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IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....
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EFFECT OF DICHLOROMETHANE EXTRACT OF ALSTONIA SCHOLARIS LEAVES IN DIFFERENT MODELS OF DIABETIC NEPHROPATHY IN RATS
Aim: The main of the study is to study the Effect of Various Polar & Non-Polar Extracts of Alstonia scholaris leaves in Different Models of Diabetic Nephropathy in Rats. Material & Methods: Leaves of selected plant was extracted by using various solvents, i.e., Pet ether, Dichloromethane, Ethyl acetate, methanol and water. All the extracts were screened for the presence of various active p...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-UFLC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND METFORMIN HCl
A Simple, sensitive, precise, and stability-indicating method was developed for the simultaneous estimation of Telmisartan & Metformin HCl in bulk & prepared formulation. The column used for the separation was Phenomenex C18 (150 × 4.6, 5 µ), with a mobile phase containing Phosphate buffer pH 3.6 & acetonitrile (30:70% v/v) at a flow rate of 0.5 ml/min. The retention time of Telmisar...
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DESIGN SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES AS A NEW CLASS OF ANTI-CONVULSANT AGENTS
A novel series 3(a–d) 1-(4-benzhydryl piperazin-1-yl)-3-(di substituted) propan-1-one &1-(4-benzhydrylpiperazin-1-yl)-3-(piperidin-1-yl) propan-1-one (3e) & 1-(4-benzhydrylpiperazin-1-yl)-3-morpholinopropan-1-one (3f) compounds have been synthesized and screened for its anticonvulsant and neurotoxic activity, After i.p. injection to rat at doses of 30, 100, and 300 mg/kg body weight. Syn...
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HETEROCYCLE-FUSED BENZIMIDAZOLE: A PRIVILEGED SCAFFOLD IN ANTIMICROBIAL DRUG DISCOVERY
Compounds with heterocyclic moiety are important for life and are abundant in nature. Heterocyclic compounds have a crucial part in the metabolism of all biological cells. Humanity relies heavily on nitrogen-based heterocyclic compounds. Benzimidazole, in particular, is a vital component of the entire nitrogen-based heterocyclic chemical family, not just physiologically but also industrially. Beca...
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AN OUTLINE OF QUALITY GUIDELINES FOR DEVELOPING AND VALIDATING ANALYTICAL PROCEDURES
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while co...
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ASSESSING THE ANTIOXIDANT ACTIVITIES OF METHANOLIC EXTRACT OF SARACA ASOCA LEAVES AND BARK
Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf...
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SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES
1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral metho...
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HAEMATOLOGICAL RESPONSES OF CLARIAS BATRACHUS (LINN.) TO SUBLETHAL CONCENTRATIONS OF LEAD
Blood parameters (Hb%, TLC, TLC, ESR, PCV, MCV and MCH) of the catfish, Clarias batrachus (Linn.) were investigated, exposed to different concentrations of lead [Group- A (control), (Group- B (0.5ppm), Group- C (1.0ppm) and Group- D (3.0 ppm)] during different time intervals (7, 14, 21 and 28 days). Haemoglobin values fell to the maximum (11.5%) from its control value (13.0%). TEC values were al...
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MALE INFERTILITY: A REVIEW ON SPERMATOZOA PROTEOMICS AND FERTILITY-ASSOCIATED BIOMARKERS IDENTIFICATION
Male infertility has remained a complex multi-factorial disease and needs advanced molecular studies. The development of effective diagnostic capabilities has resulted in the desire to create minimally invasive tests to help in the understanding of the etiology of male infertility. In recent times, research on human sperm proteomics has gained momentum and provides detailed information regarding s...
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