Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
EVALUATION OF MYCOPLASMA HOMINIS PROTEOME TO IDENTIFY THE POTENTIAL VACCINE CANDIDATE PROTEINS
Objective: Mycoplasma hominisis a gram-negative bacteria belonging to class Mollicutes that is commonly present in men and women of reproductive age. At present, there is no effective prophylaxis for Mycoplasma hominis, as it has gained resistance for the drugs hence an in-silico approach was undertaken to find out the peptide-based vaccine for the pathogen. Methods: In women, it affects the genit...
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METHOD DEVELOPMENT AND VALIDATION OF LC-ESI-MS/MS TECHNIQUE FOR THE ESTIMATION OF MODAFINIL IN HUMAN PLASMA; APPLICATION TO PHARMACOKINETICS IN HEALTHY RABBITS
A new simple and sensitive liquid chromatography-electrospray ionization-tandem-mass spectrometric (LC-ESI-MS/MS) technique was developed and validated for the estimation of modafinil in human plasma and the method was applied to study pharmacokinetics in healthy rabbits. Chromatography was attained on Phenomenex- C18 (50mm × 4mm) 5µ column and acetonitrile, methanol and 0.1% formic acid (25:60:...
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COMBINED ANTICONVULSANT EFFECT OF NIFEDIPINE AND PENTAZOCINE IN EXPERIMENTALLY INDUCED CONVULSIONS BY ELECTRO CONVULSOMETER IN MICE AND RATS
The present study aimed to investigate the combined anticonvulsant effect of nifedipine (calcium channel blocker) and pentazocine (opioid analgesic) on the duration of convulsions, tonic hind limb extension and recovery in mice and rats. The study was initiated after obtaining ethical approval from the Institutional Animal Ethics Committee (IAEC), Department of Pharmacology, Osmania Medical Colleg...
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PHYTOCHEMICAL ANALYSIS AND IN-VITRO ANTI-OXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT FROM TENDER COCONUT MESOCARP
Free radicals are responsible for the development of many diseases. Anti-oxidants play an important role in scavenging free radicals. Anti-oxidant activity of herbal extracts and isolated compounds are reported earlier. Pharmaceutical industries are carrying out research in the development of new potent antioxidants. Novel drug development from economically cheapest plant waste might be useful for...
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STUDY OF VARIATION IN ELECTROCHEMICAL BEHAVIOUR OF FURAZOLIDONE AND METRONIDAZOLE SIMULTANEOUSLY BY DIFFERENTIAL PULSE VOLTAMMETRY
In present study, a successful attempt has been made to study the variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 4.25. Both Furazolidone and ...
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ENVIRONMENTAL WELLNESS WITH SPECIAL REFERENCE TO HAEMATOZOAN INFECTION IN REPTILIAN HOSTS
Environment provides a solid platform for good health. An unhealthy environment makes place unsafe for wild animals. One of the effects is a parasitic load on these animals, as a high degree of parasitization may cause harm to the health of these animals. In the present research work, blood parasitic infestation in two species of lizards, Hemidactylus flaviviridis and Calotes versicolor were inves...
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A STUDY ON EFFECT OF THERMAL SINTERING ON GASTRIC FLOATING TABLETS
The purpose of this study was to develop a gastroretentive controlled release drug delivery system using sintering for enhanced oral bioavailability using carnauba wax polymer. Formulations (CC1-CC3) were prepared by wet granulation method and then exposed to sintering temperature at different time intervals. The optimized formula showed zero-order drug release kinetics for the period of 12 h. The...
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EVALUATION OF ANTIGENOTOXIC POTENTIAL OF BEET ROOT EXTRACT AGAINST HAIR DYE INDUCED GENOTOXICITY
In-vitro investigations toward DNA damage reported that the biological effect of genotoxic exposures could influence the life cycles of different human cells. Sister chromatid exchange (SCE) assay is broadly used, sensitive cytogenetic biomarker of exposure to genotoxic agents. Naturally available products may play a significant role against the cytogenetic damage but available research data is no...
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DESIGN AND EVALUATION OF CIPROFLOXACIN FLOATING TABLETS USING THERMAL SINTERING TECHNIQUE
The main of this study was production of floating tablets to maintain the drug stay in its absorption area. Ciprofloxacin is better absorbed in the stomach because of this reason floating matrix tablet was prepared using novel sintering technique with sodium bicarbonate as gas generating agent and a polymer eudragit robust formulation was decided on the basis of floating time and in-vitro drug rel...
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THE IN-VITRO ANTI-DENATURATION EFFECTS INDUCED BY SUBSTITUTED OXY/THIOXY PYRIMIDINE DERIVATIVES IN BOVINE SERUM ALBUMIN IS PROPOSED AS A SCREENING ASSAY FOR THE DETECTION OF ANTI-INFLAMMATORY COMPOUNDS WITHOUT THE USE OF ANIMALS
A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine s...
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