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ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS USED BY THE DIFFERENT TRIBAL COMMUNITIES IN NILAKH- SRIPANI AREA OF DHEMAJI DISTRICT, ASSAM
Due to plentiful wild plant diversity, poor road conditions to connect modern medical facilities, and age-old folk knowledge on medicinal plants, the tribal communities of Dhemaji District, Assam, India, still practice traditional plant-based therapy in the management of primary healthcare. The present investigation aims to represent the ethnobotanical knowledge of different ethnic community peopl...
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PRECLINICAL SAFETY EVALUATION OF BERBERINE IN COMBINATION WITH GLICLAZIDE
Allopathic drugs are generally prescribed for Diabetes Mellitus (Type-II) patients. As the disease is chronic in nature, it necessitates the use of alternative medicine(s) either to supplement the existing allopathic therapy and/or to reduce the associated side effects with their chronic use. The use of herbal drugs is presumed to be safe option due to fewer side effects. However, evaluation of sa...
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HISTOLOGICAL AND PHYTOCHEMICAL ANALYSIS OF FOUR ETHNOMEDICINAL PLANTS USED TO CURE SKIN DISEASES
Natural plant-derived compounds have been an essential resource in the evolution of drug discovery since the dawn of time. Using plants as a source of medicine is a century-long-standing tradition not merely in India but also in the entire world. North-East India is bestowed with incredible biological richness. The current research is focused on the histological and phytochemical analysis of four ...
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ELLAGITANNIN EXTRACTED FROM PLANT EUPHORBIA PROSTRATA CLAIM MEMORY ENHANCING ACTIVITY
Human memory can store and recall previously learned information to be applied for the routine purpose. Memory disorders caused by diseases can have an impact on an individual's quality of life as well as their overall cognitive abilities. Memory disorders are associated with the alteration in cholinergic neurotransmission. The herbal extract of Euphorbia prostrata was found to be used traditional...
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LIPID PROFILE AND BLOOD GLUCOSE LEVELS OF ALLOXAN-INDUCED DIABETIC RATS TREATED WITH AJỤ MBAISE POLYHERBAL FORMULATION
Ajụ mbaise polyherbal extract, widely consumed for medicinal and nutritional purposes is composed of stems, leaves, roots and barks of different plant species wrapped together in various proportions. The current study was carried out to determine the effects of orally administered ethanolic Ajụ mbaise polyherbal extract on lipid profile and blood glucose levels of alloxan-induced diabetic ra...
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DESIGN AND DEVELOPMENT OF MODIFIED RELEASE TABLET BY MIXED SOLVENCY ASSISTED SOLID DISPERSION OF VALSARTAN
In the present investigation, newly developed solid dispersion technology that precludes the use of organic solvent and decreases the individual concentration of hydrotropic agents, simultaneously decreasing their toxic potential, was employed for preparing dispersions of valsartan. Valsartan is a pro-drug which has poor bioavailability because of poor solubility as it belongs to BCS class II. Stu...
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IN-SILICO ANALYSIS OF GALLIC ACID DERIVATIVES FOR IDENTIFICATION OF NOVEL ALANINE RACEMASE INHIBITORS
Background: In drug design development, Alanine racemase grabbed researchers' attention as it is a potential target for many antimicrobial agents due to its imperative role in bacterial cell wall synthesis. The irresponsible binge eating of antibiotics leads to drug resistance is a key issue of concern for the researchers. The development of multidrug resistance, responsible for causing immense hu...
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NOVEL INDOLE DERIVATIVES AS A PROMISING SCAFFOLD FOR THE DISCOVERY AND DEVELOPMENT OF POTENTIAL BIOLOGICAL ACTIVITIES: AN OVERVIEW
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple r...
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KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS ANTIBIOTIC USE AND ANTIBIOTIC RESISTANCE AMONG MEDICAL STUDENTS: A CROSS-SECTIONAL STUDY
Background: Injudiciously use of antibiotics / antimicrobial agents poses a major public health threat worldwide. Medical students will be future prescriber of antimicrobial agents so they need to have a wide awareness of the use and resistance of antibiotics. Therefore, this study was planned to assess the Knowledge, Attitude and Practice (KAP) toward antibiotics usage and antibiotics resistance ...
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FORMULATION DEVELOPMENT OF ORAL FAST-DISSOLVING SUBLINGUAL FILM OF RESVERATROL
This research aimed to develop an inclusion complex of resveratrol (RSV)/hydroxypropyl-β-cyclodextrin (HP-β-CD) using a quality-by-design (QbD) approach to improve the solubility and stability of RSV and formulate it into a fast-dissolving sublingual film (FDSF). The RSV/HP-β-CD inclusion complex was prepared by the kneading method using a Box–Behnken Design to assess the effect of the molar ...
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