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A COMPARATIVE INVESTIGATION OF METHANOL AND SILVER NANOPARTICLES EXTRACTION FROM CORIANDRUM SATIVUM SEEDS FOR ANTIDIABETIC POTENTIALITY – IN-VITRO
Botanical name of coriander is Coriandrum sativum Linn. Coriandrum sativum belongs to the family Umbelliferae which is a highly reputed ayurvedic medicinal tree commonly known as Dhania. Essential oils, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum so far. The phytochemical analysis of both methanol and AgNP’s extract was evaluated. Results revealed t...
1899
1103
HYPOGLYCEMIC ACTIVITY PROFILE OF POLYHERBAL FORMULATION (PF) AND POTENTIATION OF HYPOGLYCEMIC EFFECT OF METFORMIN IN RODENTS
Polyherbal formulation (HF) containing different herbs have been used to treat diabetic patients by ayurvedic practitioners in India. The present study reports the effect of HF alone and with metformin on different rat models of hyperglycemia. HF treatment with HF alone and in combination with metformin elicited a significant hypoglycemic effect on epinephrine hyperglycemia and alloxan diabetic ra...
1898
964
ANTIDIARRHOEAL EFFECT OF CASUARINA EQUISETIFOLIA ON EXPERIMENTAL ANIMALS
Current investigation was to evaluate antidiarrhoeal effect of Casuarina equisetifolia. Anti-diarrhoeal activity of methanol bark extract of Casuarina equisetifolia (CEME) studied on experimentally induced diarrhea in rats, castor oil-induced diarrhoea & enteropooling, meal transit time, and PGE2-induced entropooling. The CEME orally administered at doses 100, 200, and 400 mg/kg/atropine 0.1 m...
1897
931
FUNCTIONALIZATION OF POLYSACCHARIDES-VERSATILE STRATEGIES AND THEIR APPLICATIONS
Polysaccharides are composed of monosaccharide’s linked by glycosidic bonds. These are abundantly available and are obtained from renewable resources. Polysaccharides provide an array of primary structures and conformations used in the pharmaceutical industry. Natural polysaccharides properties can be substantially modulated by chemical, physical, and enzymatic modifications and have received in...
1896
1379
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-UFLC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND METFORMIN HCl
A Simple, sensitive, precise, and stability-indicating method was developed for the simultaneous estimation of Telmisartan & Metformin HCl in bulk & prepared formulation. The column used for the separation was Phenomenex C18 (150 × 4.6, 5 µ), with a mobile phase containing Phosphate buffer pH 3.6 & acetonitrile (30:70% v/v) at a flow rate of 0.5 ml/min. The retention time of Telmisar...
1896
940
STRUCTURAL AND FUNCTIONAL ABNORMALITIES ASSOCIATED WITH HIGH FRUCTOSE DIET-INDUCED METABOLIC SYNDROME IN WISTAR ALBINO RATS
Purpose of the study: To assess Structural and functional abnormalities associated with High fructose diet-induced Metabolic syndrome in wistar albino rats. Materials and Methods: Metabolic syndrome is induced in adult male Wistar albino rats by feeding a combination of High Fructose Diet (55%) and Fructose enriched water (15%) for 75 days and kept as group 2 or HFrD Group. Normal male Wistar albi...
1895
908
ANTIGENOTOXIC EFFECTS OF SILYMARIN AGAINST NICKEL CHLORIDE MEDIATED DNA DAMAGE IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES
DNA damage induced by Nickel chloride in lymphocytes has been studied in-vitro. The sister chromatids exchange and single-cell gel electrophoresis (SCGE), or comet assay were used to measure the level of DNA damage in terms of SCE frequency and comet parameters. Silymarin is a natural protective compound, isolated from Silybum marianum seeds and reported for its anti-genotoxic properties. In this ...
1895
835
PLANT MOLECULAR PHARMING: THE FUTURE OF PHARMACEUTICAL BIOTECHNOLOGY
Plants are the natural sources of a vast diversity of molecules, exploited for the benefit of human health. They are the factories synthesizing proteins, carbohydrates, secondary metabolites, and biopolymers. Further, converting these molecules into antioxidants, pharmaceuticals, food, and biofuels is a major industrial process. Plants are becoming significant sources for producing pharmaceuticall...
1895
1733
IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....
1895
1192
SEASONAL FLUCTUATIONS IN ARBUSCULAR MYCORRHIZAL FUNGAL COMMUNITIES: A REVIEW
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heav...
1894
1294