L-glutaminase [EC.220.127.116.11] is an amidohydrolase that catalyzes the hydrolytic deamination of L-glutamine, resulting in the production of L-glutamic acid and ammonia. The L-glutaminase has received a significant attention due to its potential as an anticancer agent. In the present study, soil sediments were collected from the estuaries region of Parangipettai, Cuddallore District, Tamil Nadu. The i...
ELECTROCHEMICAL DETERMINATION OF ANTI-DEPRESSANT DRUG MIRTAZAPINE EMPLOYING NAFION/f-MWCNTs COMPOSITE AT GLASSY CARBON ELECTRODE
A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the...
DEVELOPMENT AND VALIDATION OF FIRST-ORDER DERIVATIVE UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FLUVASTATIN SODIUM IN FORMULATION
A simple, accurate, precise and sensitive first-order UV - Spectrophotometric assay method has been developed and validated for the quantitative estimation of fluvastatin sodium in pharmaceutical dosage forms. The solvent to dissolve the drug and for dilutions, methanol was used. The absorption maxima of fluvastatin sodium in methanol after derivatized into the first-order derivative was found to ...
Amid the previous couple of years, the improvement of powerful, experimental innovations for treatment of cardiovascular arrhythmias has surpassed the pace at which itemized information of the basic science has aggregated. Cardiac arrhythmia is a group of conditions in which the heartbeat is irregular, either too fast, or too slow and is characterized by abnormal electrical conduction in the heart...
Buckwheat has been a major food source in Asian countries such as China, Japan, and Bhutan etc. for its nutritional values. It has been a major functional food supplement for nutraceutical industry. It is the first time exploration of buckwheat seed powder as tablet binder. The aim the study was to expand the area off tablet binders from gums and extracted polysaccharides to whole seed powders so ...
The present study explains computational methods to design 3D structure of “Cytochrome P450 4A11” of Homo sapiens enzyme using the sequence available from Uniprot (Uniprot KB - Q02928). Homology modelling study was performed to generate a 3D model of Cytochrome P450 protein. The model was developed by using Modeler 9.17 software tool. The developed model was further docked with already existin...
Andrographis paniculata (Burm. F) Nees, commonly known as the “king of bitters,” is an herbaceous plant belonging to the Acanthaceae and is found throughout tropical and subtropical Asia, Southeast Asia, and India. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant. Authors have already worked on the phytochemical investigation, analgesic and antipyretic ...
ANAL CANAL CANCER TREATMENT BY CONCURRENT CHEMORADIOTHERAPY VERSUS RADIOTHERAPY ALONE: A COMPARATIVE STUDY
Aim: The aim of this retrospective study is analysis of results of patient treatment outcome when prescribing chemotherapy and radiotherapy as concomitant setup as compared to radiotherapy alone for patients with anal canal carcinoma and related complications of this mode of treatment. Materials and Methods: 24 patients of anal canal cancer (squamous cell carcinoma-17 and adenocarcinoma-7)of me...
SYSTEMATIC REVIEW OF CLINICAL TRIALS AND PROSPECTIVE COHORTS: FOLLOW UP METHODS IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA TREATED WITH DASATINIB
Chronic myeloid leukemia (CML) is a malignancy of hematopoietic stem cells associated with a t(9;22) translocation that forms the Philadelphia chromosome and creates a novel fusion gene, BCR-ABL. For those who are resistant or intolerant to imatinib, second-generation tirosino-kinase inhibitor, as dasatinib, has been shown to be efficacious in all phases of the disease. Once dasatinib is taken ora...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF METFORMIN HYDROCHLORIDE USING AGAR AS NATURAL SUPER DISINTEGRANT
The objective of the present work is to develop orodispersible tablets of Metformin hydrochloride using agar as natural super disintegrant to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Fast dissolving drug delivery system has numerous advantages over conventional dosage form like tablet, capsule, syrups etc. Formulation of nine batches out of which b...