Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE
The Hypoxic Ventillatory Response (HVR) at high altitude was hypothesized to cause pharmacokinetics changes, especially metabolism of drugs due to the up regulation of CYP3A4 isoenzyme. These pharmacokinetic alteration could affect pharmacotherapy, probably lead to either sub therapeutic or supra therapeutic effects. This hypothesis was studied with a pop-PK study conducted in healthy male volunte...
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EVALUATION OF PREVALENCE, KAP AND PRESCRIBING PATTERN OF DRUGS TO TYPE 2 DIABETIC PATIENTS AND ASSESSMENT OF RISK FACTORS AMONG THE NON-DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL IN SOUTHERN KERALA
A prospective, observational study was conducted among the 100 diabetic and 100 non-diabetic patients for a period of six months for the evaluation of prevalence, KAP (Knowledge, Attitude and Practice) and prescribing pattern of drugs to type 2 diabetic patients and to assess the risk factors of prevalence of diabetes among the non-diabetic patients. All information relevant to the study was colle...
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A COMPARATIVE STUDY TO EVALUATE EFFICACY, SAFETY AND COST EFFECTIVENESS BETWEEN ORAL BALOFLOXACIN VS. ORAL LEVOFLOXACIN IN PATIENTS OF ACUTE, UNCOMPLICATED URINARY TRACT INFECTION ATTENDING C. U. SHAH MEDICAL COLLEGE, SURENDRANAGAR
Objectives: To compare the efficacy, safety and cost effectiveness between oral Balofloxacin and oral Levofloxacin in acute uncomplicated urinary tract infections. Methods: Total 130 patients were enrolled for the study, out of them 119 patients completed the study. Patients were divided into two groups randomly; 63 patients received Balofloxacin 100 mg BID orally and 56 patients received Levoflox...
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EFFECTS OF BETA-ADRENOCEPTOR BLOCKERS ON THE PLATELET AND CARDIOMETABOLIC INDICES IN UNCONTROLLED HYPERTENSION
Background: Metabolic derangement in term of glucose dysregulation, dyslipidemia, and electrolyte disturbances are the adverse reactions of beta-adrenoceptor blockers that limit their use. Aims: To investigate the effect of BARBs on the cardio-metabolic risk factors and platelet indices that play a role in accelerating the atherogenicity. Materials and methods: This observational clinical study wa...
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ANXIETY DISORDERS AND HERBAL MEDICINES
Anxiety is a common and normal phenomenon, involving multiple brain regions, including amygdala, locus ceruleus and frontal cortex. Moreover, multiple brain transmitters regulate the presence and severity of anxiety; these include classical transmitters such as gamma amino butyric acid, serotonin, and dopamine, as well as neuropeptides that include corticotrophin releasing hormone, substance P, ne...
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EFFLUX PUMPS: AN OVERVIEW
Antibiotic efflux pumps appear a major component of microbial resistance to many classes of major antibiotics namely the tetracycline, the macrolides, and the fluoroquinolones. These are totally synthetic, amphiphilic compounds with no known ‘natural’ counterpart, antibiotic efflux appears sufficient per se to confer a medium or high level of resistance, defeating medically applicable treatmen...
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SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEM
Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles ...
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TGF-β INCREASES CYTOTOXIC EFFECT AND SENESCENCE INDUCED BY PI3K/ AKT/ MTOR INHIBITOR IN HUMAN COLORECTAL CANCER CELLS
Although NVP-BEZ235 and XAV-939 have been shown a promising result in the treatment of colorectal cancer (CRC), our data is little with regard to the effect of environmental cytokine on this drugs. In order to explore the reaction of CRC to this novel therapy, the current study proposes to investigate the inhibitory effect of NVP-BEZ235 and/or XAV-939 in CRC cells in combination with TGF-β as a t...
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THE BIOACTIVE POTENTIALS OF OLEA EUROPAEA SUBSPECIES AFRICANA A FOLKLORIC MEDICINAL PLANT AMONG KHOSA TRIBE IN THE EASTERN CAPE PROVINCE, SOUTH AFRICA
The dramatic increase in the burden of chronic non-communicable diseases (NCDs) in emerging economies has become a huge challenge and as such led to increased reliance on folkloric medicine for NCDs management. Consequently, wild Olea europaea leaves were assessed for medicinal potentials, as they are commonly used as a traditional therapy for these diseases in Eastern Cape, South Africa. The anti...
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ROLE OF AUTO FLUORESCENCE IN APOPTOSIS ANALYSIS OF MCF-7 AND MDA-MB231 HUMAN BREAST CARCINOMAS TREATED WITH THYMOQUINONE
Thymoquinone (TQ) is the major active component of black seed essential oil which possess encouraging effects against cancer cells. The antitumor activities of TQ were verified in breast carcinoma in-vitro and in-vivo. Most of the times, the cellular responses to apoptosis, after TQ treatment, are evaluate by flow cytometry using annexin V-propidium iodide (PI) staining method. Although flow cytom...
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