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NOVEL INDOLE DERIVATIVES AS A PROMISING SCAFFOLD FOR THE DISCOVERY AND DEVELOPMENT OF POTENTIAL BIOLOGICAL ACTIVITIES: AN OVERVIEW
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple r...
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THE CHALLENGING ISSUES, DIAGNOSIS AND TREATMENT OF MUCORMYCOSIS-A NARRATIVE REVIEW
Mucormycosis is a new fungal disease that increased the morbidity and mortality rate in this present scenario. It's difficult to diagnose and cure due to proper scientific evidence is not yet being designed. The disease's prevalence appears to be rising. In high-income nations, hematological malignancies are the most prevalent underlying illness, while uncontrolled diabetes is usually linked to pu...
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CHRONOPHARMACOLOGICAL ASPECT ON IMPAIRMENT OF LIVER CIRCADIAN CLOCK AND HEPATIC DYSFUNCTION: A REVIEW
Hepatitis B, Diabetes, Alcoholic and Non-alcoholic Fatty Liver Disease, Cholangiocarcinoma, Cholangioleiomyopathies, and other risk factors for hepatic illness are all becoming more harmful nowadays. In animals, the dysfunction of melatonin levels and an unbalanced circadian rhythm can control physiological processes and cellular mechanisms during periods of rest and activity. The Suprachiasmatic ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER COUMARIN DERIVATIVES AS ANTIMICROBIAL AGENTS
For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity o...
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MEDICATION REGIMEN COMPLEXITY ASSESSMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ITS IMPACT ON MEDICATION ADHERENCE AND GLYCEMIC CONTROL: A CROSS-SECTIONAL STUDY IN TERTIARY CARE HOSPITAL, SOUTH KERALA
Background and Aim: The prevalence of DM worldwide is estimated to be 415 million, which is anticipated to surpass 642 million in the next 25 years. Good glycaemic control reduces the incidence of complications associated with diabetes and thus improves microvascular diseases. Complexity can be regarded as the root cause of low adherence and thus result in interactions. This study aimed to evaluat...
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HERBAL DRUG LOADED NANOGEL FOR EFFECTIVE TREATMENT OF SKIN DISORDERS
Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient's compatibility to deliver in various diseases,...
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SECONDARY METABOLITES, IN-VITRO ANTIOXIDANT AND ANTIULCER POTENTIAL OF THE PHYLLOCLADE EXTRACT OF MUEHLENBECKIA PLATYCLADA (F. MUELL) MEISN
The present study aimed to determine secondary metabolites, in-vitro antioxidant, and antiulcer activities using various solvent-based Muehlenbeckia platyclada extracts. Solvents based phylloclade extraction was used to determine various secondary metabolites such as phenols, flavonoids, terpenoids and tannins and to assess in-vitro antioxidant activities such as DPPH, ABTS.+, superoxide, hydrogen...
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ANTI-TUMOR ACTIVITY OF TARAXACUM OFFICINALE LAM. LEAVES AGAINST DMBA-INDUCED SKIN CANCER IN SWISS ALBINO MICE
Objective: To investigate the antitumor activity of different extracts (petroleum ether, ethanolic and aqueous extracts) of Taraxacum officinale against DMBA-induced skin cancer in mice. Methods: T. officinale leaves were successively extracted using petroleum ether (PTO), ethanol (ETO) and water (ATO). The antitumor activity was evaluated against DMBA-induced skin cancer in swiss albino mice. The...
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EVALUATION OF BINDING AFFINITY OF THE SELECTED HERBAL BIO-ACTIVE COMPONENTS WITH THE ENZYME CYP- 17Α-HYDROXYLASE BY PCOS AMELIORATION ACTIVITY THROUGH MOLECULAR DOCKING IN- SILICO APPROACH
Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeut...
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THERAPEUTIC RELEVANCE OF AEGLE MARMELOS: A REVIEW
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-trop...
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