUCED-NEUROPATHIC PAIN
The study has been designed to investigate the effect of aqueous extract of rind of Punica granatum in sciatic nerve ligation induced-neuropathic pain in rats. Surgical procedure was performed with sciatic nerve ligation to develop neuropathic pain in rats. The development of neuropathic pain was assessed by employing behaviour parameters such as hyperalgesia and allodynia. Further, the functional...
4214
1712
PROTECTIVE EFFECT OF NYCTHANTHES ARBOR-TRISTIS ON SCOPOLAMINE INDUCED AMNESIA IN RATS “A BEHAVIOURAL AND BIOCHEMICAL APPROACH”
The hydroalcoholic extract of Nyctanthes arbor-tristis (HeNAT) leaf was prepared using Soxhlet apparatus. Memory impairment (amnesia) in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time (TLT) in EPM model; escape latency time (ELT) and time spent in Q4 target quadrant (TSTQ) in MWM model. Scopolamine markedly decreased the TLT over 2 min, ELT, TSTQ over 9...
4214
1517
GENETIC VARIABILITY OF CYP2B6 G516T AND THEIR IMPACT IN EFAVIRENZ BASED HAART: A META-ANALYSIS
Background: The non-nucleoside reverse transcriptase inhibitor efavirenz is recommended as part of first-line therapy in HIV-infected patients and prescribed at a standard dose of 600 mg once daily. EFV is extensively metabolized primarily by hepatic CYP2B6 with partial involvement of CYP3A4 and CYP2A6. The aim of the study was to assess CYP 2B6 G516T polymorphism and their impact in efavirenz bas...
4213
1449
HYPER ACCUMULATION OF CADMIUM IN SOLANUM NIGRUM L. AND THEIR EFFECTS ON PHYTO-CHEMICALS AND ANTIOXIDANT ENZYMATIC ACTIVITIES
In the pot experiment, Solanum nigrum L. treated with different concentration of Cd showed high accumulation of Cd in plant. Growth of plant was not significantly affected up to ≤ 50ppm Cd treated plant, The trends of Cd accumulation in plant were leaf>shoot>root with increasing concentration of Cd and DAS. Plant accumulates 298, 92 and 58 ppm of Cd after 60DAS in leaf>shoot>root re...
4213
1829
A COMPARATIVE STUDY OF ROSIGLITAZONE AND PIOGLITAZONE TO EVALUATE THE CARDIOVASCULAR EFFECTS IN HIGH FRUCTOSE DIET INDUCED HYPERTENSIVE RATS
Thiazolidinediones (TZDs) were widely used for the treatment of type 2 diabetes. Recent studies have shown that TZDs have paradoxical effects on cardiovascular diseases. The objective of the present study was to investigate the effect of TZDs (Rosiglitazone and Pioglitazone) in High Fructose Diet (HFD) induced hypertension in rats. HFD was given for 14 weeks. After 8 weeks of hypertension inductio...
4213
1545