ANTIDIABETIC EFFECT OF A COMPOUND ETHANOLIC EXTRACT OF ANNONA SQUAMOSA, ECLIPTA ALBA, & BUTEA MONOSPERMA IN EXPERIMENTAL ANIMALS
Type 2 diabetes is a chronic metabolic disease that has a significant impact on the health, quality of life, and life expectancy of patients, as well as on the health care system. Exercise, diet, and weight control continue to be essential and effective means of improving glucose homeostasis. Despite considerable progress in the treatment of diabetes by oral hypoglycemic agents, search for newer d...
SYNTHESIS, MOLECULAR SIMULATION, AND ANTIOXIDANT CAPABILITY OF A NEW CLASS OF 2-PHENYL-1-BENZOPYRAN-4-ONE ON HUMAN MYELOPEROXIDASE ENZYME
The aim of the study was synthesis and characterization of 2-phenyl-1-benzopyran-4-one as a potential myeloperoxidase inhibitor. The oxidative stress was related to the generation of Reactive oxygen species (ROS), which is responsible for the enhancement of several degenerative diseases, such as osteoarthritis, cancer, diabetes, cardiovascular diseases, etc. Due to this fact, the study was targete...
N-[MORPHOLINO (4-NITROPHENYL) METHYL] NICOTINAMIDE AND ITS METAL COMPLEXES: SYNTHESIS AND EXPLORATION OF THEIR BIOACTIVITY
Synthetic organic compounds, containing relatively higher number of nitrogen attracting interest in the current medical research due to their utility in chemotherapy. The development of new medicines with more number of nitrogen atoms in their structural framework is an important challenging task for medicinal chemists. The lipophilicity of Mannich bases and their metal complexes enables them to b...
CORRELATION OF VARIATION IN THE PERCENTAGE OF COMPOUNDS RESPONSIBLE FOR MOSQUITO REPELLENT ACTIVITY IN CITRONELLA OIL OVER TIME WITH MOSQUITO REPELLENT EFFICACY OF COMMERCIAL CITRONELLA OIL SAMPLES AND SPRAYS
The control of mosquitoes, which transmit deadly diseases, has become a significant public health concern globally. Protection against mosquito bites is an important part of preventing mosquito-borne diseases. Citronella oil extracted from two types of citronella grass Cymbopogon winterianus Jowitt (Java type) and Cymbopogon nardus (L.) Rendle (Ceylon type) possess compounds responsible for mosqui...
A reliable, rapid, simple and accurate high-performance liquid chromatography method with UV detection was developed for the simultaneous quantitative determination of strychnine in a polyherbal formulation prepared from Nux Vomica. Krimimudgara rasa, a herbal dosage form containing Strychnos nux vomica, Apium graveolens, Embellia ribes, Butea monosperma in combination. Separation of the strychnin...
Osbeckia L. of Melastomataceae are unique flowering plants showing diversity in their habit and morphological features adapted to their habitats. Limited studies were recorded with the anatomy and morphology of high elevation species. The micromorphology and anatomy of vegetative and reproductive structures of seven species and three varieties of O. aspera, representing diverse habitats such as al...
The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxi...
EFFICIENT USE OF TRADITIONAL MEDICINE TO DETOXIFY UPPER REPRODUCTIVE ORGANS TOXICITY THAT MAY LEAD TO INFERTILITY
This study aims at investigating the use of herbal medicine (F. vogelii) as a natural antioxidant to detoxify reproductive toxicity. Twenty-five (25) female Wistar rats used in this research were divided into five groups of five (5) rats per group. Group A served as negative control and received feed and water ad libitum. It also received formal saline. B and C served as the low (100 mg/kg) and hi...
Human immunodeficiency virus type 1 (HIV-1), is an etiologic agent of the most life-threatening disease AIDS. HIV-1 protease (HIVP) is a key enzyme that performs an essential step in the life cycle of the virus. HIV-1 protease assembled as a dimer in the functional form and involved in cutting “polyprotein" into the proper protein-sized pieces. The two chains assemble to form a long tunnel cover...
HEPATOPROTECTIVE ACTIVITY OF BERRY EXTRACTS OF DIOSPYROS KAKI LINN. AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE MODEL
Currently, nutrition and health linkages focused on the emerging strategy of diet based regimen to combat various physiological threats including cardiovascular disorders, oxidative stress, diabetes mellitus, etc. Berry / Fruit part of Diospyros kaki Linn. was extracted using petroleum ether, chloroform, ethanol consecutively and the obtained extracts were screened for hepatoprotective activity us...