Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
EFFECT OF ANTI-DIABETIC DRUGS ON SERUM B12, MINERALS LIKE ZINC, MAGNESIUM, PHOSPHORUS AND CALCIUM IN TYPE II DIABETES MELLITUS (T2DM)
Metformin, the first-line drug, can reduce hepatic gluconeogenesis and increase insulin sensitivity. At the molecular level, metformin inhibits the mitochondrial respiratory chain, which leads to an increase in adenosine monophosphate-activated protein kinase, which increases insulin sensitivity. Recent guidelines advocate metformin as the first-line agent that has a glucose-lowering effect concur...
1973
851
PHYTOCHEMICAL STUDIES AND QUANTIFICATION OF TOTAL PHENOLS, TANNINS AND FLAVONOIDS IN LESS KNOWN SEMI-ARID PLANTS OF BALLARI, KARNATAKA
Four plant species Senna italica, Prosopis juliflora, Cressa cretica and Schouwia purpurea were selected to estimate phytoconstituents and quantify total phenols, tannins, and flavonoids. The total content of phenols, tannins, and flavonoids with the gallic acid curve by the standard method was estimated. The leaf extract of Senna italica contained maximum, and Schouwia purpurea contained a minimu...
2140
1074
SCREENING FOR BIOFILM-FORMING EFFICACY OF CLINICAL ISOLATES
Seven pathogenic isolates with clinical history were procured from the Department of Microbiology, RMMCH, Annamalai University, Chidambaram, Tamil Nadu. Among them, five isolates (S1-S5) showed multi-drug resistance to the selected antibiotics. Maximum multi-drug resistance was exhibited by four Gram negative isolates (S1, S2, S4 and S5). Initial qualitative analysis of these four isolates for bio...
1664
785
TOXICOLOGICAL EVALUATION OF TRIVANGA BHASMA (TRIMETALLIC AYURVEDIC FORMULATION) IN ANIMAL MODEL VIA 28-DAY REPEATED ORAL DOSE
Context: Ayurveda emphasizes applying herbal, metallic, mineral, and herbo-mineral preparations in therapeutics. Trivanga Bhasma (TB) is a potential trimetallic (Tin, Lead & Zinc) compound formulation widely used in routine Ayurvedic practice to treat several chronic ailments. Objective: To elucidate the toxicity profile of TB by oral administration in wistar albino rats to ascertain the safet...
2010
859
IN-VIVO EVALUATION OF GLICLAZIDE SOLID DISPERSIONS INCORPORATED TABLETS FOR CONTROLLED DRUG RELEASE
Gliclazide is an anti-diabetic medication used to treat diabetes mellitus type 2.It suffers from deprived solubility, reduced drug dissolution, and bioavailability. The current paper is aimed to formulate and evaluate gliclazide solid dispersion with HP β Cyclodextrin for enhanced solubility and incorporate into controlled-release tablet formulation. Gliclazide solid dispersion (SD) was prepared ...
1836
966
A REVIEW ON THE MITOCHONDRIAL DYSFUNCTION IN SPORADIC PARKINSON’S DISEASE
Parkinson’s disease is the second most common progressive, age-linked neurodegenerative disorder. The sporadic form of the disease is usually idiopathic, where mitochondrial dysfunction is its major hallmark. Mitochondria are multifunctional dynamic organelles that carry out major cellular functions that get damaged by reactive oxygen species, deposition of lewy bodies, dopaminergic neuronal cel...
2293
1196
REVIEW ON ACTIVITY OF CANNABIS TREATMENT ON PARKINSON’S DISEASE
As new treatments and medication are growing rapidly, neurologists are also toward expanding treating patients with idiopathic Parkinson's disease and facing questions regarding cannabis as a treatment elective, particularly for levodopa-safe Parkinson's symptoms. Cannabinoids compounds like delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are the most abundant chemicals present. Whereas T...
2116
1081
SCREENING MODELS OF ANTI-PARKINSONIAN AGENTS
Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hen...
3978
2073
OROXYLUM INDICUM: AN OVERVIEW
Oroxylum indicum (O. indicum), commonly known as the Indian trumpet tree, belonging to the family Bignoniaceae, is a medicinally important, small, or medium-sized plant used to treat various diseases and also has its importance in the traditional system of medicine. Various parts of the plant have been proved to possess useful pharmacological activities. It is native to the Indian subcontinent, ex...
3942
2579
A SYSTEMATIC REVIEW ON DRUG REPOSITIONING: A NEW METHODOLOGY TO DRUG DISCOVERY
At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently...
2044
1000