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FREE RADICAL SCAVENGING POWER POTENTIATES ANALGESIC, ANTI-INFLAMMATORY AND CNS DEPRESSANT ACTIVITY OF ALANGIUM SALVIIFOLIUM WANG
Alangium salviifolium wang. Family Alangiaceae used as a traditional medicinal plant. The objective of this study was to evaluate the comparative phytochemical and in-vitro antioxidant activity along with analgesic, anti-inflammatory, and central nervous system (CNS) depressant activities of peel and seed extract of Alangium salviifolium fruit. Quantitative phytochemical analysis for total phenoli...
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HETEROCYCLE-FUSED BENZIMIDAZOLE: A PRIVILEGED SCAFFOLD IN ANTIMICROBIAL DRUG DISCOVERY
Compounds with heterocyclic moiety are important for life and are abundant in nature. Heterocyclic compounds have a crucial part in the metabolism of all biological cells. Humanity relies heavily on nitrogen-based heterocyclic compounds. Benzimidazole, in particular, is a vital component of the entire nitrogen-based heterocyclic chemical family, not just physiologically but also industrially. Beca...
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IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....
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MALE INFERTILITY: A REVIEW ON SPERMATOZOA PROTEOMICS AND FERTILITY-ASSOCIATED BIOMARKERS IDENTIFICATION
Male infertility has remained a complex multi-factorial disease and needs advanced molecular studies. The development of effective diagnostic capabilities has resulted in the desire to create minimally invasive tests to help in the understanding of the etiology of male infertility. In recent times, research on human sperm proteomics has gained momentum and provides detailed information regarding s...
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DESIGN SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES AS A NEW CLASS OF ANTI-CONVULSANT AGENTS
A novel series 3(a–d) 1-(4-benzhydryl piperazin-1-yl)-3-(di substituted) propan-1-one &1-(4-benzhydrylpiperazin-1-yl)-3-(piperidin-1-yl) propan-1-one (3e) & 1-(4-benzhydrylpiperazin-1-yl)-3-morpholinopropan-1-one (3f) compounds have been synthesized and screened for its anticonvulsant and neurotoxic activity, After i.p. injection to rat at doses of 30, 100, and 300 mg/kg body weight. Syn...
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IDENTIFICATION AND ISOLATION OF BIOACTIVE COMPONENTS USING GC-MS, UV VISIBLE, FTIR, HPLC, HPTLC AND ANTIOXIDANT ACTIVITY PRESENT IN ETHANOLIC EXTRACT OF INDIAN SPICES MIXTURE
Introduction: The spices, despite their taste and flavor, have certain therapeutical uses from ancient days. For this research work, we have chosen some selected spices indefinitely amount. Materials and Methods: Phytochemical analysis, mineral estimation Characterisations such as GC-MS, UV Visible & FTIR spectroscopy, HPLC, HPTLC, and Antioxidant activity were carried out. Results & Discu...
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AN OUTLINE OF QUALITY GUIDELINES FOR DEVELOPING AND VALIDATING ANALYTICAL PROCEDURES
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while co...
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SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES
1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral metho...
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HAEMATOLOGICAL RESPONSES OF CLARIAS BATRACHUS (LINN.) TO SUBLETHAL CONCENTRATIONS OF LEAD
Blood parameters (Hb%, TLC, TLC, ESR, PCV, MCV and MCH) of the catfish, Clarias batrachus (Linn.) were investigated, exposed to different concentrations of lead [Group- A (control), (Group- B (0.5ppm), Group- C (1.0ppm) and Group- D (3.0 ppm)] during different time intervals (7, 14, 21 and 28 days). Haemoglobin values fell to the maximum (11.5%) from its control value (13.0%). TEC values were al...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF RUTHENIUM (II) COMPLEXES OF SUBSTITUTED 2-{4, 5-BIS[(E)-2-PHENYLETHENYL]-1H-IMIDAZOL-2-YL}-1H-BENZIMIDAZOLE
Ruthenium(II) complexes of the type [Ru(bpy) 2(L)](PF6)2, where L= 2-{4,5-bis[(E)-2-phenylethenyl]-1H-imidazol-2-yl}-1H-benzimidazole (1), 2-{4,5-bis[(E)-2-(4-chlorophenyl)ethenyl]-1H-imidazol-2-yl}-1H-benzimi-dazole (2), 2-{4,5-bis [(E)-2-(4-fluorophenyl) ethenyl]-1H-imidazol-2-yl} -1H-benzimidazole (3), 2-{4 ,5-bis[(E)-2- (4-methylphenyl) ethenyl] -1H-imidazol-2-yl }-1H-benzimidazole (4), 2-{4, ...
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