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HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE IN-VITRO INTERACTION STUDY OF MEBENDAZOLE WITH ATORVASTATIN
By the HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280 nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ± 0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intra...
1905
1054
ISOLATION, IDENTIFICATION AND SCREENING FOR BIOACTIVE COMPOUNDS WITH ANTIMICROBIAL ACTIVITIES FROM SUB-AERIAL CYANOBACTERIA OF EASTERN REGION, ODISHA
Background and Objectives: Cyanobacteria are rich in various bioactive compounds. This study aims to screen the antimicrobial activity of sub-aerial Cyanobacteria isolated from sub-aerial habitats (Old monuments and building facades). Materials and Methods: Crude aqueous and organic extracts were screened for phytochemical constituents and tested for their antimicrobial efficacy against human path...
1905
1006
FORMULATION AND EVALUATION OF QUINAPRIL EXTENDED-RELEASE TRILAYERED MATRIX TABLETS BY DESIGN OF EXPERIMENT
Objective: The present research was focused on designing, formulate and evaluate the trilayer matrix tablets incorporated with quinapril for extending drug release. Methods: Quinapril trilayer matrix tablets were formulated using response surface methodology wherein initially 27 formulations (QF1-QF27) were designed for active layer from which one best formulation was chosen based on drug content,...
1904
1055
IN-VITRO ANTI-OXIDANT ACTIVITY OF ELYTRARIA ACAULIS
The overproduction of oxidants in the body leading to different side effects and chronic diseases, including oxidative stress. The oxidative stress is the overproduction of the oxidant's condition in the body, which leads to metabolic imbalance and leading to diseases. It is one of the main diseases around the world, affecting the human lifestyle, either psychologically and physically. The natural...
1904
922
ANTIOXIDANT AND ANTIMICROBIAL POTENTIALS OF THE EXTRACTS OBTAINED FROM THE FIVE MARINE SPONGES COLLECTED OFF THE COASTS OF AGUSAN DEL NORTE, PHILIPPINES: AXINYSSA SP, PLOCAMIONIDA SP, FORCEPIA SP, PACHYMATISMA SP AND PLACOSPONGIA SP
Five marine sponges were collected off Carmen, Agusan del Norte, Philippines and taxonomically identified as Axinyssa sp., Plocamionida sp., Forcepia sp., Pachymatisma sp and Placospongia sp. The “non-polar” (EtOAc-MeOH) and “pola”r (EtOH-H2O) extracts of the marine sponges were prepared and subjected to 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, a total antioxidant ca...
1903
1014
IN-VITRO ANTIDIABETIC AND ANTIOXIDANT ACTIVITIES OF AQUEOUS AND ETHANOLIC EXTRACT OF VITIS VINIFERA SEEDS
In the present study, the aqueous and ethanolic extracts of Vitis vinifera seeds were studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The plant extracts were also examined for their antioxidant activities by using the free radical 1, 1-diphenyl-2-picryl hydrozyl (DPPH) scavenging method under in-vitro. The study revealed that the different concentrations of the ...
1902
992
MORPHOMETRY OF HUMAN SCAPULA GLENOID FOSSA AND ITS SURGICAL ANATOMY: AN OBSERVATIONAL STUDY IN EASTERN ODISHA
Introduction: Scapulae bear a shallow articular concave fossa commonly known as glenoid cavity that accommodates the head of the humerus to form a shoulder joint. The size and shape of glenoid fossa is highly variable; hence, knowledge about morphological measurements is invariably essential for surgery and artificial prosthesis pertaining to shoulder joint pathology. Aim: Glenoid fossa morphome...
1902
1044
FORMULATION DEVELOPMENT AND EVALUATION OF POLY AMIDOAMINE (PAMAM) DENDRIMERS AS POTENTIAL CARRIERS FOR ENHANCED TRANSDERMAL DELIVERY OF ITRACONAZOLE GEL FORMULATION
The drug of dendrigel, uses dendrimers as medicine carriers. Dendrimers were prepared by divergent growth techniques and were loaded in varying quantities in carbapol 934. To this mixture, itraconazole drug was added and the expression of dendrigel was estimated. Dendrimers were prepared by divergent growth techniques. Estimation parameters like color test, UV spectroscopy, and FTIR. Evaluation pa...
1901
1146
SOLUBILITY ENHANCEMENT OF LABETALOL HYDROCHLORIDE BY USING LIQUISOLID TECHNIQUE FOR MANAGEMENT OF HYPERTENSION
Background: Hypertension is the most common disorder affecting different age groups of people. The increased blood pressure creates discomfort in the patients; these cardiovascular diseases are risky which can lead to “mortality and morbidity”. Labetalol hydrochloride is an anti-hypertensive drug used to treat high blood pressure and Angina. These compounds possess less water solubility and lo...
1899
854
MICROWAVE ASSISTED SYNTHESIS AND EVALUATION OF ANTICONVULSANT ACTIVITY OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES
In the view of an extensive literature survey that revealed the anticonvulsant profile of 1,4-dihydropyridines and 1,3,4-Thiadiazole, we have coupled these two moieties with the aim of achieving an enhanced anticonvulsant effect. In present investigation some of ethyl-1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-5-ethyl-2, 6-dimethyl-4-substituted phenyl-1, 4-dihydro-pyridine-3-carboxylate derivat...
1899
1151