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FORMULATION AND IN-VITRO DRUG RELEASE STUDY OF CONTROLLED RELEASE TABLET OF NIMODIPINE
At present more than 200 oral continued/controlled/ expanded/altered discharge details are accessible in the worldwide market. In India, notwithstanding, just constrained items are financially affordable. Making a stride ahead from assembling traditional dose structures, the advancement of controlled drug delivery systems. Controlled drug delivery systems have been created to improve the following...
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PRIMARY SCREENING FOR EXTRACELLULAR ENZYME PRODUCTION, POLY-HYDROXYBUTYRATE PRODUCTION AND SALT TOLERANCE BY BACTERIA ISOLATED FROM KUTCH REGION OF GUJARAT
Gujarat has the second largest mangrove ecosystem in India, and mangrove ecosystems are known for their extreme environments and hence extremophiles that can produce novel enzymes can be found in these extreme environments. In this study, ninety-three bacterial isolates were obtained in pure cultures from soil samples collected from Kandla, Mundra and Tuna of the Kutch region of Gujarat in the win...
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ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF MERREMIA TRIDENTATA ON MURINE MODELS
The present study aims to reveal the anti-inflammatory activity of the ethanolic plant extracts of Merremia tridentata against murine models. The Wistar Albino rats of mixed sex were induced inflammation via injecting histamine and formalin. The anti-inflammatory effect of Merremia tridetata was compared with the presence of positive control, Indomethacin. The Paw volume of the control group (grou...
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FLOATING MICROSPHERES: A NOVEL EMERGING TREND IN GASTRO RETENTIVE DRUG DELIVERY
Oral Conventional dosage forms offer no control over the release of drug from the dosage form, which leads to variations in plasma drug levels; gastric emptying and gastric resident time are two another important factors that have a significant effect on the therapeutic efficacy of drug and it causes changes in the retention time of the drug. Accordingly, Floating microspheres is one of the most d...
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EVALUATION OF ANTIHYPERGLYCEMIC ACTIVITY OF THE POLYHERBAL AND ALLOPOLYHERBAL FORMULATION ON NICOTINAMIDE-STREPTOZOTOCIN-INDUCED TYPE-2 DIABETIC RATS
Amla, Arjuna, Gudmar, Guduchi, and Ginger have been usually used in the traditional system of medicine for the treatment of diabetes. The aim of the present study to evaluate antihyperglycemic activity of polyherbal and allopolyherbal formulation on Streptozotocin-Nicotinamide (STZ-NA) induced type-2 diabetes rats. All the extracts of herbs used for the present study were obtained by supercritical...
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STUDY ON A NOVEL ACTINOMYCETE, STREPTOMYCES GANCIDICUS (MF464014) AND ENHANCING ITS TANNASE PRODUCING ABILITY BY OPTIMIZING GROWTH CONDITIONS IN SUBMERGED FERMENTATION
Tannase (Tannin acylhydrolase E. C. 3.1.1.20) is a ubiquitous enzyme catalyzes the hydrolysis of ester and depside bonds of hydrolyzable tannins, releasing glucose and gallic acid. Gallic acid is used in the food industry as a substrate for the chemical synthesis of food preservatives such as gallates and pyrogallol, propyl gallate being a very important food antioxidant and in the pharmaceutical ...
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PHARMACEUTICAL POTENTIAL OF ENDOPHYTES ASSOCIATED TO MARINE SPONGE AND ALGAE FROM THE BAY OF BENGAL AND THEIR CONTRIBUTION TO THE BLUE ECONOMY OF BANGLADESH
Bangladesh is gifted with the world's largest bay, rich in untapped resources that are undeniably beneficial to human wellbeing and the national economy. However, the people of Bangladesh have not yet been capable of using the vast marine resources of the Bay of Bengal due to a lack of adequate funds and technological limitations. On the other hand, countries like Japan, China and Indonesia utiliz...
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SOLUBILITY ENHANCEMENT AND QUALITY BY DESIGN (QBD) ASSISTED FABRICATION OF FAST DISSOLVING BUCCAL FILM FOR RISPERIDONE
Rapidly Dissolving Drug Delivery Systems have become interested in the pharmaceutical industry as frameworks that provide quick onset of action with enhanced dissolution characteristics. Risperidone, a poorly water-soluble drug, is a second-generation antipsychotic of the benzisoxazole derivatives used in treating schizophrenia and other mood disorders. The present research work aimed to fabricate...
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A REVIEW ON ACETYLCHOLINESTERASE INHIBITING THERAPEUTICS AND RECENT BREAKTHROUGHS IN THE FIELD OF ALZHEIMER`S DISEASE
Alzheimer's disease (AD) is one of the most well-studied neurodegenerative conditions. It is a debilitating chronic disease of the central nervous system (CNS). Almost 131.5 million individuals are predicted to be affected by the disease by 2050. The main effects of AD are cognitive decline and language problems. One of the factors contributing to AD is the gradual decrease in the brain's concent...
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SAGA OF GASTRORETENTIVE DRUG DELIVERY SYSTEM: EMERGING CONCEPTS, RECENT ADVANCES AND TECHNOLOGICAL PROGRESS
Oral controlled release and site-specific drug delivery systems have gained interest in the pharmaceutical industry to improve the treatment of certain critical medications. To overcome physiological barriers, such as short stomach resident lengths and variable gastric emptying periods, the idea of a novel drug delivery mechanism evolved. To improve the bioavailability of drugs with narrow therape...
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