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ANTIMUTAGENIC ACTIVITY OF POMEGRANATE EXTRACT AND 2 – METHOXY-ESTRADIOL IN COMBINATION ON SWISS ALBINO MOUSE – MUS MUSCULAS
Pomegranate extracts (PGEs) exhibit antioxidative, antiproliferative, and antineoplastic activities. 2-Methoxyestradiol (2-ME), the end metabolite of 17β estradiol (E2), an antiangiogenic agent, inhibits tumor growth. Our earlier investigations demonstrated that aqueous PG extract (PGE) in combination with 2-ME showed antineoplastic effect on Sarcoma-180 tumor cells. The present paper has been or...
1948
1066
AN OUTLINE OF QUALITY GUIDELINES FOR DEVELOPING AND VALIDATING ANALYTICAL PROCEDURES
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while co...
1948
2020
REVIEW ON ORIGIN AND CONCATENATION OF COVID-19
Since 2019-November on world facing whole world is facing an unprecedented health problem. The WHO has said that a pandemic infection are coming with a new virus species of coronavirus is called SARS-CoV-2. Coronavirus 2019 is associated with global health and acute coronary respiratory syndrome coronavirus-2. COVID-19 is widely spread through drip channels. The virus causes mild symptoms in many ...
1946
917
ISOLATION, IDENTIFICATION AND SCREENING FOR BIOACTIVE COMPOUNDS WITH ANTIMICROBIAL ACTIVITIES FROM SUB-AERIAL CYANOBACTERIA OF EASTERN REGION, ODISHA
Background and Objectives: Cyanobacteria are rich in various bioactive compounds. This study aims to screen the antimicrobial activity of sub-aerial Cyanobacteria isolated from sub-aerial habitats (Old monuments and building facades). Materials and Methods: Crude aqueous and organic extracts were screened for phytochemical constituents and tested for their antimicrobial efficacy against human path...
1946
1021
FORMULATION AND EVALUATION OF QUINAPRIL EXTENDED-RELEASE TRILAYERED MATRIX TABLETS BY DESIGN OF EXPERIMENT
Objective: The present research was focused on designing, formulate and evaluate the trilayer matrix tablets incorporated with quinapril for extending drug release. Methods: Quinapril trilayer matrix tablets were formulated using response surface methodology wherein initially 27 formulations (QF1-QF27) were designed for active layer from which one best formulation was chosen based on drug content,...
1945
1073
CHARACTERIZATION OF BIOLOGICALLY ACTIVE FRACTIONS OF METHANOL EXTRACT OF MATURE LEAVES OF POGOSTEMON BENGHALENSIS (BURM. F.) KUNTZE AND PERILLA FRUTESCENS (L.) BRITTON
The aim of the study was to determine the biologically active fractions of methanol extracts of mature leaves of Pogostemon benghalensis (burm. f.) Kuntze and Perilla frutescens L. Britton. The methanol extract was broadly fractionated sequentially in hexane, chloroform, acetone, ethyl acetate, and methanol. Activity index was recorded higher in methanol broad fractions of both of the plants. Broa...
1945
1156
EVALUATION OF ANTI-ALZHEIMER ACTIVITY OF ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES IN WISTAR ALBINO RATS
Alzheimer's (AD) has been the most prevalent kind of dementia, generally producing linguistic and visuospatial deficits, frequently combining comfort ability problems such as apathy, aggression and depression, via the gradual deterioration of the episodic memory and learning. A noteworthy pathophysiological cause is the presence in the neuronal cytoplasm of extracellular plaque of insoluble ß-amy...
1945
1258
PREPARATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF BERBERINE LOADED NANOEMULSION FOR ENHANCED ANTIMICROBIAL EFFICACY
Aim: The current research aimed to formulate and evaluate herbal nanoemulsion of poorly soluble Berberine hydrochloride, which can provide a realistic alternative for treating microbial infections. Materials and Methods: The drug was characterized using various analytical techniques such as Ultraviolet Spectroscopy, Fourier transform infrared spectroscopy, and Differential Scanning Calorimetry s...
1945
1688
FORMULATION DEVELOPMENT AND EVALUATION OF POLY AMIDOAMINE (PAMAM) DENDRIMERS AS POTENTIAL CARRIERS FOR ENHANCED TRANSDERMAL DELIVERY OF ITRACONAZOLE GEL FORMULATION
The drug of dendrigel, uses dendrimers as medicine carriers. Dendrimers were prepared by divergent growth techniques and were loaded in varying quantities in carbapol 934. To this mixture, itraconazole drug was added and the expression of dendrigel was estimated. Dendrimers were prepared by divergent growth techniques. Estimation parameters like color test, UV spectroscopy, and FTIR. Evaluation pa...
1944
1180
DESIGN, GREENSYNTHESIS AND MOLECULAR DOCKING STUDIES OF A NOVEL 2,4,5- TRIPHENYL IMIDAZOLE DERIVATIVE
The design and synthesis of a novel 2,4,5- Triphenyl imidazole derivative has been achieved using a green chemistry approach. These compounds were synthesized by using a sustainable catalytic material and solvent free one-pot reaction where benzil, aromatic aldehydes, ammonium acetate and acid chloride were reacted under microwave irradiation. This method offers several advantages including simpli...
1943
1106