Most Popular
EVALUATION OF POLYGONUM GLABRUM WILLD. LEAF EXTRACTS FOR ANTIOXIDANT PROPERTY
Polygonum glabrum, commonly called dense flower knotweed, is a perennial plant found in most parts of India. The leaves of plants Polygonum glabrum Willd. Belonging to the family, Polygonaceae are a rich source of flavonoids and tannins but not yet scientifically investigated for antioxidant activity. The present study aimed to offer a novel scientific background to the leaves of Polygonum glabrum...
1872
1048
MICROSPHERES: A NOVEL APPROACH FOR DELIVERY OF ANTIHYPERLIPIDEMIC DRUGS
Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the...
1871
1190
POTENTIAL NATURAL SKIN CANCER (MELANOMA) TREATMENTS USING FLAVONOIDS: BIOTHERAPEUTIC APPROACHES
There are a variety of treatment options for melanoma, but the high resistance of tumor cells to conventional therapies makes it necessary to develop new anticancer agents that will have decline toxic effects and greater effectiveness, thereby providing an incentive for the development of new treatments that can be used alone or in combination with other drugs. The flavonoids are phenolic phytocon...
1871
1037
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF VIBEGRON IN PURE AND PHARMACEUTICAL DOSAGE FORM
An accurate, sensitive, precise, fast isocratic reverse phase HPLC technique has been developed and validated for the quantification of Vibegron in the pure and pharmaceutical dosage form. The best separation was achieved on a 250 mm x 4.6 mm ID., 5µ-particle size Inertsil®-Octadecyl-Silyl-3V-Reverse-Phase-C18-column with 0.05M Ammonium dihydrogen orthophosphate in water: acetonitrile (60:40...
1871
1360
AN INTERPRETATION OF CARDIOVASCULAR COMPLICATIONS IN COVID-19 PATIENTS AND POST-COVID-19-VACCINATION, A PERUSAL
COVID-19, caused by Severe Acute Respiratory Syndrome CoV-2 (SARS CoV-2), has become a global burden. The naïve era of infection prompted early dependence on case reports of insufficient data and conceptual elucidation to explain and anticipate the effect on cardiovascular diseases. Many COVID-19-infected and vaccinated individuals have reported an increased incidence of cardiovascular disorders,...
1870
914
PHARMACOPHORE BASED MODELLING OF PYRIDINE-PYRIMIDINE ANALOGS AS MER TYROSINE KINASES INHIBITORS IN ANTICANCER THERAPY
MER kinase is an important tyrosine-kinase receptor that is associated with a variety of cancers, including mantle cell lymphomas, pituitary adenomas and T-cell acute lymphoblastic leukemia. Identification of new MERTK inhibitors assumes crucial importance. Only one ligand-based pharmacophore model is reported to date for MERTK inhibitors. There are many more molecules with improved enzyme inhibit...
1869
1049
EFFECT OF DIFFERENT ABIOTIC STRESSES ON ACETYLCHOLINESTERASE INHIBITION, ANTIOXIDANT ACTIVITY TOTAL PHENOL & FLAVONOID CONTENT OF SELECTED ALLIUM SPECIES: RESULTS FROM A 6-MONTH FIELD STUDY
Environmental factors influence plant growth, morphology, as well as nature and quantity of secondary metabolites. Modification of abiotic factors during plant growth can impact the production of bioactive phytoconstituents. A six-month field study was carried out to assess the effect of different abiotic stresses on bioactive compounds (flavonoids, phenols, quercetin), acetylcholine sterase (AChE...
1869
901
DIVALENT METAL COMPLEX OF COUMARIN: SYNTHESIS & CYTOTOXIC EVALUATION
Introduction: Coumarins are secondary metabolites widely spread in nature. Due to their broad pharmacological activities, many natural and synthetic coumarins and more complex related derivatives are of interest. The coumarin is extremely variable in structure due to the various types of substitutions in their basic structure, influencing their biological activity. Metal complexes of coumarins obt...
1869
1469
ANATOMICAL STUDIES OF ELAEOCARPUS SERRATUS LINN.
The medicinal plant Elaeocarpus serratus Linn., (Elaeocarpaceae) has been utilized in traditional medicine for various ailments. However, upon reviewing the literature, it was found that no anatomical work had been conducted on this plant. Therefore, our present study aimed to determine the macroscopic and microscopic characteristics of fresh leaf and stem of Elaeocarpus serratus. The macroscopic ...
1869
1138
A REVIEW ON PLANT OPILIA CELTIDIFOLIA: AN ASSESSMENT OF ITS BOTANY, CONVENTIONAL UTILIZATION, PHYTOCHEMISTRY AND PHARMACOLOGY
The plant Opilia celtidifolia, often known as ironwood or Opilia, is indigenous to many parts of Africa. It has a long history of traditional use in African herbal medicine, and its purported therapeutic benefits have attracted interest. An overview of Opilia celtidifolia's cultivation, the portions used, and the identification of its chemical components are given in this abstract. The savannahs, ...
1868
835