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MALE INFERTILITY: A REVIEW ON SPERMATOZOA PROTEOMICS AND FERTILITY-ASSOCIATED BIOMARKERS IDENTIFICATION
Male infertility has remained a complex multi-factorial disease and needs advanced molecular studies. The development of effective diagnostic capabilities has resulted in the desire to create minimally invasive tests to help in the understanding of the etiology of male infertility. In recent times, research on human sperm proteomics has gained momentum and provides detailed information regarding s...
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DESIGN SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES AS A NEW CLASS OF ANTI-CONVULSANT AGENTS
A novel series 3(a–d) 1-(4-benzhydryl piperazin-1-yl)-3-(di substituted) propan-1-one &1-(4-benzhydrylpiperazin-1-yl)-3-(piperidin-1-yl) propan-1-one (3e) & 1-(4-benzhydrylpiperazin-1-yl)-3-morpholinopropan-1-one (3f) compounds have been synthesized and screened for its anticonvulsant and neurotoxic activity, After i.p. injection to rat at doses of 30, 100, and 300 mg/kg body weight. Syn...
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FREE RADICAL SCAVENGING POWER POTENTIATES ANALGESIC, ANTI-INFLAMMATORY AND CNS DEPRESSANT ACTIVITY OF ALANGIUM SALVIIFOLIUM WANG
Alangium salviifolium wang. Family Alangiaceae used as a traditional medicinal plant. The objective of this study was to evaluate the comparative phytochemical and in-vitro antioxidant activity along with analgesic, anti-inflammatory, and central nervous system (CNS) depressant activities of peel and seed extract of Alangium salviifolium fruit. Quantitative phytochemical analysis for total phenoli...
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EFFECT OF DICHLOROMETHANE EXTRACT OF ALSTONIA SCHOLARIS LEAVES IN DIFFERENT MODELS OF DIABETIC NEPHROPATHY IN RATS
Aim: The main of the study is to study the Effect of Various Polar & Non-Polar Extracts of Alstonia scholaris leaves in Different Models of Diabetic Nephropathy in Rats. Material & Methods: Leaves of selected plant was extracted by using various solvents, i.e., Pet ether, Dichloromethane, Ethyl acetate, methanol and water. All the extracts were screened for the presence of various active p...
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SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES
1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral metho...
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INSIGHTS INTO THE ROLES OF ANTIOXIDANTS IN CITRUS FRUITS
Citrus fruits are known for their nutritiousness. Role of vitamins and minerals play a major role in citrus fruits during plant-pathogen interactions. These fruits are the supreme fruit crops which contain flavonoids and phenolic compounds. These molecules benefit individuals who are all consuming and play an important role in fruit ripening and development. Mainly these molecules act as antioxida...
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AN OUTLINE OF QUALITY GUIDELINES FOR DEVELOPING AND VALIDATING ANALYTICAL PROCEDURES
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while co...
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IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....
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SEASONAL FLUCTUATIONS IN ARBUSCULAR MYCORRHIZAL FUNGAL COMMUNITIES: A REVIEW
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heav...
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BRIEF OVERVIEW STUDIES ON ENDOCRINE DISRUPTORS POLYCYCLIC AROMATIC HYDROCARBONS WITH SPECIAL REFERENCE TO NEWSPAPER INK
Now a day’s food materials are packaged and wrapped in paper that is the dangerous practice of wrapping, covering or processing foods with newspaper and printed recycled paper materials remains commonplace worldwide, as seen in the plethora of photographs in advertisements online or in magazines showing newspaper wrapped foods. The health hazard of ink contamination to foods and long-term contac...
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