Medicinal plants are a potential source of therapeutic drugs and play a central role in the health care system throughout the world. Plants have been an integral part of the life of many indigenous communities. Snakebite is a neglected tropical disease. Snakebite remains a major health concern throughout the world, especially in India. The highest Morbidity and Mortality occurs in rural and tribal...
COMPARATIVE STUDY OF ANTIULCER ACTIVITY OF METHANOLIC EXTRACTS OF WATTAKAKA VOLUBILIS (LINN.F.) STAF AND TABEBUIA ROSEA (BERTOL.) DC IN RATS
The aim of this study was to compare the antiulcer activity of methanolic extracts of Wattakaka volubilis (Linn.f.) Staf and Tabebuia rosea (Bertol.) DC in rats. The anti-ulcer effect was evaluated using Anti secretary model (chemical induced pylorus ligation). Ranitidine were used as standard drugs for ulcer studies. The extracts were administered orally at 500 mg/kg. The result of the present st...
SIMULTANEOUS ESTIMATION OF VELPATASVIR AND SOFOSBUVIR IN BULK AND COMBINED TABLET DOSAGE FORM BY A SIMPLE VALIDATED STABILITY INDICATING RP-HPLC METHOD
A Simple, sensitive, specific and stability indicating RP-HPLC method was developed for the simultaneous estimation of velpatasvir and sofosbuvir in bulk and tablet dosage form. Effective separation attained by injecting 10 μL of the standard solution containing velpatasvir and sofosbuvir into Xbrdige Phenyl (250 × 4.6 mm, 5 µ, 100 A0) column, with a mobile phase containing methanol, buffer (0....
SOCIO DEMOGRAPHIC CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MALABAR REGION OF KERALA, SOUTH INDIA
Background: Lung cancer is the most common malignant neoplasm worldwide, accounting for greater mortality than due to any other cancer. It accounts for about 13% of all new cancer cases and 19% of cancer-related deaths worldwide. In India, lung cancer comprises 6.9% of all new cases of cancer and 9.3% of all cancer-related mortality in both sexes. This study aimed to find out the socio-demographic...
DESIGN SPACE EVALUATION OF FORMULATION AND PROCESS VARIABLES OF REPAGLINIDE TRANSDERMAL THERAPEUTIC SYSTEM
Repaglinide, a blood-glucose-lowering drug, has low oral bioavailability (56 %) due to first-pass metabolism and shorter half-life (~1 hour) lead to frequent dosing to control blood glucose level. Repaglinide Transdermal Therapeutic System (TTS) was prepared to provide continuous drug delivery for a prolonged period of time. Factors affecting critical quality attributes (CQA) of Repaglinide TTS ar...
IN SILICO FINDING OF THE PUTATIVE DRUG TARGETS FROM HYPOTHETICAL SET OF PROTEINS FOR MYCOBACTERIUM LEPRAE TN
Leprosy is a chronic granulomatous disease caused by acid-fast bacilli Mycobacterium leprae. It is most prevalent in tropical countries and poses a threat to over 122 countries across the globe. In 2012, 232857 new cases of leprosy were registered in the world. World Health Organization (WHO), recommended the Multi Drug Therapy (MDT) for treatment of leprosy, but the minimum duration of treatment ...
RELATED SUBSTANCES BY HPLC METHOD FOR THE DETECTION AND EVALUATION OF IMPURITIES IN EZETIMIBE DRUG MATERIAL
The gradient HPLC method was developed to detect and quantify four related substances (FIP, FHO-2, STG-01, and desfluoro) in ezetimibe drug material. The efficient separation was carried out on Water X-Select CSH C18 column (4.6 mm × 100 mm, 2.5 μm). The impurities were separated in gradient mode of elution with 0.1% trifluoroacetic acid in water (mobile phase A) and 0.1% trifluoroacetic acid in...
PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW
Surgery, chemotherapy and radiation therapy has been the cornerstone of cancer management for decades. Since a decade or so, targeted therapies by way of Imatinib and Trastuzumab arrived that specifically target cancer cells and reply on specific molecular changes to identify them. These are in fact the standard treatment at present in several forms of cancer. But now in recent times, the fifth pi...
ELECTROCHEMICAL SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NICKEL OXIDE NANOCLUSTERS
The nanoclusters are having different properties than their bulk material. Hence, the synthesis and applications of nanoclusters of metal oxides have received more attention. Out of many available methods for the synthesis of metal oxide nanoclusters, the electro-chemical reduction method is simple, cheap, and provides pure material hence preferred. The present study describes the synthesis of nic...
EFFECT OF ACIDIC, NEUTRAL AND BASIC pH ON SOLUBILITY AND PARTITION-COEFFICIENT OF BENZOIC ACID BETWEEN WATER-BENZENE SYSTEM
Solubilization is depends on solute-solvent interaction, dissociation of solute in solvent into ionic form, temperature, pressure, hydrogen bonding, dielectric constant, polarity and non-polarity of substance, pH, etc. Partition coefficient was determined in two immiscible solvents in aqueous and organic layer. Benzoic acid was selected for present study for its solubilization in different pH buff...