Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES ON NOVEL CINNOLINE DERIVATIVES AS POTENTIAL ANTITUBERCULOSIS AGENTS
The emerging need for the multidrug regimen of M. tuberculosis strains urged us to synthesize novice and potent anti-tubercular medicaments. Our interest in this work had afforded a series of novice cinnolines as a new structural category of antituberculosis agents. All 14 compounds were synthesized using the appropriate scheme, two-step reactions with the high yielding product. The newly synthesi...
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FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE FILMS OF ZOLMITRIPTAN
Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research zolmitriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive fil...
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DAPAGLIFLOZIN: AN ANTI-DIABETIC DRUG WITH CARDIOVASCULAR BENEFITS
Type 2 diabetes mellitus (T2DM) is a chronic disease, and most patients ultimately require two or more anti-hyperglycemic drugs along with lifestyle changes to achieve and maintain glycaemic control. Sodium-glucose co-transporter 2(SGLT2) inhibitors, such as Dapagliflozin, are the newest class of antidiabetic drugs approved for the treatment of T2DM. Dapagliflozin is a highly selective SGLT2 inhib...
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CHRONOPHARMACOLOGY: THE BIOLOGICAL CLOCK
Chronopharmacology is the science that is of different types in the pharmacological activities of different treatment over organic timings and endogenous balance. Chronotherapeutics is the science which increases the creativity and security of prescriptions by balancing their fixations during the 24 h synchronizing with regular routine determinants of disease. Chronopharmacokinetics again manages ...
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SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY AQUEOUS SOLUBLE DRUG GEFITINIB BY SELF EMULSIFYING DRUG DELIVERY SYSTEM
The present research work was aimed at the enhancement of solubility and dissolution rate of Gefitinib by Self Emulsifying Drug Delivery Systems (SEDDS). Gefitinib is a BCS class II drug with poor aqueous solubility (oral bioavailability 60%). The saturated solubility of Gefitinib in different oils, surfactants and co-surfactants were determined. The excipients were screened and selected showing m...
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SPHERICAL CRYSTALLIZATION OF SITAGLIPTIN PHOSPHATE MONOHYDRATE FOR FORMULATION OF DIRECTLY COMPRESSIBLE TABLETS
Sitagliptin was invented in 2006 as a DPP-4 inhibitor. It is soluble in water to the extent of 0.03 mg/mL as thus suffers bioavailability problems. It was converted into phosphate monohydrate salt with solubility 50 mg/mL, which solved bioavailability problems. In this research, an attempt is made to convert it from its crystalline form into spherical crystals. Spherical crystals have better bulk ...
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INJECTION SITE REACTION TO REPEATED INTRAVENOUS BOLUS INJECTION OF DICLOFENAC SODIUM IN TAIL VEIN OF WISTAR RAT
Diclofenac is the most popular and widely prescribed non-steroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sod...
1984
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PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF HEXANOLIC EXTRACT OF LANTANA CAMARA LINN.
Lantana camara Linn. is an important ethnomedicinal plant with several medicinal properties. It is widely used in the traditional medicinal system as carminative, anti-inflammatory, antipyretic and respiratory system infections. The present investigation was carried out to determine the qualitative analysis of phytochemical screening and the presence of bioactive compounds from the hexanolic extra...
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STABILITY INDICATING LC-ASSAY METHOD FOR METFORMIN HYDROCHLORIDE AND TENELIGLIPTIN HYDROBROMIDE FROM TABLET FORMULATIONS
A simple, rapid, accurate, robust, and specific HPLC method was developed for the assay of metformin hydrochloride and teneligliptin hydrobromide from the oral tablet formulations. Stability-indicating reverse-phase chromatographic method was developed on a RP C18 column (250 mm × 4.6 mm, 5µm) using a mixture of 20 mM ammonium acetate of pH 5.5 and methanol in the ratio 50:50 v/v as mobile phase...
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FORMULATION AND EVALUATION OF LINAGLIPTIN BUCCAL ADHESIVE TABLETS FOR TYPE-II DIABETES
Last few decades, the remarkable advancement in the drug delivery system has been done; the oral route remains the importance and picks up the safest route of drug delivery. Regardless of striking advancements in the oral route medication, the current study focused on the formulation of a linagliptin buccal adhesive tablet. Formulated tablets are containing linagliptin as an active drug with a com...
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