The present study is aimed at evaluating the in vitro antibacterial and antifungal activities of petroleum ether, chloroform, ethyl acetate, acetone, methanol, ethanol and water extracts of medicinal plant, Pyrus pashia were tested against (different gram positive and gram negative) ten bacterial strains and three fungal strains using by disc diffusion method. The different fractions of bark, frui...
Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been investi...
FORMULATION AND IN VITRO EVALUATION OF METOPROLOL SUCCINATE FLOATING TABLETS BY USING TWO VISCOSITY GRADE OF HPMC
Metoprolol is a beta1-selective (cardio selective) adrenergic receptor blocking agent used in the treatment of Hypertension. The purpose of this investigation is to improve bioavailability by preparing a gastroretentive drug delivery system. Floating tablets of Metoprolol Succinate were prepared by employing two different grades of HPMC K4M and HPMC E15M in different concentrations by effervescent...
Pelletization can be defined as an agglomeration process that converts fine powders or particles of a bulk drug and excipients into small, free-flowing, more or less spherical units, called pellets. The size of the pellets is 0.5-2mm. Pellets have the free flowing capacity and have low porosity about 10%. Preparation methods include direct pelletizing,powder layering,Suspension or Solution layerin...
Fungal infections in critically ill or immunosuppressed patients were increasing in incidence in the human population over the last 1-2 decades. There were few advances in antifungal therapy and, until recently, there were few choices from which to select a treatment for systemic mycoses. However, in the past decade, there have been several developments in this area. Antifungal agents are sufficie...
FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE
Controlled porosity osmotic tablet of metoprolol succinate prepared and evaluated in this study. Metoprolol succinate is very high soluble drug, so complete drug release obtained very fast. It is difficult to formulate osmotic tablet of Metoprolol succinate which gives drug release up to 24 hr at zero order. To get desired dissolution profile various formulation parameters like osmogen concentrati...
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. Bioavailability depends on solubility of drug. Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceutical products. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, soli...
There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action because there has been an alarming increase in the incidence of new and re-emerging infectious diseases. In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. In the present scenario of emergence of...
EVALUATION OF EXTRACTION TECHNIQUES WITH VARIOUS SOLVENTS TO DETERMINE EXTRACTION EFFICIENCY OF SELECTED MEDICINAL PLANTS
Herbal drugs play an important role in health care dynamics especially in developing countries. The key step in isolation of biologically active compounds is extraction, which is expressed as total extractive yield, yields of metabolites of interest or intensity of biological activity. Extraction of phytoconstituents from plant materials has been of tremendous interest and potential. Extractive va...
The eye is the most easily reachable organ available for topical drug delivery of local as well as interiorly acting drugs. Ideal drug delivery system aims to provide loading and maintenance dose of drug while being within therapeutic limits at the desired site of action for the desired period of time. In the treatment of ocular disease, the site of action is very narrow and undesired side effects...